DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ston2 and stnB

DIOPT Version :9

Sequence 1:	NP_001028915.1	Gene:	ston2 / 619262	ZFINID:	ZDB-GENE-050913-137	Length:	859	Species:	Danio rerio
Sequence 2:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster

Alignment Length:	955	Identity:	253/955 - (26%)
Similarity:	387/955 - (40%)	Gaps:	240/955 - (25%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MAAT--TSSTTGTPRPG-WVAFSDEESQADEDHLQSSIDQPVLDSSTWVEESCVTDQKSEQTNPW 62
            |||.  |:||.....|. .:...::..::|::....::.:|..::...:|.....:..||.:.|.
  Fly   388 MAAPSGTASTQRATTPDIEITTVEDLPRSDDEDEPEAMQEPETETKPQIEPDTEPEIVSEHSPPT 452

Zfish    63 VQF-------DDKPWSPSPPPPTQEKGPRHSICSSASFWSAVP---PSESSWTTQSEEQSSVSMG 117
            .:.       |.:..:..|.|...:.|....:.||... ||.|   |.|       ||.:...|.
  Fly   453 ERLVTQAALVDGELIAAEPEPEEMDTGLDFPLASSGQL-SANPFASPDE-------EEPNFAPMP 509

Zfish   118 ASSCDLPSLNTEEPASHSPSCP-HSPN----------------SSLCQDDEGMNMDSFNWTANNQ 165
            |:..::.::|..:....:|..| |:.|                .|:.:|:..: ||.|..:....
  Fly   510 AAVANIFAVNDPDSQMETPKAPSHTANIFASDPDEFDAFSAKFDSVKKDNISI-MDGFGGSGAIT 573

Zfish   166 HTNGQAY---------VTSNR----------FASWVTFDEDEDSVLQPPGRPSNIKLHNLNNS-- 209
            .|.|.|:         :::|.          |.:    |:|:...:|.|.|..:::..:.:.|
  Fly   574 PTGGDAWGGSAFGSTTISANACGDTNSADDGFGN----DDDDFYAMQAPARADSVESVDKDFSVV 634

Zfish   210 --PLQDANSNLIPSLFCGQMPERHILDLTPDGNNSIFAFDNTLSKNSVPYNKKNPFLDDDFSNLK 272
              |:.:..|.:.|.|.....|.|.:               |.....|:|....|||
  Fly   635 IRPMAEETSGVAPQLAPPPPPARGV---------------NQAQTTSLPGLTVNPF--------- 675

Zfish   273 PSPINPFSAYFDETDLKTSQGIGLCSEASDVSAFSSPFFGYQNADIKRESILLFPPQKDSAIEKD 337
                                        .|||.|.:|.               .||...:||::.
  Fly   676 ----------------------------EDVSGFPAPG---------------LPPTDGTAIKRT 697

Zfish   338 SVQSSFPVDGLNQLRNIHISDPDRDDSPPLPDSVDEADFTDSTYEP--HHMTPQEGWPMLLRIPE 400
            ..|.: |...|.          |.|.|.||.:.            |  |::.|  ||.|.||.|.
  Fly   698 DSQDT-PQTPLY----------DEDVSQPLEEF------------PRLHYIGP--GWEMQLRQPN 737

Zfish   401 KKNIMSSRHWGPIFVRLTNSGQ---LQLFYEKGLEKPFKEFQLNSQHEISEPKLQNYDENGRVHT 462
            ||.|...|.|..|.|||.....   :||..:.|.::||:|..|...:.:||...|.||:.|::.|
  Fly   738 KKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQELPLQPSYSVSEIGAQQYDQFGKIFT 802

Zfish   463 ISVDHVVYKEKRKIQP-----------KVT---------------------------VVHLPVKE 489
            :.:.::.|||:..::|           |:|                           |.|.|...
  Fly   803 MKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAGDYEGVKEFGSDLKKLGLPVEHAPQSS 867

Zfish   490 QVVKLGTTNYQDFLSFRHALQERLVGLSMDQEGFNWPTTYTEEEVHV------EVRDDFYGILSK 548
            |:.|:|:.||:|...|...::|.|..:...:|.   ..||..|||.|      .|..||.|
  Fly   868 QLFKIGSMNYEDMKQFSVCIEEALFKIPALRER---ALTYKMEEVQVTAVDEITVEQDFEG---- 925

Zfish   549 GDSRILEQLVFTRVNMLAFLNGSPPCSIGLNDIQIKGKEVVSRHDIIPNTTSRWIQLRDCRLHEC 613
               :||:|:...|:..||||.|.|...:|:||:..:|||||.||||||..|..||:|.....|..
  Fly   926 ---KILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGKEVVGRHDIIPVATEEWIRLEAVEFHSV 987

Zfish   614 ADQLEFNESRAITFSPPVGRRFELLRFRT-PFAEKTLPFTLRTVACVMGAEVEMQSWLVMSTGFS 677
            .:|.|:..:|.|.|.||.....||||||. |...:.||..|:...||.|.:||:::.::: .||:
  Fly   988 VNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELPLQLKATWCVSGNKVELRADILV-PGFT 1051

Zfish   678 SNRDPLTLTPCENVAIRYPIPEIW------AKNFRRESVTGEKSLKARFN--KGAS--FGSTSTS 732
            |.:  |...|||:|::|:||||.|      .|:||..||   ||...|..  ||..  .|:..|.
  Fly  1052 SRK--LGQIPCEDVSVRFPIPECWIYLFRVEKHFRYGSV---KSAHRRTGKIKGIERILGAVDTL 1111

Zfish   733 GSEPAMRVTLGTAKYEQAFKSVVWRIGRLPDKNSALGHPHTFFCRLELGSDWEVPPTFECVVEVE 797
             .|..:.||.|.||||...:::|||..|||.:.......|...||:.|.|..::|........||
  Fly  1112 -QESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQLVCRMALTSYDQIPSELAPYAFVE 1175

Zfish   798 FDMLSASASKAAVRSLSV----GDKTDLKKWITYKSHYSYQVAVE 838
            |.|.:...|...|||:||    ||:.. :|::.|.:.:.|:|.:|
  Fly  1176 FTMPATQVSHTTVRSVSVQDSDGDEPP-EKYVRYLARHEYKVGIE 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ston2	NP_001028915.1	Stonin2_N	<62..287	CDD:288839	48/274 (18%)
ston2	NP_001028915.1	AP_MHD_Cterm	522..839	CDD:299401	124/338 (37%)
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603	22/108 (20%)
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	124/339 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587110
Domainoid	1	1.000	184	1.000	Domainoid score	I3354
eggNOG	1	0.900	-	-		E1_KOG2677
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006875
OrthoInspector	1	1.000	-	-		oto40697
orthoMCL	1	0.900	-	-		OOG6_108692
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	1	1.000	-	-		X2217
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.730