Protein Alignment RPGR and Rcc1

DIOPT Version :9

• Sequence 1: NP_001030025.1
• Gene: RPGR / 6103
• HGNCID: 10295
• Length: 1152
• Species: Homo sapiens
• Sequence 2: NP_523943.1
• Gene: Rcc1 / 38669
• FlyBaseID: FBgn0002638
• Length: 547
• Species: Drosophila melanogaster
• Alignment Length: 679
• Identity: 153/679 - (22%)
• Similarity: 244/679 - (35%)
• Gaps: 199/679 - (29%)

Human     8 MPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK 72
            ||...|:.....:..||..|.|. .:..:..||......:  |.||  :.:.|:.:.||||||..
  Fly     1 MPRRKALTNNNNAGEAEQQPPKA-KRARIAFHLELPKRRT--VLGN--VLVCGNGDVGQLGLGED 60

Human    73 SAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFT 137
            ....|.....|..|:.|.::| |..|.||.|:.|::|:.|.|:||.|| .||.|..:........
  Fly    61 ILERKRLSPVAGIPDAVDISA-GGMHNLVLTKSGDIYSFGCNDEGALG-RDTSEDGSESKPDLID 123

Human   138 SEHKIKQLSAGSNTSAALTEDGRLFMWGD--NSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200
            ...|...:|||.:.||.|.||||:|.||.  :|.|.:||....|...|..:..|.....|:.|..
  Fly   124 LPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGAD 188

Human   201 HSAFVTTDGELYVFGEPENGKLG-------------------LPNQLL----------------- 229
            |...:||.|:::..|..|.|:||                   .|.||:
  Fly   189 HLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCT 253

Human   230 -------------GNHRTPQLVSEIPEK-------------VIQVACGGEHTVVLTEN-AVYTFG 267
                         |.:...||..|...|             :..:|.|..|||:||.: .....|
  Fly   254 FMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVG 318

Human   268 LGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLE 332
            ..::|:||||.......:|.:::.:.::.:| :.|||..:..:|..|.:|::|.|.:.:||:|..
  Fly   319 RPEYGRLGLGDVKDVVEKPTIVKKLTEKIVS-VGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDG 382

Human   333 NFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLT 397
            :.....|..:..|.....:.|.:.||.|                           |.||..:.
  Fly   383 DDELEPIVVVSKNTQGKHMLLASGGGQH---------------------------AIFLVKAD-- 418

Human   398 SGNVLQRTLSARMRRRERERSPDSFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSE 462
                         ::.::|..|...|                                ..|.:|:
  Fly   419 -------------KQDQKENVPVKVS--------------------------------GSSSISK 438

Human   463 QDLMQPEEPDYLLDEMTKEAE-IDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQ 526
            :|...|:      |.:.|||| :|.....|:|                    ..|.|...|:.|.
  Fly   439 KDKTPPQ------DNVDKEAENVDKQEQKENL--------------------PAKASTSSKKNKT 477

Human   527 QTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKE 591
            .     .||.|..|.::.|:.|:    ||....|            |:|    |.::::.|.:.:
  Fly   478 P-----PQDNADKEAENVDKQEQ----KENLPAK------------AST----SSKKIKTPPQDD 517

Human   592 GAEDSKGNGIEEQEVEANEENVKVHGGRK 620
            .||:.:....:|...:..::.....||:|
  Fly   518 AAEEVEEESAQEPTPKKAKKPAAKRGGKK 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPGR	NP_001030025.1	RCC1	<38..312	CDD:332518	91/338 (27%)
		RCC1	314..360	CDD:306840	12/45 (27%)
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	17/49 (35%)
		RCC1	92..141	CDD:278826	17/49 (35%)
		RCC1_2	131..158	CDD:290274	14/26 (54%)
		RCC1	144..193	CDD:278826	16/48 (33%)
		RCC1_2	182..209	CDD:290274	8/26 (31%)
		RCC1	363..414	CDD:278826	14/77 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850