DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RPL5 and rpl501

DIOPT Version :9

Sequence 1:	NP_000960.2	Gene:	RPL5 / 6125	HGNCID:	10360	Length:	297	Species:	Homo sapiens
Sequence 2:	NP_594180.1	Gene:	rpl501 / 2543642	PomBaseID:	SPAC3H5.12c	Length:	294	Species:	Schizosaccharomyces pombe

Alignment Length:	287	Identity:	141/287 - (49%)
Similarity:	200/287 - (69%)	Gaps:	4/287 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIA 65
            |.|:|.||:..||.|||.|:||||||||||||||||:.|.|||||.||||::||.:||.:.|||.
pombe     1 MPFIKAVKSSPYFSRYQTKYRRRREGKTDYYARKRLIAQAKNKYNAPKYRLVVRFSNRFVTCQIV 65

Human    66 YARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEY 130
            .:|:.||.::..|::.|||:||:|.||.|:.|||.||||:|||.|.:.|:...|||..|..|:..
pombe    66 SSRVNGDYVLAHAHSSELPRYGIKWGLANWTAAYATGLLVARRALAKVGLADKYEGVTEPEGEFE 130

Human   131 NVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVH 195
            ..|:|:..|..|..:||.||.||:||::||||:|||.||||.||||..||||:|.|::|.:.|..
pombe   131 LTEAIEDGPRPFKVFLDVGLKRTSTGSRVFGAMKGASDGGLFIPHSPNRFPGFDIETEELDDETL 195

Human   196 RKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKK- 259
            ||:|.|.:||:||..|:::||:.|:||||..|.:.:..|.:|::|.:|:|.|||:|.::|..|.
pombe   196 RKYIYGGHVAEYMEMLIDDDEERYQKQFSGLIADGIESDQLEDIYAEAYAKIREDPSFQKSGKDA 260

Human   260 ---EVKKKRWNRPKMSLAQKKDRVAQK 283
               :.:..:..:.|::..::|:|...|
pombe   261 AAFKAESLKHTQRKLTAEERKERFNAK 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPL5	NP_000960.2	PTZ00069	1..295	CDD:240254	141/287 (49%)
RPL5	NP_000960.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..297		6/35 (17%)
rpl501	NP_594180.1	PTZ00069	1..291	CDD:240254	141/287 (49%)
		Ribosomal_L18p	26..173	CDD:279233	81/146 (55%)
		Ribosomal_L18_c	193..283	CDD:290906	31/89 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I775
eggNOG	1	0.900	-	-		E1_COG0256
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110649
Inparanoid	1	1.050	294	1.000	Inparanoid score	I717
OMA	1	1.010	-	-		QHG53582
OrthoFinder	1	1.000	-	-		FOG0002632
OrthoInspector	1	1.000	-	-		otm53996
orthoMCL	1	0.900	-	-		OOG6_100789
Panther	1	1.100	-	-	LDO	PTHR23410
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1142
SonicParanoid	1	1.000	-	-		X1734
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860