Protein Alignment ROS1 and Sdr

DIOPT Version :9

• Sequence 1: XP_011534351.1
• Gene: ROS1 / 6098
• HGNCID: 10261
• Length: 2357
• Species: Homo sapiens
• Sequence 2: NP_001287331.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Alignment Length: 1070
• Identity: 190/1070 - (17%)
• Similarity: 342/1070 - (31%)
• Gaps: 384/1070 - (35%)

Human   788 TDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDG 852
            |.:|.||:|...|:.  .|.|.      ||::|...|                     ..::||.
  Fly    60 THVVGHVRLAYVDLT--DVSGN------YSLDSLASN---------------------VTEISDY 95

Human   853 LLYWLVQDSQCIHLYT--------AVLRGQSSTGDTTITEFAAWSTSEISQNALMYYSGRLFWIN 909
            |:.:     :|..|.:        .::|||....|               |.:|:.|..|
  Fly    96 LMVY-----RCTGLISLQSIFPRLRIIRGQELLFD---------------QYSLVVYENR----- 135

Human   910 GFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKV----IPDSVQESSFRIEG 970
                 ..:|:|      ::|..|. |...|:....||   ..|...|    :..:.....|.::.
  Fly   136 -----NLRELG------LVELLRI-QSGFIRVESNPL---LCFVETVDWIYLMGNATRQHFSLKH 185

Human   971 NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWG 1035
            |....|....|..:.|:       ||..:|    ||:               .:|::.|
  Fly   186 NRPQSQCPLCGSLSADF-------EFIRNS----SER---------------CWNVNTT------ 218

Human  1036 KGPKTSLSLRAPETVPSAPENPRIFILP----------SGKCCNKNEVVVEFRWNKPKHEN---- 1086
                   .||        |:.||:...|          :||||:.|.|...:..|.....|
  Fly   219 -------QLR--------PQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQNCSLCANYQGR 268

Human  1087 -GVLTKFEIFYNIS-NQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKG---- 1145
             |.:.:....|.:: .:.|.::.|.:   :...|.:..:|.....|    ..|.....:||
  Fly   269 MGCVNQCVASYELNKRRCIGHRECRE---LGRIPLIRGYQCVKKCP----GNQKEILVAKGIIHC 326

Human  1146 ----PGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEM- 1205
                .|.:.  ||| .:::......:|:.|:..:.|         |...|:::.|:    :|.:
  Fly   327 QVECNGDFH--VKS-AADLEVLQDCVTINGSLTIEL---------TNIKEKIVDAL----ENALA 375

Human  1206 ------GYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDV 1264
                  ||      |.::|     |::|...:.:.::..|..|.:..:.| ||....|      .
  Fly   376 SVKEITGY------LKVIH-----SAQLMSLTFLQNLDAIRGDKLVENKY-ALYVVNN------Y 422

Human  1265 DLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATN 1329
            .||| :..|..:.|..|.:  :.|.:.|   ||.:.::                 |: ||.:..:
  Fly   423 HLEH-IWPPNHLVIIQRGT--LFFHLNP---RLCYEKI-----------------HQ-LQGSLKS 463

Human  1330 QQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFA------KAQEIWA---------MDLEGCQ 1379
            .:|             :|.|.....||.|:.:...|      |.:::.:         ||.||.:
  Fly   464 GEN-------------ISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRIILDYMDWEGME 515

Human  1380 CWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGA---IVSQVKALRSRHILA 1441
                               |:.|...::......:..:|..:.|.|.   ::..|.....||::
  Fly   516 -------------------TLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSRRHVI- 560

Human  1442 YSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGI--TSPTPTYLVYYAEV 1504
              |.::|:...|:.          :...|.|...|::. |.:.:.::..  ..|:|...:|
  Fly   561 --SGLKPYTQYAYF----------VKTLTRTEYHIQID-AYSKIGYFQTLPDRPSPVLRIY---- 608

Human  1505 NDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPE 1569
                .||::..:||           |..:........:|||:. ..|.....||  .|.||.|
  Fly   609 ----GSSEISSQIL-----------LHWWPPRRPNGVIKNYFV-TAEKYNATKE--AKDKNYV-- 653

Human  1570 AVQLINT-TVRSDTSLIISWRESHKPNGP----KESVRYQLAISHLALIPET-PLRQSEFPNGRL 1628
            .|:|.|. .:..:.:.::.:....:|:..    ||.:.|:.|:.:|..:... ..|:.||.
  Fly   654 NVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQITYEDALPNLIYVSRNHDYRRKEFE---- 714

Human  1629 TLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSL--VPENTSLQFNWKAPLN 1691
                           ||:         ...|.::::....|.:|.:.  .|.|.:|.....|.:|
  Fly   715 ---------------KVI---------NYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAIN 755

Human  1692 VNLIRFWVE--------LQKWKYNEFYHVKTSCSQGPAYVCN----------------------- 1725
            ....|...|        |.:.||. ..|....|....|.|..
  Fly   756 YENYRLNSEKKQRDLQDLDQHKYT-IRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHF 819

Human  1726 --ITNLQPYTSYNVRVVVVYKTGENSTSLP 1753
              ::.|:|.|.|.:.:....:...|..|.|
  Fly   820 YCLSQLEPETHYRITIRACVEGVVNGCSTP 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ROS1	XP_011534351.1	None
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	35/181 (19%)
		Furin-like	209..332	CDD:279142	28/165 (17%)
		Recep_L_domain	347..461	CDD:279382	32/168 (19%)
		FN3	491..578	CDD:214495	16/118 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870