DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA1 and rps6ka1

DIOPT Version :9

Sequence 1:	NP_001006666.1	Gene:	RPS6KA1 / 6195	HGNCID:	10430	Length:	744	Species:	Homo sapiens
Sequence 2:	XP_012811865.1	Gene:	rps6ka1 / 100144704	XenbaseID:	XB-GENE-479496	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	612/699 - (87%)
Similarity:	652/699 - (93%)	Gaps:	2/699 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    46 DEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL 110
            ||.|:|||.||||||.||||||.|||.||||||||||||||||||:|.||:..||||||||||||
Frog    54 DEVVVKEIPITHHVKEGSEKADQSHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATL 118

Human   111 KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 175
            ||||||||||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||
Frog   119 KVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 183

Human   176 YLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 240
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   184 YLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 248

Human   241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRAL 305
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.|||:|
Frog   249 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSNEAQGLLRSL 313

Human   306 FKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPK 370
            |||||.||||||.:||||||||.|:|||||||||||::.|||||||.|||||:||||||||||||
Frog   314 FKRNPTNRLGSGVEGAEEIKRHPFFSTIDWNKLYRRDMSPPFKPAVTQPDDTYYFDTEFTSRTPK 378

Human   371 DSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGV 435
            ||||||||||||||||||||||..|:|:|.| :....|:.| |.:.|.||::|:|.|.|:|||||
Frog   379 DSPGIPPSAGAHQLFRGFSFVAPVLVEEDAK-KTSSPPVLS-VPKTHSKNVLFTDVYTVRETIGV 441

Human   436 GSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTEL 500
            ||||.|||||||.||||||||||||:|||||||||||.|||||||||||||||::|..:||||||
Frog   442 GSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRRYGQHPNIITLKDVYEEGNSIYLVTEL 506

Human   501 MRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 565
            ||||||||:||||||||||||:.||.|:.|||||||||||||||||||||||||||||||.:|||
Frog   507 MRGGELLDRILRQKFFSEREANLVLLTVCKTVEYLHSQGVVHRDLKPSNILYVDESGNPESIRIC 571

Human   566 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDT 630
            |||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||.||
Frog   572 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILVYTMLAGYTPFANGPGDT 636

Human   631 PEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQL 695
            |||||.|||||||||.||||||||::||||||:|||||||:||||||||||.|:|.:|.||||||
Frog   637 PEEILARIGSGKFTLRGGNWNTVSDSAKDLVSRMLHVDPHRRLTAKQVLQHEWITNRDLLPQSQL 701

Human   696 SHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTTL 744
            :.||:.||||||||||||||||||||||:||:|||||||||:|||||||
Frog   702 NRQDVHLVKGAMAATYSALNSSKPTPQLQPIKSSILAQRRVKKLPSTTL 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA1	NP_001006666.1	S_TKc	71..329	CDD:214567	243/257 (95%)
		STKc_RSK_N	75..391	CDD:270734	295/315 (94%)
		STKc_RSK1_C	425..715	CDD:271077	252/289 (87%)
		Pkinase	427..684	CDD:278497	228/256 (89%)
rps6ka1	XP_012811865.1	S_TKc	79..338	CDD:214567	243/258 (94%)
		STKc_RSK_N	83..399	CDD:270734	295/315 (94%)
		PKc_like	431..721	CDD:304357	252/289 (87%)
		Pkinase	433..690	CDD:278497	228/256 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I3911
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55703
Inparanoid	1	1.050	1264	1.000	Inparanoid score	I2028
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		oto153523
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060