DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA1 and psk1

DIOPT Version :9

Sequence 1:	NP_001006666.1	Gene:	RPS6KA1 / 6195	HGNCID:	10430	Length:	744	Species:	Homo sapiens
Sequence 2:	NP_587830.1	Gene:	psk1 / 2539494	PomBaseID:	SPCC4G3.08	Length:	436	Species:	Schizosaccharomyces pombe

Alignment Length:	367	Identity:	161/367 - (43%)
Similarity:	227/367 - (61%)	Gaps:	23/367 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    46 DEGVLKEISITHHVKAGSEKAD---------PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYA 101
            ||....|..:..|....|.|.|         |:.|:.|.|||:||:|||.||:   :.::|.|:|
pombe    57 DEKGTVEFKVAAHGDFISSKGDNYVPSGKMRPADFQPLTVLGRGSYGKVLLVK---QKNTGRLFA 118

Human   102 MKVLKKATLKVRDR--VRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 164
            .|.||||::.:|.:  .:||.||.||.:|.|||:.:|:||||...:|||||.:..||:||:.|::
pombe   119 QKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRLYYAFQDHDRLYLILQYAPGGELFSHLAE 183

Human   165 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 229
            :.|..|:.|.||.|||.|.|.|||.|||:||||||||.|||.||||.||||||||.| ::.....
pombe   184 QRMLPEDVVAFYTAELTLALIHLHKLGIVYRDLKPENCLLDAEGHILLTDFGLSKVA-ENGADCR 247

Human   230 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFL 294
            ||.||.||.|||::..|.:.|:.||||.|:|:|::||||.||...:.|..|..|.:||..:|.::
pombe   248 SFVGTEEYCAPEILLEQPYDHAVDWWSMGILIFDLLTGSPPFTANNHKRIMEKITRAKPNIPFYV 312

Human   295 STEAQSLLRALFKRNPANRLGS-GPD-GAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 357
            :::|:.::....|:||..|||: ||: |.:.||:|..|..||||||.:|.:.||..|.:..|:..
pombe   313 TSDARDIINKFLKKNPKQRLGADGPEKGYDAIKKHRIYRRIDWNKLEKRMLPPPIVPCITNPEAA 377

Human   358 FYFDTEFTSRTPKDSPGIPP-----SAGAH-QLFRGFSFVAT 393
            ..|..|||......:|.:..     :.|:| ..|:||::||:
pombe   378 ENFSVEFTKLPLSTTPILHEEFGNLTIGSHSSAFQGFTYVAS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA1	NP_001006666.1	S_TKc	71..329	CDD:214567	129/261 (49%)
		STKc_RSK_N	75..391	CDD:270734	149/325 (46%)
		STKc_RSK1_C	425..715	CDD:271077
		Pkinase	427..684	CDD:278497
psk1	NP_587830.1	S_TKc	91..335	CDD:214567	123/247 (50%)
		STKc_AGC	97..350	CDD:270693	126/256 (49%)
		S_TK_X	351..418	CDD:214529	21/66 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	271	1.000	Domainoid score	I381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53890
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940