DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1SW and ninaE

DIOPT Version :9

Sequence 1:	NP_001372054.1	Gene:	OPN1SW / 611	HGNCID:	1012	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster

Alignment Length:	331	Identity:	91/331 - (27%)
Similarity:	153/331 - (46%)	Gaps:	37/331 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    27 PVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVA 91
            |:||..| .|:|..:.:|.:..|.:|:......|.||.|.|.:::|::...|.:.|.:. |:.
  Fly    47 PIWAKIL-TAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNT-PMM-- 107

Human    92 SCNGYF---VFGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLA 153
            ..|.||   |.|..:|.:...||:..|..:.||:..::.:||.||.|.......:...||..:..
  Fly   108 GINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAY 172

Human   154 TWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYT 218
            .|.:.....:.|.|||||::|||...|||.|:  :...:...||..|..||.:.:||.|||:||.
  Fly   173 IWFMSSIWCLAPAFGWSRYVPEGNLTSCGIDY--LERDWNPRSYLIFYSIFVYYIPLFLICYSYW 235

Human   219 QLLRALKAVAAQQQESA-------------TTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMV 270
            .::.|:.|.....:|.|             ..:.||.:::::.:|.:..:.:.:.|      |:|
  Fly   236 FIIAAVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTP------YLV 294

Human   271 NN-----RNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMK----MVCGKAMTDESDT 326
            .|     :..||........:.|:|||..||||:|...:.:::..:.:    .|.||....:|..
  Fly   295 INCMGLFKFEGLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGKSSD 359

Human   327 CSSQKT 332
            ..||.|
  Fly   360 AQSQAT 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1SW	NP_001372054.1	7tmA_SWS1_opsin	32..311	CDD:320204	81/299 (27%)
		TM helix 1	34..58	CDD:320204	5/23 (22%)
		TM helix 2	67..89	CDD:320204	5/21 (24%)
		TM helix 3	105..127	CDD:320204	5/21 (24%)
		TM helix 4	149..165	CDD:320204	1/15 (7%)
		TM helix 5	195..218	CDD:320204	11/22 (50%)
		TM helix 6	245..267	CDD:320204	2/21 (10%)
		TM helix 7	279..304	CDD:320204	9/24 (38%)
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	81/299 (27%)
		TM helix 1	53..77	CDD:320207	6/24 (25%)
		TM helix 2	86..108	CDD:320207	5/24 (21%)
		TM helix 3	124..146	CDD:320207	5/21 (24%)
		TM helix 4	168..184	CDD:320207	1/15 (7%)
		TM helix 5	212..235	CDD:320207	11/22 (50%)
		TM helix 6	275..297	CDD:320207	4/27 (15%)
		TM helix 7	308..333	CDD:320207	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910