Protein Alignment RPS6KA1 and rps6ka1

DIOPT Version :10

• Sequence 1: NP_001006666.1
• Gene: RPS6KA1 / 6195
• HGNCID: 10430
• Length: 744
• Species: Homo sapiens
• Sequence 2: XP_012811865.1
• Gene: rps6ka1 / 100144704
• XenbaseID: XB-GENE-479496
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 699
• Identity: 612/699 - (87%)
• Similarity: 652/699 - (93%)
• Gaps: 2/699 - (0%)

Human    46 DEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL 110
            ||.|:|||.||||||.||||||.|||.||||||||||||||||||:|.||:..||||||||||||
 Frog    54 DEVVVKEIPITHHVKEGSEKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATL 118

Human   111 KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 175
            ||||||||||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||
 Frog   119 KVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 183

Human   176 YLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 240
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   184 YLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 248

Human   241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRAL 305
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.|||:|
 Frog   249 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSL 313

Human   306 FKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPK 370
            |||||.||||||.:||||||||.|:|||||||||||::.|||||||.|||||:||||||||||||
 Frog   314 FKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPK 378

Human   371 DSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGV 435
            ||||||||||||||||||||||..|:|:|.| :....|:.| |.:.|.||::|:|.|.|:|||||
 Frog   379 DSPGIPPSAGAHQLFRGFSFVAPVLVEEDAK-KTSSPPVLS-VPKTHSKNVLFTDVYTVRETIGV 441

Human   436 GSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTEL 500
            ||||.|||||||.||||||||||||:|||||||||||.|||||||||||||||::|..:||||||
 Frog   442 GSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTEL 506

Human   501 MRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 565
            ||||||||:||||||||||||:.||.|:.|||||||||||||||||||||||||||||||.:|||
 Frog   507 MRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRIC 571

Human   566 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDT 630
            |||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||.||
 Frog   572 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDT 636

Human   631 PEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQL 695
            |||||.|||||||||.||||||||::||||||:|||||||:||||||||||.|:|.:|.||||||
 Frog   637 PEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQL 701

Human   696 SHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTTL 744
            :.||:.||||||||||||||||||||||:||:|||||||||:|||||||
 Frog   702 NRQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTTL 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA1	NP_001006666.1	STKc_RSK_N	75..391	CDD:270734	295/315 (94%)
		STKc_RSK1_C	425..715	CDD:271077	252/289 (87%)
rps6ka1	XP_012811865.1	STKc_RSK_N	83..399	CDD:270734	295/315 (94%)
		Protein Kinases, catalytic domain	431..721	CDD:473864	252/289 (87%)