DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA1 and S6kII

DIOPT Version :9

Sequence 1:	NP_001006666.1	Gene:	RPS6KA1 / 6195	HGNCID:	10430	Length:	744	Species:	Homo sapiens
Sequence 2:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	431/751 - (57%)
Similarity:	531/751 - (70%)	Gaps:	62/751 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    39 SGPQRDSDEGVLK---EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLY 100
            |.|..:..|.:.:   |..:...:|.|.:|||||.||||:|||:|||||||||||:...|:|.||
  Fly   164 SAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLY 228

Human   101 AMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 165
            ||||||||||||:||||:..||.|||||.|.|:|:|||||||.||||||||||||||||||||||
  Fly   229 AMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKE 293

Human   166 VMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 230
            |||||||||||||||||.::|||:|||||||||||||||||.|||.||||||||:.:| ..|.||
  Fly   294 VMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYS 357

Human   231 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLS 295
            |||||||||||:|||:||..:|||||:||||:|||||:|||.|:.|:|||..||::|||||:.||
  Fly   358 FCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLS 422

Human   296 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360
            .||||||||||||||.||||:|..|..:||.|.|::||||.:|.|::::|||.|||:: ||.|||
  Fly   423 PEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYF 486

Human   361 DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLME----DDGKPRAPQAPLHSVVQ------- 414
            |.|:||::|:||||.|.||.||::||||||||..|:|    .........:||||:..
  Fly   487 DVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVG 551

Human   415 -------QLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---------SKR 463
                   .|.|.   |...|.:.:.:|.|::|.|:.|.|:|:...||||||:|         :..
  Fly   552 APRTLPGVLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSA 613

Human   464 DPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTI 528
            |..||:||:||||.||||:||..||:|....|||.||::||||||:||......|.|||.||.||
  Fly   614 DCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTI 678

Human   529 GKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 593
            ...|.|||..|||||||||||::|......||.|::||.||||||||:|||||||||||||||||
  Fly   679 ASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPE 743

Human   594 VLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 658
            ||||||||..|||||||:|||.||:|.||||:.|:|:|:.||.|||||:...:...|..:|..||
  Fly   744 VLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAK 808

Human   659 DLVSKMLHVDPHQRLTAKQVLQHPW----------VTQKDKLPQSQLS---------HQDLQLVK 704
            :|:.:|||:.|..|.||.::|:|.|          :|:....|.||||         |..:.| :
  Fly   809 ELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMAL-R 872

Human   705 GAMAATYSALNSSKPTPQ---LKPIESSILAQRRVR 737
            ||:.||:.|:    ..||   :.|:|.|:||:||.:
  Fly   873 GAVDATFRAI----AIPQAANVGPVELSMLAKRRAK 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA1	NP_001006666.1	S_TKc	71..329	CDD:214567	199/257 (77%)
		STKc_RSK_N	75..391	CDD:270734	232/315 (74%)
		STKc_RSK1_C	425..715	CDD:271077	163/317 (51%)
		Pkinase	427..684	CDD:278497	150/275 (55%)
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	199/258 (77%)
		STKc_RSK_N	203..517	CDD:270734	232/315 (74%)
		STKc_RSK_C	567..883	CDD:270993	163/320 (51%)
		S_TKc	568..834	CDD:214567	149/265 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I752
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	822	1.000	Inparanoid score	I470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm41769
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810