Protein Alignment RPS6KA2 and rps6ka2

DIOPT Version :9

• Sequence 1: XP_006715612.1
• Gene: RPS6KA2 / 6196
• HGNCID: 10431
• Length: 761
• Species: Homo sapiens
• Sequence 2: XP_002942396.3
• Gene: rps6ka2 / 100495717
• XenbaseID: XB-GENE-487242
• Length: 732
• Species: Xenopus tropicalis
• Alignment Length: 762
• Identity: 640/762 - (83%)
• Similarity: 688/762 - (90%)
• Gaps: 31/762 - (4%)

Human     1 MDL-SMKKFAVRRFFSVYLRRKSRSKSSSLSRLEGLNRRAAGIKVVTIADCLHSREPETQHEEEG 64
            |:| :::||.|||||||||.:|||:|:||.:|                            :|:||
 Frog     1 MELNNVRKFTVRRFFSVYLHKKSRTKTSSFNR----------------------------YEDEG 37

Human    65 VVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVR 129
            :|||||||||||||||||:||||||||||||||||||||||||||||:.||||||||:|||||||
 Frog    38 IVKEIDISHHVKEGFEKAEPSQFELLKVLGQGSYGKVFLVRKVKGSDSEQLYAMKVLRKATLKVR 102

Human   130 DRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 194
            |||||:||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
 Frog   103 DRVRSRMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFSRLSKEVMFTEEDVKFYLA 167

Human   195 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 259
            |||||||||||.||||||||||||||||||||||||||||||:||||||||||||||||||||||
 Frog   168 ELALALDHLHSFGIIYRDLKPENILLDEEGHIKITDFGLSKESIDHDKRAYSFCGTIEYMAPEVV 232

Human   260 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKR 324
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||
 Frog   233 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSSEAQCLLRALFKR 297

Human   325 NPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP 389
            |||||||||:|||||||||.||.|||||.||||||||||||||||||||||||||||:|||||||
 Frog   298 NPCNRLGAGLDGVEEIKRHSFFSTIDWNNLYRKEIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSP 362

Human   390 GVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSY 454
            |:|||||.|:||||||:||.:|...|  .|.:...||||||||||:||.|:|||.||||:|:|:|
 Frog   363 GIPPSANTHNLFRGFSYVAPNLDYNP--HDSYNSSVHPIVQQLHGSNIQFSDGYMIKEDLGIGTY 425

Human   455 SVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRG 519
            ::|||||||||:||:|||||||||||||||||||||||||||||||||||||||:||||||||.|
 Frog   426 AICKRCVHKATNTEFAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMMG 490

Human   520 GELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFG 584
            |||||:||||:.|||||||.|||.||||.:|||:|||||||||||||||.||||:|||||:||||
 Frog   491 GELLDKILRQKCFSEREASAVLCVITKTAEYLHTQGVVHRDLKPSNILYMDESGNPESIRICDFG 555

Human   585 FAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 649
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||
 Frog   556 FAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPEDTPEE 620

Human   650 ILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQ 714
            ||||||||||||:|||||||||||||:|:|||||||||||||.|||.|||:|||||||.|||||.
 Frog   621 ILARIGSGKYALTGGNWDSISDAAKDIVAKMLHVDPHQRLTATQVLHHPWIVNREYLSQNQLSRH 685

Human   715 DVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 761
            |..|||.||.|||||||..|.||:||||.||.||:||||.|:|||||
 Frog   686 DYRLVKAAMEATYFALNHRPLAPKLEPVNSSTLAKRRGMNRVTSTRL 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	247/258 (96%)
		STKc_RSK_N	91..407	CDD:270734	298/315 (95%)
		STKc_RSK3_C	439..731	CDD:271080	255/291 (88%)
		Pkinase	443..700	CDD:278497	228/256 (89%)
rps6ka2	XP_002942396.3	STKc_RSK_N	64..380	CDD:270734	298/315 (95%)
		STKc_RSK3_C	410..702	CDD:271080	255/291 (88%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	502	1.000	Domainoid score	I3700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100680
Inparanoid	1	1.050	1305	1.000	Inparanoid score	I1904
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		oto159601
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.060