DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BCS1L and CG4908

DIOPT Version :9

Sequence 1:	NP_001073335.1	Gene:	BCS1L / 617	HGNCID:	1020	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_609358.1	Gene:	CG4908 / 34360	FlyBaseID:	FBgn0032195	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	254/419 - (60%)
Similarity:	327/419 - (78%)	Gaps:	2/419 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPLSDFILALKDNPYFGAGFGLVGVGTALALARKGVQLGLVAFRRHYMITLEVPARDRSYAWLLS 65
            |.|.|.:..|..||||||||||.|||.|.|:.|||:|.|::.||||.|||||||.||:||.|||.
  Fly     1 MTLPDLVAGLSSNPYFGAGFGLFGVGAAAAILRKGLQGGVILFRRHCMITLEVPCRDKSYQWLLK 65

Human    66 WLT-RHSTRTQHLSVETSYLQHESGRISTKFEFVPSPGNHFIWYRGKWIRVERSREMQMIDLQTG 129
            |:| |.:.:||||||||:::|:::|.|.|.::|:||.|.|...|:|.||:|||:||.|.:||..|
  Fly    66 WITIRGARKTQHLSVETNFVQNDNGTIKTSYDFIPSIGKHLFQYKGNWIQVERTREQQTLDLHMG 130

Human   130 TPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLQ 194
            .|||:||.||.|.::.::|:||||||:|||:..|||||:|||:|:||||||:||||||..||||.
  Fly   131 VPWETVTLTAFGNNKGIYFDILEEARQLALEATEGKTVLYTAMGAEWRPFGHPRRRRPTGSVVLD 195

Human   195 QGLADRIVRDVQEFIDNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDS 259
            :|.:.||:.|.|:||.:..|||.|||||||||||||||||||||||||||||||:|:|||:|::.
  Fly   196 RGTSQRIIADCQDFIKSSLWYTQRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSVCLLNLSER 260

Human   260 SLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEA 324
            .|:||||||||:|||:||::||||:||||:||:...:....:.||.|:|||||||.||||.||||
  Fly   261 GLTDDRLNHLLNVAPEQSIILLEDIDAAFVSREATPQQKSAFDGLNRITFSGLLNCLDGVGSTEA 325

Human   325 RIVFMTTNHVDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLRATN 389
            ||||||||::|||||||:||||:|||||:|||:.:||.:||:.|:.....:.||.|.:.|.....
  Fly   326 RIVFMTTNYIDRLDPALVRPGRIDLKEYIGYCTQYQLEEMFKNFFASSDTTKAEEFGKRVNSFGR 390

Human   390 QISPAQVQGYFMLYK-NDPVGAIHNAESL 417
            ..||||:||:||.:| :.|...|.:.|.:
  Fly   391 SASPAQIQGFFMKHKLSSPQTVIDSCEDI 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCS1L	NP_001073335.1	BCS1_N	24..191	CDD:214980	100/167 (60%)
BCS1L	NP_001073335.1	RecA-like_BCS1	201..353	CDD:410918	109/151 (72%)
CG4908	NP_609358.1	BCS1_N	23..192	CDD:214980	100/168 (60%)
CG4908	NP_609358.1	RecA-like_BCS1	202..354	CDD:410918	109/151 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155206
Domainoid	1	1.000	224	1.000	Domainoid score	I2570
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3193
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1175
Isobase	1	0.950	-	0	Normalized mean entropy	S476
OMA	1	1.010	-	-		QHG53752
OrthoDB	1	1.010	-	-		D365561at33208
OrthoFinder	1	1.000	-	-		FOG0005110
OrthoInspector	1	1.000	-	-		oto91106
orthoMCL	1	0.900	-	-		OOG6_101424
Panther	1	1.100	-	-	LDO	PTHR23070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R132
SonicParanoid	1	1.000	-	-		X279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750