DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RP1 and CG1647

DIOPT Version :9

Sequence 1:	XP_016869210.1	Gene:	RP1 / 6101	HGNCID:	10263	Length:	2163	Species:	Homo sapiens
Sequence 2:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	1479	Identity:	276/1479 - (18%)
Similarity:	496/1479 - (33%)	Gaps:	504/1479 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   236 PGNYDIQKYLLPAR-------LPGISQRVYP-KGNAKSESRKISTHMSSSS----------RSQI 282
            ||...|   |||..       .|.:||::|. .|...|...|:...:.|..          |...
  Fly    28 PGKVPI---LLPNEEDTIDLDEPRMSQKIYELVGFTVSVDDKMPQTICSQCVDKINDFYEFREMC 89

Human   283 YSVSSEKTHNNDCYLDYSFV-PEKYLALEKNDSQNLPI----------------YPSEDDIEKSI 330
            |: ::::|.|   .|....: |.:.:.|::...:..||                :|..::::..:
  Fly    90 YA-TNKQTRN---LLGLKQIEPARLIDLKRIVKEERPISGAVGKRGRKRKGEESWPKNNNVKPQV 150

Human   331 IFNQDGTMTVEMKVRFRIKEEETIKW-----------TTTVSKTGPSNNDEKSEMSFPGRTESRS 384
                               ::|:..|           |:.|||..|...||.:|.....:...:.
  Fly   151 -------------------KKESFVWHKKQKLQPSQITSLVSKREPEIKDEPAEQDTSLKGPPKK 196

Human   385 SGLKLAACSFSADVSPMERSSNQEGSLAEEINI---------------------QMTDQVAET-- 426
            :|.| :.||...:....:..:::..||....:|                     |:..::::|
  Fly   197 AGRK-SICSVCGEKFLSKELADEHKSLVHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLSKTPY 260

Human   427 ----CSSASWENATVDTDIIQGTQDQAKH-RFYRPPTPGLRRVRQKKSVIGSVTLVSETEVQEKM 486
                |.| |..||...|          :| |.:.||||....|..::..:...|.|:
  Fly   261 KCPLCES-SVANAYAFT----------RHLREHTPPTPVQLLVLDRECPLCKKTFVT-------- 306

Human   487 IGQFSYS------EERESG------ENKSEYHMFTHSCSKMSSVSNKPVLVQINNND-QMEESSL 538
              .|.|:      .:|:.|      ..::.|.....:|.|:....:|.::.|:..|: ||
  Fly   307 --NFFYNTHRCAIRKRKCGGCSRTLNTEAAYMRHAPTCPKIYLNHSKHIMPQVVTNEAQM----- 364

Human   539 ERKKENSLLKSSAISAGVIEITSQKMLEMSHNNGLP--STISNNSIVEEDVVDCVVLDNKTGIKN 601
                   |:|:        ||..:.:       |||  :|:..:.:::|.:...|||:..:
  Fly   365 -------LIKN--------EIEEELL-------GLPPATTVPPDFVIDEGMQPVVVLERLS---- 403

Human   602 FKTYGNTNDRFSPISADATHFSSNNSGTDKNISEAPASEASSTVTA-----RIDRLINEFAQCGL 661
                       ||:       ..::||||:.:  |..|:.|..|:|     |:|:|:
  Fly   404 -----------SPL-------LRSSSGTDQLV--AAKSKNSDRVSARNYLKRVDQLL-------- 440

Human   662 TKLPKNEKKILSSV-----------------ASKKKKKSRQ----------QAINSRYQDGQLAT 699
                ||....|.|:                 |....:..|.          ||.|...|:.|..|
  Fly   441 ----KNTINTLVSIKHEPEVHINDTGPPRGQAESDPEPERNEEHPSFGDDIQAANDECQECQPET 501

Human   700 KGILNKNERINTKG--RITKEMIVQDSDSPLKGGILCEEDLQKSDTVIESNTFCSKSNLNSTISK 762
                 ::::|:...  .|....:.|:.          |.|..:..|.::....    .|...|:|
  Fly   502 -----ESDKISVAACDDIPSVSVKQEP----------EYDGYEKQTGVKQEPL----KLKLKITK 547

Human   763 NFHRNKLNTT------QNSKVQGLLTKRKSRSLNKISLGAPKKREIGQRDKVFPHNESKYCKSTF 821
            |  ..|||::      :..:..|..:|:|            |||:..:|:|. ..||::.|::..
  Fly   548 N--HGKLNSSLIDDLDEAGQAFGRSSKKK------------KKRKHKEREKE-ASNETENCRTES 597

Human   822 ENKSLFHVFNILEQKPKDFYAPQS--QAEVASGYLRGMAKKSLVSKVTDSHITLKSQKKRKGDKV 884
            :|:....:    :|:|.| |||::  ...:..........:|..|:..|..: ::||:..|.:::
  Fly   598 QNQPAIKI----KQEPVD-YAPEATVMTTIPMTQFESSLNESERSEEVDEAM-IQSQEDVKPNRM 656

Human   885 KASAILSKQHATT---RANSLASLKKPDFPEAIAHHSIQNYIQSWLQNINPYPTLKPIKSAPVCR 946
            :...::...:.|:   .|....:|::.:  ||....|:..              :|.:||  ..|
  Fly   657 ELDRMMQISNVTSGVDMAEEAMALERAE--EACPEDSLHK--------------VKSVKS--TAR 703

Human   947 NETSVVNCSNNSFSGNDPHTN---------SGKISNFVMESNKHITKIAGLTGD----------- 991
            ..|.  .....::|  .|.||         ||: |.|.|.|.|...:..|. ||
  Fly   704 KSTG--GAERKTYS--PPRTNTLPQIVAVVSGE-SAFNMISIKPEPRNLGY-GDEEPEDQRETTE 762

Human   992 ----NLCKEGDKSFIANDTGEEDLHETQV---GSLNDAYLVPLHEHCTLSQSAINDHNTKSHIAA 1049
                |...|.:|.:|    |..||.:..|   ..|:...:..:|.: .|.:|..:|.:.....|:
  Fly   763 EINHNDMMEEEKEYI----GSLDLSDVSVKQERELDICEIDAVHRN-GLEKSDEDDDDGNEDSAS 822

Human  1050 EKSGPEKKL-------VYQEINLARKRQSVEAAIQVDPIE---EETPKDLLPVLMLHQLQASVP- 1103
            .....|:.:       :|:||.|             .|:|   |.:.|||....|..::..::|
  Fly   823 SADEAEEAMERDTEERIYREIEL-------------PPLELQNESSRKDLESERMDTEVSTALPA 874

Human  1104 -----------GIHKTQNGVVQMPGSLA-------GVPFHSAICNSSTNLLLAWLLVLNLKGSMN 1150
                       |:.|::....    ||.       .||..||.|::.        :..::..|.:
  Fly   875 SETPSQTRDVLGVEKSEASAF----SLVITNICSQAVPQPSAACSND--------IECSIGPSPS 927

Human  1151 SFCQVDAHKATNKSSETLALLEILKHIAITEEADDLKAAVANLVESTTSHFGLSEKEQDMVPIDL 1215
            :..:..:|...|..|.... |:....:||..::......|:....|:.|    ....:|:.|  .
  Fly   928 TTNEPHSHTVENVQSPAND-LQTSAQVAIAAQSQPDPCIVSQPAASSES----QADTKDLPP--A 985

Human  1216 SANCSTVNIQSVPKCSENERTQGISSLDGGCSASEACAPEVCVLEVTCSPCEMCTVNKAYSPKET 1280
            ::...|.|.:|:|....:|...  :|::...|..|:.|...|....|.:|..:...|::. |..:
  Fly   986 ASQIQTFNTESLPIHVHSETED--NSIENDASYLESRAQVDCQSAGTENPSVVLEQNESL-PSGS 1047

Human  1281 C------NPSDTFFP---SDGYGVDQTSMNKACFLGEVCSLTDTVFSDKACAQKENHTYEGACPI 1336
            |      |||....|   .:...:|:..|    ..|....|. ||..|              .|.
  Fly  1048 CVSPIPENPSPGNSPPQHDESESLDKPEM----AAGSAYCLA-TVSLD--------------APK 1093

Human  1337 DETYVPVNVCNTIDFLNSKENTYTDNLDSTEELERGDDIQKDLNILTDPEYKNGFNTLVSHQNVS 1401
            |...:.:..|                          |....|.|..:|.|.:|..|..:|.|.::
  Fly  1094 DTEALALPPC--------------------------DAAIIDSNYTSDEEQQNVLNHELSEQQLA 1132

Human  1402 NLSSCGLCLSEKEAELDKKHSSLDDFENCSLRKFQDENAYTSFDMEEPRTSE--EPGSITNSMTS 1464
            .:....|.:.|                                  |:|...|  .||..:..:..
  Fly  1133 IMEHRQLLVHE----------------------------------EQPALLEVIPPGLSSRPIEE 1163

Human  1465 SERNISE----LESFEE-----LENHDTDIFNTVVNGGEQATEELIQEE 1504
            :|..|:|    ||..||     ..|.|::|.....|......|..:|::
  Fly  1164 TENRINEQQQDLEQGEERPPRFQANDDSNINEIAENNNNANIERELQDD 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RP1	XP_016869210.1	None
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	18/77 (23%)
		C2H2 Zn finger	203..224	CDD:275368	4/20 (20%)
		C2H2 Zn finger	233..253	CDD:275368	1/19 (5%)
		C2H2 Zn finger	262..282	CDD:275368	8/30 (27%)
		C2H2 Zn finger	297..314	CDD:275368	4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900