DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA2 and psk1

DIOPT Version :9

Sequence 1:	XP_006715612.1	Gene:	RPS6KA2 / 6196	HGNCID:	10431	Length:	761	Species:	Homo sapiens
Sequence 2:	NP_587830.1	Gene:	psk1 / 2539494	PomBaseID:	SPCC4G3.08	Length:	436	Species:	Schizosaccharomyces pombe

Alignment Length:	405	Identity:	168/405 - (41%)
Similarity:	235/405 - (58%)	Gaps:	42/405 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    33 EGLNRRAAGIKVVTIADCLHSREPETQHEEEGVVKEIDISHH-----------VKEGFEKADPSQ 86
            ||.:.........||......::.:...:|:|.| |..::.|           |..|  |..|:.
pombe    29 EGYDFEELEASASTITSSSDLKDGKNAKDEKGTV-EFKVAAHGDFISSKGDNYVPSG--KMRPAD 90

Human    87 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDR--VRSKMERDILAEVNHPFI 149
            |:.|.|||:||||||.|   ||..:.|:|:|.|.||||::.:|.:  .::|.||.||.||.||||
pombe    91 FQPLTVLGRGSYGKVLL---VKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVRHPFI 152

Human   150 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLK 214
            .:|:||||...:|||||.:..||:||:.|:::.|..|:.|.||.|||.|||.|||.|||:|||||
pombe   153 CRLYYAFQDHDRLYLILQYAPGGELFSHLAEQRMLPEDVVAFYTAELTLALIHLHKLGIVYRDLK 217

Human   215 PENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFE 279
            |||.|||.||||.:|||||||.| ::.....||.||.||.|||::..:.:..:.||||.|:|:|:
pombe   218 PENCLLDAEGHILLTDFGLSKVA-ENGADCRSFVGTEEYCAPEILLEQPYDHAVDWWSMGILIFD 281

Human   280 MLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEE----I 340
            :||||.||...:.|..|..|.:||..:|.:::.:|:.::....|:||..||||  ||.|:    |
pombe   282 LLTGSPPFTANNHKRIMEKITRAKPNIPFYVTSDARDIINKFLKKNPKQRLGA--DGPEKGYDAI 344

Human   341 KRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP-----------GVPPS 394
            |:|..:..||||.|.::.:.||..|.:..||...:|..|||....:.:|           |...|
pombe   345 KKHRIYRRIDWNKLEKRMLPPPIVPCITNPEAAENFSVEFTKLPLSTTPILHEEFGNLTIGSHSS 409

Human   395 ANAHHLFRGFSFVAS 409
            |     |:||::|||
pombe   410 A-----FQGFTYVAS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	131/264 (50%)
		STKc_RSK_N	91..407	CDD:270734	150/332 (45%)
		STKc_RSK3_C	439..731	CDD:271080
		Pkinase	443..700	CDD:278497
psk1	NP_587830.1	S_TKc	91..335	CDD:214567	125/249 (50%)
		STKc_AGC	97..350	CDD:270693	128/258 (50%)
		S_TK_X	351..418	CDD:214529	21/71 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	271	1.000	Domainoid score	I381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53890
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940