Protein Alignment BCR and rga9

DIOPT Version :10

• Sequence 1: NP_004318.3
• Gene: BCR / 613
• HGNCID: 1014
• Length: 1271
• Species: Homo sapiens
• Sequence 2: NP_001342903.1
• Gene: rga9 / 2542132
• PomBaseID: SPAC1952.16
• Length: 670
• Species: Schizosaccharomyces pombe
• Alignment Length: 749
• Identity: 149/749 - (19%)
• Similarity: 262/749 - (34%)
• Gaps: 201/749 - (26%)

Human   592 RAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLV 656
            |.::.....|..:..:..:.|.:..::. ::||:|.....|         ||:|...:..
pombe    12 RDYITGINRAQRLINEGVEQNEKLLQLL-HIRAKSASSCSD---------LLFKSFSKFN----- 61

Human   657 LHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLL----------K 711
                 ||.|.:...:.|..|| .|.|.:.|.:.|      .|:..|.||...:|          |
pombe    62 -----KHHPLNEESNDLPSDA-AIHQLYESYLME------ASLHKKLGEQLNILVINPFANWSKK 114

Human   712 DSFMV-ELVEGA--------RKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMV 767
            .|..| |:|..|        .:..||               :..|:...|.| .||.:..|.:..
pombe   115 YSRRVDEIVSAAIVKINNYNSRFSHV---------------NSKKSNLTDRK-PIPTSRKSNKSD 163

Human   768 DELEAVPNIPLVPD--EELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSP 830
            ....|:..:.:.|.  .:.|.|   |:.:.:....|:.||                 .||.||..
pombe   164 SLASALSQLDINPSNVNKFDGL---INIVDHPYTAEEFAN-----------------VLLKLMKA 208

Human   831 SMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCF---RSFSLTSVELQMLTNSCVKLQTV 892
            |...|      |||:.|  .|||.......:.|..|..|   :...:.....|::.:..::|
pombe   209 STVKR------KSYSHL--GDYELVTNCSLLFEAIKTTFGLEKDSYVVKAGNQLIQHGLIRL--- 262

Human   893 HSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLY--CTLEVDSFGYFVNKAKTRVYRDTAE 955
                |.|.:..:..|      .:.....|..:|....|  ..||||.: :.||...|....|...
pombe   263 ----LGIRRVFENDP------EIDAQFTTKSQQLLKSYHLSILEVDPY-FQVNDPITATNDDPVL 316

Human   956 PNWNEEFEIELEGSQTLRILCY---EKCYNKTKI-------PKEDGESTDRLMGKGQVQLDPQAL 1010
            ..:|               |.|   |:|.::.::       ..|..| .|||.....|.::....
pombe   317 QKYN---------------LAYDNLEQCRHELELYLFMVFKDLEQAE-LDRLNAVKSVLVECSNY 365

Human  1011 QDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMP---SRKQTGVFGVKIA---VVTKRER----- 1064
            ..    ..:.::|.|.:.....|.:.: ||:.|.   ::..||.| :.::   :.||.|.
pombe   366 SG----NFIPSLNSIFIDNLNSFKNLD-SLRDMSTQINKHYTGYF-IPVSNNELSTKDEYLFLQK 424

Human  1065 ----------SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN---------K 1110
                      |.||.|:...::.......|||    :|.|.|....||.|||:.:         .
pombe   425 SSLTEDNLIVSLVPKILAYLLDAYSYERDEEV----LSCVWTTEVPLKDAFDLKSVLRKTDNVES 485

Human  1111 DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNF-AEGIALSD-------PVAKESCMLNL 1167
            .::..:.:..:::|..:|:|...|.|:.|....||..| |.....:|       ..:.:.|:|:|
pombe   486 VLNACVEKYTLSSITCSLRLCLLEFPDSLIRSSFYDYFKAIYTTYTDFEDLDHRLYSIKKCLLHL 550

Human  1168 ----LLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQP 1228
                |..|.|        ::.||...|....:....:.:||.:..|.:|||.:..:.:|...:.|
pombe   551 HSTPLHILEE--------IIRHLSAYAISIRMKDGQIRHLAKIISPCVLRPPDDLNIIPVEDTHP 607

Human  1229 ITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKR 1262
            ..:.    ::::::.:.|...|:..:.|..:.:|
pombe   608 TLLV----IDLINEFENLFADLERPSTPPVEIER 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCR	NP_004318.3	Kinase	1..426
		Bcr-Abl_Oligo	3..75	CDD:430380
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..173
		PHA03307	80..>387	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..247
		Binding to ABL SH2-domain	197..385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..392
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..476
		RhoGEF	502..689	CDD:459876	19/96 (20%)
		PH_BCR_vertebrate	684..877	CDD:270173	45/216 (21%)
		C2_ABR	913..1033	CDD:176068	24/131 (18%)
		RhoGAP_Bcr	1052..1252	CDD:239852	49/238 (21%)
rga9	NP_001342903.1	RhoGAP	422..625	CDD:470621	44/218 (20%)