Protein Alignment RPS6KA2 and YPK3

DIOPT Version :9

• Sequence 1: XP_006715612.1
• Gene: RPS6KA2 / 6196
• HGNCID: 10431
• Length: 761
• Species: Homo sapiens
• Sequence 2: NP_009584.1
• Gene: YPK3 / 852316
• SGDID: S000000232
• Length: 525
• Species: Saccharomyces cerevisiae
• Alignment Length: 463
• Identity: 151/463 - (32%)
• Similarity: 225/463 - (48%)
• Gaps: 86/463 - (18%)

Human    21 KSRSKSSSLSRLEGL----NRRAAGIKVVTIADCLHSREPETQHEEEGVVKEIDISHHVKEGFEK 81
            :.|.:||:.|:...|    .||.:    :|.:|.:     .|......:..:..||.::.|....
Yeast    67 RMRRRSSAYSKFPILTPPNTRRFS----ITGSDAM-----RTNTNRLSITPQDIISSNIGENELS 122

Human    82 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRV-------------- 132
            .:...|:.::|||||:||||.||:.|..|   :|||||.|:||.:.:....
Yeast   123 RNLHDFKPVRVLGQGAYGKVLLVKDVNTS---KLYAMKQLRKAEILISQTATDSKREDEDKNDGN 184

Human   133 -------------RSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 184
                         |:..||.||:|:.||.||||.|:|....||||:|.::.||:||..|.:....
Yeast   185 NNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGTL 249

Human   185 TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE-----AIDHD--- 241
            .|..|.||.||::.||..||:.|::||||||||.||::.||:.:|||||||:     |:|.:
Yeast   250 DETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAVDEEDPE 314

Human   242 --KRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL 304
              ...||..||.||.|||::..:.::|:.||:|.|.|:::||.|..|:.|.:.|..:..|.:.|.
Yeast   315 NVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNHKVIINKIQQNKQ 379

Human   305 G--MPQFLSGEAQSLLRALFKRNPCNR---------LGAGIDGVEEIKR------------HPFF 346
            |  :|.:||...:.:|.||.|:....|         .||.....:..|:            |..|
Yeast   380 GPKIPFYLSEGMKDILNALLKKETAKRWNVDKYWAKTGANNKPTKSKKKKSGAARTSLFTEHFIF 444

Human   347 VTIDWNTL----YRKEIKPPFKPAVGRPEDTFHFDPEFTA----RTPTDSP--GVPPSANAHHLF 401
            ..|||..|    .:|....|..|.:...|...:||.|||:    .|.|||.  .:...:.:..:|
Yeast   445 RKIDWKLLESGQLQKTTLGPIVPVITDLELAENFDTEFTSMSYEETYTDSKPININSVSKSPDMF 509

Human   402 RGFSFVAS 409
            :|||:.||
Yeast   510 KGFSYKAS 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	114/318 (36%)
		STKc_RSK_N	91..407	CDD:270734	135/385 (35%)
		STKc_RSK3_C	439..731	CDD:271080
		Pkinase	443..700	CDD:278497
YPK3	NP_009584.1	STKc_AGC	134..406	CDD:270693	107/274 (39%)
		S_TK_X	445..516	CDD:214529	21/70 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159045411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870