DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BCS1L and Rpt6

DIOPT Version :9

Sequence 1:	NP_001073335.1	Gene:	BCS1L / 617	HGNCID:	1020	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	82/356 - (23%)
Similarity:	142/356 - (39%)	Gaps:	121/356 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    72 TRTQHLSVETSYLQHESGRISTKFEFVPSPGNHFIWYRGKWIR---VERSREMQMIDLQTGTPWE 133
            |.|..:.:|::|                        ::|:..|   :::..|:|::..:......
  Fly     2 TVTNRMEIESAY------------------------HKGEGFRSYYIQKIEELQLVVAEKHQNLR 42

Human   134 SVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFG------------------ 180
            .:.......:.||  .:|.|  ||.|.||:|     :.||...:|..
  Fly    43 RLQAQRNELNAKV--RMLRE--ELQLLQEQG-----SYVGEVVKPMDKKKVLVKVHPEGKFVVDL 98

Human   181 ---------------------------YPRRRRPLNSVVLQQ----------GLADRIVRDVQEF 208
                                       .|.:..||.|:::.:          |..|:.:::::|.
  Fly    99 DKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEV 163

Human   209 ID----NPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSIC-LLSLTDSSL------S 262
            |:    :|:.:...||...:|.|||||||.||:....|:|   .|:.| .:.::.|.|      .
  Fly   164 IELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVA---HHTECTFIRVSGSELVQKFIGE 225

Human   263 DDRLNHLLSVAPQQ---SLVLLEDVDAAFLSRDLAVENPVKYQGLG-----RLTFSGLLNALDGV 319
            ..|:...|.|..::   |::.::::|:...||   :|:     |.|     :.|...|||.|||.
  Fly   226 GSRMVRELFVMAREHAPSIIFMDEIDSIGSSR---IES-----GSGGDSEVQRTMLELLNQLDGF 282

Human   320 ASTEARIVFMTTNHVDRLDPALIRPGRVDLK 350
            .:|:...|.|.||.:|.|||||:||||:|.|
  Fly   283 EATKNIKVIMATNRIDILDPALLRPGRIDRK 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCS1L	NP_001073335.1	BCS1_N	24..191	CDD:214980	24/166 (14%)
BCS1L	NP_001073335.1	RecA-like_BCS1	201..353	CDD:410918	55/169 (33%)
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	77/317 (24%)
		SlyX	<27..>69	CDD:294687	11/45 (24%)
		AAA_16	152..>205	CDD:289934	18/55 (33%)
		AAA	185..317	CDD:278434	49/140 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910