DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BCS1L and Spg7

DIOPT Version :9

Sequence 1:	NP_001073335.1	Gene:	BCS1L / 617	HGNCID:	1020	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	57/207 - (27%)
Similarity:	98/207 - (47%)	Gaps:	15/207 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   203 RDVQEFID---NPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDS----- 259
            ::|:||:|   :|:.|...|....||.||.|||||||:....|:|.|.:  :..||:..|
  Fly   351 QEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQ--VPFLSMNGSEFIEM 413

Human   260 --SLSDDRLNHLLSVAPQQS--LVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVA 320
              .|...|:..|.....:::  ::.::::||....|...........|....|.:.||..:||:|
  Fly   414 IGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMA 478

Human   321 STEARIVFMTTNHVDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPG-QAPSLAENFAEHV 384
            :.|..::..:||..|.||.||:||||.|....:...:..:..::|::.... :..|....|::.:
  Fly   479 TKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRL 543

Human   385 LRATNQISPAQV 396
            .|.|...|.|.:
  Fly   544 ARLTPGFSGADI 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCS1L	NP_001073335.1	BCS1_N	24..191	CDD:214980
BCS1L	NP_001073335.1	RecA-like_BCS1	201..353	CDD:410918	50/161 (31%)
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011
		FtsH_fam	333..787	CDD:273520	57/207 (28%)
		AAA	378..513	CDD:278434	41/136 (30%)
		Peptidase_M41	595..785	CDD:279742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810