DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RPA2 and RPA2

DIOPT Version :9

Sequence 1:	NP_001284487.1	Gene:	RPA2 / 6118	HGNCID:	10290	Length:	278	Species:	Homo sapiens
Sequence 2:	NP_001260652.1	Gene:	RPA2 / 35364	FlyBaseID:	FBgn0032906	Length:	246	Species:	Drosophila melanogaster

Alignment Length:	249	Identity:	77/249 - (30%)
Similarity:	123/249 - (49%)	Gaps:	15/249 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    33 GGFGSPAPSQAEKKSRARAQHIVPCTISQLLSATLVDEVFRIGNVEI-----SQVTIVGIIRHAE 92
            |.|.:...:.....|..:.:.|||..:.|::.|.       .||:|:     :...:|.|:|:.|
  Fly     6 GDFNATQTAPTGAASNQKGEGIVPLVVKQIVDAP-------EGNIELFGMQYAMACVVAIVRNVE 63

Human    93 KAPTNIVYKIDDMTAAPMDVRQWVDTDDTSSENTVVPPETYVKVAGHLRSFQNKKSLVAFKIMPL 157
            .:.|.|.|.::|.:.. :|...|::..|......|: ...||||.|..||....|:|:.||::|:
  Fly    64 TSSTKITYTLEDHSGR-IDAHYWLEEGDALKAPEVM-VNNYVKVYGTTRSQGGSKTLMIFKLLPV 126

Human   158 EDMNEFTTHILEVINAHMVLSKANSQPSAGRAPISNPGMSEAGNF-GGNSFMPANGLTVAQNQVL 221
            .|.||..||:|||:||........|:..||....::.|.....:| ...|....:||...|..|.
  Fly   127 LDPNEVCTHLLEVLNARYRAEDYQSKGGAGAGAGASSGSGSIADFTASQSSAIVSGLEPKQQAVF 191

Human   222 NLIKACPRPEGLNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKST 275
            ..||:....||::.::||.:..|:|.|.:...:||:.:||||||::|.|||..|
  Fly   192 QAIKSNVSEEGISRKELKAKFSHISDSELTNILDFMISEGHIYSSIDADHFICT 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPA2	NP_001284487.1	RFA2	33..275	CDD:227560	76/247 (31%)
		RPA2_DBD_D	81..175	CDD:239924	34/93 (37%)
		RPA_C	174..270	CDD:285937	28/96 (29%)
RPA2	NP_001260652.1	RFA2	12..246	CDD:227560	73/239 (31%)
		RPA2_DBD_D	52..144	CDD:239924	31/96 (32%)
		RPA_C	<182..238	CDD:285937	19/55 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9348
eggNOG	1	0.900	-	-		E1_COG5235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37712
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4757
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58029
OrthoDB	1	1.010	-	-		D561832at33208
OrthoFinder	1	1.000	-	-		FOG0003638
OrthoInspector	1	1.000	-	-		otm42288
orthoMCL	1	0.900	-	-		OOG6_102423
Panther	1	1.100	-	-	LDO	PTHR13989
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840