DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA2 and JIL-1

DIOPT Version :9

Sequence 1:	XP_006715612.1	Gene:	RPS6KA2 / 6196	HGNCID:	10431	Length:	761	Species:	Homo sapiens
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	259/731 - (35%)
Similarity:	365/731 - (49%)	Gaps:	80/731 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    26 SSSLSRLEGLNRRAAGIKVVTIADCLHSREPET----------------------QHEEEGVVKE 68
            |||||:.:..|..||.......|....|:...:                      |.:.|.|.
  Fly   180 SSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEAVT-- 242

Human    69 IDISHHVK-EGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRD 130
             |:.::|| ...|....:.|::::|||.|:||:||||||:...|||:|||||||.|.|:  |.:.
  Fly   243 -DLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKT 306

Human   131 RVRSKMERDILAEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 194
            ...:|.||.:|..: .:||:|.||||||:..||||:|||..||:|||.|.....|.|..|:.|:|
  Fly   307 AEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIA 371

Human   195 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK-EAIDHDKRAYSFCGTIEYMAPEV 258
            |:.|||:.||.|||||||:|.||||||.||||.::|||||| ...:::.||:|||||:||||||:
  Fly   372 EVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEI 436

Human   259 VNR--RGHTQSADWWSFGVLMFEMLTGSLPFQGKD----RKETMALILKAKLGMPQFLSGEAQSL 317
            :..  .||..:.||||.|||.||:|||:.||...|    :.|....|.|.:..:|...|..|:..
  Fly   437 IRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDF 501

Human   318 LRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTA 382
            :..:.::||..|||.......|||.||||..|:|..|..|..|.|:||.:...:|..:|..|||.
  Fly   502 VLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTD 566

Human   383 RTPTDSP-GVPPSANAHHLFRGFSFVASSLIQEPSQQD----------LHKVPVHPIVQQLHGNN 436
            :.|.|.. ..|||  ...||||:::||...:::..:.:          |..:|..|
  Fly   567 QVPEDPECDAPPS--RIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCRP--------- 620

Human   437 IHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEE---IEILLRYGQHPNII 498
                |..|:......|:|..|...|..:||..:..|||..||..|||.   |...|....|.||:
  Fly   621 ----DDLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIV 681

Human   499 TLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKP 563
            :....:.:....::|||.:.|.||...|    ...|....::...:...:.::||:..:|.||||
  Fly   682 SYHGTFREKCETWIVMEYLSGPELTASI----RMDEDSCREIFLQLVMAVRHIHSKHFIHGDLKP 742

Human   564 SNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG---YDAACDIWSL 625
            .||::  |:....::::.|||.|............|.||.::..||:|....   |..|.||:.|
  Fly   743 ENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGL 805

Human   626 GILLYTMLAGFTPFANGPDDTP------EEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVD 684
            |..|||||.|..|:....||..      .|:..|:..|.:......|:|.|.|.:.:||..|..|
  Fly   806 GATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRD 870

Human   685 PHQRLTAMQVLKHPWV 700
            |..|.|...:|...|:
  Fly   871 PADRPTLSDILDSEWL 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	133/268 (50%)
		STKc_RSK_N	91..407	CDD:270734	156/326 (48%)
		STKc_RSK3_C	439..731	CDD:271080	80/274 (29%)
		Pkinase	443..700	CDD:278497	78/268 (29%)
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	133/268 (50%)
		STKc_MSK_N	266..533	CDD:270735	134/266 (50%)
		S_TK_X	532..591	CDD:214529	22/60 (37%)
		S_TKc	632..886	CDD:214567	77/259 (30%)
		PKc_like	632..885	CDD:304357	77/258 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750