DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPE65 and ninaB

DIOPT Version :9

Sequence 1:	NP_000320.1	Gene:	RPE65 / 6121	HGNCID:	10294	Length:	533	Species:	Homo sapiens
Sequence 2:	NP_650307.2	Gene:	ninaB / 41678	FlyBaseID:	FBgn0002937	Length:	620	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	201/579 - (34%)
Similarity:	292/579 - (50%)	Gaps:	84/579 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    21 ELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIR 85
            |:..|:..|.:|.||.|:.|||||.|||.::||...|.||||..||||:|..:.|.|||..||:.
  Fly    52 EIVDPIEGHHSGHIPKWICGSLLRNGPGSWKVGDMTFGHLFDCSALLHRFAIRNGRVTYQNRFVD 116

Human    86 TDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFRGVEVTDNALVNVYPVGEDYYACTETN 150
            |:...:..:.:|||:|||||.|.||||.:||.||.:.||....|||:::::||.|:.||..|||.
  Fly   117 TETLRKNRSAQRIVVTEFGTAAVPDPCHSIFDRFAAIFRPDSGTDNSMISIYPFGDQYYTFTETP 181

Human   151 FITKINPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFGKNFSIAYNIVKIPPLQAD 215
            |:.:|||.||.|..::...::|.|...|:|||:...|||||:|....:: ..||.|:..|..:..
  Fly   182 FMHRINPCTLATEARICTTDFVGVVNHTSHPHVLPSGTVYNLGTTMTRS-GPAYTILSFPHGEQM 245

Human   216 KEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDC-- 278
            .||    :.:|...||..:..|.|:|:||||.:|.|.||.|:.::|.:::.: .|.|.|...|
  Fly   246 FED----AHVVATLPCRWKLHPGYMHTFGLTDHYFVIVEQPLSVSLTEYIKA-QLGGQNLSACLK 305

Human   279 -FESNETMGVWLHIADKKRKKYLNNKYRTSPFNLFHHINTYEDNGFLIVDLCCWKGFEFVYNYLY 342
             ||...|:   .|:.|:...| |...|.:..|...|.||.:|.:|.::||:|.::..|.: |.:|
  Fly   306 WFEDRPTL---FHLIDRVSGK-LVQTYESEAFFYLHIINCFERDGHVVVDICSYRNPEMI-NCMY 365

Human   343 L---ANLREN-----------------------WEEVKKNARK--------APQ------PEVRR 367
            |   ||::.|                       ....|:...|        |||      ..|.:
  Fly   366 LEAIANMQTNPNYATLFRGRPLRFVLPLGTIPPASIAKRGLVKSFSLAGLSAPQVSRTMKHSVSQ 430

Human   368 YV----LPLNIDKADTGK------------------NLVTLPNTTATAILCSDETIWLEPEVLFS 410
            |.    :|.|..:|..|:                  ||||:..:.|.|.. ....|.|.||:|..
  Fly   431 YADITYMPTNGKQATAGEESPKRDAKRGRYEEENLVNLVTMEGSQAEAFQ-GTNGIQLRPEMLCD 494

Human   411 GPRQAFEFPQINYQKYCGKPYTYAYGLG--LNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFV 473
               ...|.|:|.|::|.||.|.|.|.:.  ::...|..|.|::|..|....|.|.:.||||||||
  Fly   495 ---WGCETPRIYYERYMGKNYRYFYAISSDVDAVNPGTLIKVDVWNKSCLTWCEENVYPSEPIFV 556

Human   474 SHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEIN--IPVTFHGLF 530
            ..||...|||||:|:.:|..|...:...|::|.||.::|:.|.:...|  :|...||.|
  Fly   557 PSPDPKSEDDGVILASMVLGGLNDRYVGLIVLCAKTMTELGRCDFHTNGPVPKCLHGWF 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPE65	NP_000320.1	RPE65	20..530	CDD:397263	200/577 (35%)
ninaB	NP_650307.2	RPE65	52..617	CDD:281102	201/579 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147632
Domainoid	1	1.000	337	1.000	Domainoid score	I1113
eggNOG	1	0.900	-	-		E1_COG3670
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2389
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S5013
OMA	1	1.010	-	-		QHG59724
OrthoDB	1	1.010	-	-		D342267at33208
OrthoFinder	1	1.000	-	-		FOG0000856
OrthoInspector	1	1.000	-	-		otm40806
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10543
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5415
SonicParanoid	1	1.000	-	-		X319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.850