DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RPS6 and RpS6

DIOPT Version :9

Sequence 1:	NP_001001.2	Gene:	RPS6 / 6194	HGNCID:	10429	Length:	249	Species:	Homo sapiens
Sequence 2:	NP_511073.1	Gene:	RpS6 / 31700	FlyBaseID:	FBgn0261592	Length:	248	Species:	Drosophila melanogaster

Alignment Length:	250	Identity:	187/250 - (74%)
Similarity:	214/250 - (85%)	Gaps:	3/250 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQ 65
            ||||:|:||||||||.||.||.|||.||||||...|.||.||:|||||.:||:||||||||||||
  Fly     1 MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQLRIAGGNDKQGFPMKQ 65

Human    66 GVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVP 130
            ||||||||||||.|||||||||||||||||||||||||||:|||.||::||||||||||||||:|
  Fly    66 GVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDANMSVLALVVLKKGEKDIPGLTDTTIP 130

Human   131 RRLGPKRASRIRKLFNLSKEDDVRQYVVRKPL-NKEGKKPRTKAPKIQRLVTPRVLQHKRRRIAL 194
            |||||||||:||||:|||||||||::|||:|| .|:.||..:||||||||:||.|||.|.|||||
  Fly   131 RRLGPKRASKIRKLYNLSKEDDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIAL 195

Human   195 KKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK 249
            ||:|...:||.:|:|||||.:|.||:|.||:|  |||||.:|:|.|.|...|.:|
  Fly   196 KKKRQIASKEASADYAKLLVQRKKESKAKREE--AKRRRSASIRESKSSVSSDKK 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6	NP_001001.2	Ribosomal_S6e	1..215	CDD:412654	169/214 (79%)
RPS6	NP_001001.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..249		16/31 (52%)
RpS6	NP_511073.1	Ribosomal_S6e	1..222	CDD:294602	172/220 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142963
Domainoid	1	1.000	222	1.000	Domainoid score	I2591
eggNOG	1	0.900	-	-		E1_COG2125
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H85949
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2149
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53585
OrthoDB	1	1.010	-	-		D1326714at2759
OrthoFinder	1	1.000	-	-		FOG0003187
OrthoInspector	1	1.000	-	-		oto89004
orthoMCL	1	0.900	-	-		OOG6_100737
Panther	1	1.100	-	-	LDO	PTHR11502
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1248
SonicParanoid	1	1.000	-	-		X2145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800