DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA2 and rps6ka2

DIOPT Version :9

Sequence 1:	XP_006715612.1	Gene:	RPS6KA2 / 6196	HGNCID:	10431	Length:	761	Species:	Homo sapiens
Sequence 2:	XP_699952.2	Gene:	rps6ka2 / 571285	ZFINID:	ZDB-GENE-090827-1	Length:	733	Species:	Danio rerio

Alignment Length:	761	Identity:	653/761 - (85%)
Similarity:	693/761 - (91%)	Gaps:	28/761 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEGLNRRAAGIKVVTIADCLHSREPETQHEEEGV 65
            ||.:|:||.|||:||||||||||||||||.:|                            |::.:
Zfish     1 MDTNMRKFTVRRWFSVYLRRKSRSKSSSLCKL----------------------------EDDSI 37

Human    66 VKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRD 130
            :||.|||||||||||||||||||||||||||||||||||||:||||.||||||||||||||||||
Zfish    38 LKEFDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKIKGSDTGQLYAMKVLKKATLKVRD 102

Human   131 RVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   103 RVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 167

Human   196 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   168 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 232

Human   261 RRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRN 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||.|.|||||||||||
Zfish   233 RRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSPEVQSLLRALFKRN 297

Human   326 PCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPG 390
            |.||||||.|||||||||.||.|||||.|||:||||||||||||||||||||||||:||||||||
Zfish   298 PSNRLGAGPDGVEEIKRHIFFATIDWNKLYRREIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSPG 362

Human   391 VPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYS 455
            ||.|||||.|||||||||::|.||....::.:..|:||||||||||||||||||:|||||:|:||
Zfish   363 VPASANAHQLFRGFSFVATNLGQEQPLTEIKQNSVNPIVQQLHGNNIHFTDGYELKEDIGIGAYS 427

Human   456 VCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 520
            |||||||:.|..||||||||:||:|||||||||||||||||||||||||||||||||||||||||
Zfish   428 VCKRCVHRITSVEYAVKIIDRSKKDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 492

Human   521 ELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGF 585
            |||||||||:.|||||||.||||||||::|||||||||||||||||||.||:|.|||||:|||||
Zfish   493 ELLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYVDETGDPESIRICDFGF 557

Human   586 AKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 650
            ||||||.||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish   558 AKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 622

Human   651 LARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQD 715
            ||||||||:||||||||::||||||:|:|||||||||||||..||:|.|:|||:.||.:||.|||
Zfish   623 LARIGSGKFALSGGNWDTVSDAAKDIVTKMLHVDPHQRLTAPLVLRHAWIVNRDQLSQSQLIRQD 687

Human   716 VHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 761
            |.||||||||||.||||:||||:|||||||.|||||||||||||||
Zfish   688 VTLVKGAMAATYSALNRSPQAPKLEPVLSSCLAQRRGMKRLTSTRL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	251/258 (97%)
		STKc_RSK_N	91..407	CDD:270734	302/315 (96%)
		STKc_RSK3_C	439..731	CDD:271080	254/291 (87%)
		Pkinase	443..700	CDD:278497	227/256 (89%)
rps6ka2	XP_699952.2	S_TKc	59..318	CDD:214567	251/258 (97%)
		STKc_RSK_N	63..379	CDD:270734	302/315 (96%)
		PKc_like	411..703	CDD:304357	254/291 (87%)
		Pkinase	415..672	CDD:278497	227/256 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324880
Domainoid	1	1.000	503	1.000	Domainoid score	I2715
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100680
Inparanoid	1	1.050	1324	1.000	Inparanoid score	I1300
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		oto49492
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.200