Protein Alignment RPS6KA1 and psk1

DIOPT Version :10

• Sequence 1: NP_001006666.1
• Gene: RPS6KA1 / 6195
• HGNCID: 10430
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_587830.1
• Gene: psk1 / 2539494
• PomBaseID: SPCC4G3.08
• Length: 436
• Species: Schizosaccharomyces pombe
• Alignment Length: 367
• Identity: 161/367 - (43%)
• Similarity: 227/367 - (61%)
• Gaps: 23/367 - (6%)

Human    46 DEGVLKEISITHHVKAGSEKAD---------PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYA 101
            ||....|..:..|....|.|.|         |:.|:.|.|||:||:|||.||:   :.::|.|:|
pombe    57 DEKGTVEFKVAAHGDFISSKGDNYVPSGKMRPADFQPLTVLGRGSYGKVLLVK---QKNTGRLFA 118

Human   102 MKVLKKATLKVRDR--VRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 164
            .|.||||::.:|.:  .:||.||.||.:|.|||:.:|:||||...:|||||.:..||:||:.|::
pombe   119 QKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRLYYAFQDHDRLYLILQYAPGGELFSHLAE 183

Human   165 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 229
            :.|..|:.|.||.|||.|.|.|||.|||:||||||||.|||.||||.||||||||.| ::.....
pombe   184 QRMLPEDVVAFYTAELTLALIHLHKLGIVYRDLKPENCLLDAEGHILLTDFGLSKVA-ENGADCR 247

Human   230 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFL 294
            ||.||.||.|||::..|.:.|:.||||.|:|:|::||||.||...:.|..|..|.:||..:|.::
pombe   248 SFVGTEEYCAPEILLEQPYDHAVDWWSMGILIFDLLTGSPPFTANNHKRIMEKITRAKPNIPFYV 312

Human   295 STEAQSLLRALFKRNPANRLGS-GPD-GAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 357
            :::|:.::....|:||..|||: ||: |.:.||:|..|..||||||.:|.:.||..|.:..|:..
pombe   313 TSDARDIINKFLKKNPKQRLGADGPEKGYDAIKKHRIYRRIDWNKLEKRMLPPPIVPCITNPEAA 377

Human   358 FYFDTEFTSRTPKDSPGIPP-----SAGAH-QLFRGFSFVAT 393
            ..|..|||......:|.:..     :.|:| ..|:||::||:
pombe   378 ENFSVEFTKLPLSTTPILHEEFGNLTIGSHSSAFQGFTYVAS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA1	NP_001006666.1	STKc_RSK_N	75..391	CDD:270734	149/325 (46%)
		STKc_RSK1_C	425..715	CDD:271077
psk1	NP_587830.1	STKc_AGC	97..350	CDD:270693	126/256 (49%)
		S_TK_X	351..418	CDD:214529	21/66 (32%)