Protein Alignment HCN2 and tax-2

DIOPT Version :9

• Sequence 1: NP_001185.3
• Gene: HCN2 / 610
• HGNCID: 4846
• Length: 889
• Species: Homo sapiens
• Sequence 2: NP_492427.3
• Gene: tax-2 / 172723
• WormBaseID: WBGene00006525
• Length: 800
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 125/553 - (22%)
• Similarity: 238/553 - (43%)
• Gaps: 77/553 - (13%)

Human   205 HPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVS---DTFFLMDLV-----L 261
            |||..|...|...:.|..:.|...||:. :.:..:|...|:.:.:|.   |..:::|::     |
 Worm   215 HPYGRFYMTWLSLVTLCFLFNAFCIPLR-SSYPYQTADNWMYWFIVDYSCDLVYVIDMLLIKPRL 278

Human   262 NF-RTGIVIEDNTEIILDPEKIKKKYLRT-WFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALR 324
            .| |.||.:    :|..|.:   :.||.| .|.:|.:|.:|.|.::....|   ..:::..|.|:
 Worm   279 RFTRGGIQV----KIYKDTQ---RHYLMTRTFKLDILSILPTDLMYFFFGK---MPIWRINRVLK 333

Human   325 IVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVP 389
            |..|..:..:|               :..|...|     .:||...:|.|:.:.|.:.|:.:.:.
 Worm   334 INSFWLLFDML---------------DNSFANPY-----AIRIARTLSYMIYIIHCNSCVYYKLS 378

Human   390 MLQDFPRNCWVS-----INGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMI 449
            .||.|.:..::.     :|..|.::....|....:...:.....| ...||.::.:......|.:
 Worm   379 ALQAFGQIAYLENGKWYLNKWVYNNQGNAYIRCFYFTAAVATSTG-NNPAPTNVIEYIYMTCSWM 442

Human   450 VGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMF 513
            :|...:|:.:|....::.:.:.:|.::|.|............|..:...::.|::.:.: |.|..
 Worm   443 MGVFVFALLLGQIRDIVSNANRNREEFQRKMDLALGECKKLGLKMETTNRVRDWFIYTWQQQKTL 507

Human   514 DEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIG 578
            ||..::.:|...|:.::........::.:.||.:.|...:..::.||:..:|.|||.|..:|.:|
 Worm   508 DEKKLIEKLPLKLQTDLALSVHYTTLSKVQLFQDCDRALLRDLVLKLRPVIFLPGDMICLKGDVG 572

Human   579 KKMYFIQHGVVSVLTKGNKE---MKLSDGSYFGEICLLTRG---RRTASVRADTYCRLYSLSVDN 637
            |:||.|..|::.|:...:.|   .:|:.|:.||||.||..|   |||||:||..||.|:.|:.::
 Worm   573 KEMYIINQGILQVVGGDHNEKIFAELAQGAVFGEISLLAIGGNNRRTASIRAKGYCTLFVLAKED 637

Human   638 FNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHD-------------------LNSGVF 683
            .|:|:..||..:......|...| :..||:.....|::..                   |.:.:.
 Worm   638 LNDVIRYYPQAQTILRRKAAAML-KNDKKSDEKTEKIKAQAELEDRCKINPRQVPKLITLIANMT 701

Human   684 NNQENAIIQEIVKYDREMVQQAELGQRVGLFPP 716
            ...||..:||:.|...|   :.|..:|..::.|
 Worm   702 EMNENKGVQELKKVIEE---ETEKSRRQSIYYP 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..159
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		3/3 (100%)
		Ion_trans_N	167..209	CDD:285597	3/3 (100%)
		Ion_trans	229..474	CDD:278921	49/259 (19%)
		Crp	538..>673	CDD:223736	47/140 (34%)
		CAP_ED	544..652	CDD:237999	43/113 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..889
tax-2	NP_492427.3	Ion_trans	221..467	CDD:366146	52/277 (19%)
		CAP_ED	538..652	CDD:237999	43/113 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840