DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ROBO2 and fra

DIOPT Version :9

Sequence 1:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens
Sequence 2:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster


Alignment Length:1746 Identity:374/1746 - (21%)
Similarity:583/1746 - (33%) Gaps:542/1746 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    27 TLSKLTRTPWKGKPW---------KGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNC------- 75
            |.::.:||.|.   |         ..||.|..:..  .....|.|.:|.:|....|.|       
  Fly     4 TTNRSSRTLWN---WLLSSCLIFQLIGSSLASQAL--SFTLEPQDAVVPEGHSVLLQCAGTASIG 63

Human    76 -----KAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVC- 133
                 |:....:.:|.|. .||:.:....|   :.|..|.:|||:...:...|..   .|:|.| 
  Fly    64 RGGKSKSNLPSSVSIRWRGPDGQDLVIVGD---TFRTQLKNGSLYISSVEENRGL---TGAYQCL 122

Human   134 VARNYLGEAVSRNASLEVALLRD-DFRQNPTDVVVAAGEPAILECQPPRGH----PEPTIYWKKD 193
            :....:|..:||.|.  ||::|. |..|:..:..:..|:.|...|.....:    .:.::.|.||
  Fly   123 LTAEGVGSILSRPAL--VAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKD 185

Human   194 KVRID-DKEERISIRGGKLMISNTRKSDAGMYTC-----------VGTNMVGERDSDP-AELTVF 245
            .:.:. ||...:.:..|.|.|.....||.|.|.|           ..||:..::.||| ||.:| 
  Fly   186 DLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSV- 249

Human   246 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP----RGRYDIKDDYTLRIKKT 306
             .|:||..|..:.|.|.:.|...|...|.|:|.::|.::..||.    ..|:.|....:|:|...
  Fly   250 -APSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSA 313

Human   307 MSTDEGTYMCIAENRVGKMEASATLTVRARPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPA 371
            ...|.|.|.|.|.|.|..::|.||:.|:    .||:|:..|:|....:.......|:..|.|:|.
  Fly   314 EDIDSGNYQCRASNTVDSLDAQATVQVQ----EPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPV 374

Human   372 VFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT 436
            :.|.|.|  :|:.||...|      :....:|.|..:..||||.:.|.....|||:.|.|:|.|.
  Fly   375 IRWLKNG--DLITPNDYMQ------LVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVV 431

Human   437 ----------------------DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWL 479
                                  |.||.|..|.            :....|:.|:.|         
  Fly   432 PQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPF------------NSGEQLRTKSGG--------- 475

Human   480 KEGFTFPGRDPRATIQEQGTLQI----------------KNLRISDTGTYTCVATSSSG------ 522
              .|.||..|......:.||.::                :...|.:.|:...:...|..      
  Fly   476 --SFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDD 538

Human   523 -----ETSWSAVLDVTESG------------ATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQ 570
                 :.:..|:|:..:.|            :...|:......|..|..|:......:.......
  Fly   539 DYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLD 603

Human   571 PGTPGTLPAS-----AYIIEAFSQSVSNSW----QTVANHVKTTLY------------------- 607
            .|....||:.     |.|::  |:.|:.||    |...:.|..|:|                   
  Fly   604 SGLQARLPSQPRDLVAQIVK--SRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDD 666

Human   608 ---TVRGLRPNTIYLFMVRAINPQG---LSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLV 666
               .::.|.|...|.|.|.|....|   .|.|..:|.........||.....:.:..||      
  Fly   667 QQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKE------ 725

Human   667 RLHNPVVLTPTTVQVTWTVDRQPQFIQG----YRVMYRQT-SGLQATSSWQNLDAKVPTERSAVL 726
                        :.|.|   .:|....|    |||.|.:. ||......        .|...|||
  Fly   726 ------------IYVKW---EEPTVTNGEILKYRVYYSENDSGADLYHD--------STALEAVL 767

Human   727 VNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPP 791
            ..|:....|.|.|.|:.....|..|....|:|....||.||.:|| |.|.|  |:||:|.|:||.
  Fly   768 TELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVT-LEVTS--SSSITVHWEPPA 829

Human   792 PDHQNGIIQEYKIWCLGNETRFH------INKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVG 850
            .:.:||.|..|||       |:.      ..|:..|.||...:..|....:|:|::||.|..|.|
  Fly   830 EEDRNGQITGYKI-------RYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSG 887

Human   851 VKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRK 915
            ..:|     ..|.|.:     .|.:.|  |.|..:|.:|:...||       .:|.|:|...:..
  Fly   888 PFTE-----WNRANTL-----ENDLDE--TQVPGKPIWISIHPGA-------NNIALHWGPPQHP 933

Human   916 GLS--NYAVTFQRG--DGGL--MSNGSRPGLLNAGDPSYPWLADSWPATSLPVNN-SNSGPNEIG 973
            .:.  ||.:.:.||  |...  :....|..:|...:.:..::      .||...| ...||....
  Fly   934 EIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYV------VSLRARNVKGDGPPIYD 992

Human   974 NFGRGDVLP---PVPGQ---GDKTATMLSDGAIYSSID--------FTTKTSYNSSSQITQATPY 1024
            |....|..|   |.|.:   |.:..||.|...:...||        .|....|..|..||.:..|
  Fly   993 NIKTRDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGITGSNRY 1057

Human  1025 A---TTQI------LHSNSIHELAVDL----PDPQWKSSIQQKT--------------------- 1055
            .   ||.:      |..|:.:|.||.:    .:..|..|:...|                     
  Fly  1058 RYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNP 1122

Human  1056 ---------------DLMGFG-YSLPDQNK-----------GNNALLYIPDY------------R 1081
                           .:.|:. |...|..|           |...:|.:|:.            |
  Fly  1123 PTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQAR 1187

Human  1082 LAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSGGKGGKKK-----------------------K 1123
            ..:| :|..|.:....: |||:..:.:...:::.|...:|.                       :
  Fly  1188 TTKG-ANNAPFSALVSY-TTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLLCR 1250

Human  1124 NKNSSKP-------QKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQT 1181
            .|..|.|       |||      ||.:|.||                       |.|        
  Fly  1251 RKPQSSPEHTKKSYQKN------NVGVPKPP-----------------------DLW-------- 1278

Human  1182 YLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPRE------EMQPMLQAHLDE 1240
             :|.. :.||:..|..:.|       .:|..|.|..|:..|| .||.      |::..:..|:  
  Fly  1279 -IHHD-QMELKNIDKGLHT-------VTPVCSDGASSSGALT-LPRSVVHSEYEVETPVPGHV-- 1331

Human  1241 LTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLE------TDVADD-------DADD 1292
                             :|:...:..||  ||::.::...:|      |..:..       :|..
  Fly  1332 -----------------TNSLDKRSYVP--GYMTTSMNGTMERPQYPRTQYSHQNRSHMTMEAGL 1377

Human  1293 EEEALEIPRPLRALDQTPGSSMDNLDSSV--TGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIF 1355
            .:::|..|:. .::.|||.......|::.  .|:...|.|..           |::.||..|...
  Fly  1378 SQQSLTQPQS-NSMAQTPEHPYGGYDANFCNAGNAAAGNGCV-----------STIESSKRGHPL 1430

Human  1356 ASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKK 1420
            .|.|     |......|   ..|.:|:...|.|.  ||:..||:...|.::|.        |.:.
  Fly  1431 KSFS-----VPGPPPTG---GATPVTKHTPAVTI--RPQNQSPYKKPSFSAAT--------PNRL 1477

Human  1421 HKGGRMDQQPALPHRREGMTDDLPPPPDPPPGQGLRQQIGPS-------QQAGNVE 1469
            ..||      ::.|    .||::             |::.||       |:..|:|
  Fly  1478 QGGG------SVVH----STDEI-------------QRLAPSTSTEELNQEMANLE 1510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ROBO2XP_011532283.1 Ig1_Robo 53..152 CDD:143317 25/112 (22%)
Ig 160..244 CDD:325142 24/100 (24%)
Ig 265..333 CDD:325142 22/71 (31%)
Ig4_Robo 355..444 CDD:143203 29/110 (26%)
IG 451..532 CDD:214652 14/107 (13%)
FN3 549..642 CDD:238020 26/126 (21%)
FN3 673..758 CDD:238020 22/89 (25%)
FN3 766..859 CDD:238020 34/98 (35%)
PTN13_u3 <1374..>1431 CDD:318742 13/56 (23%)
fraNP_523716.2 Ig 36..140 CDD:299845 26/111 (23%)
Ig <180..222 CDD:299845 13/41 (32%)
IG_like 257..340 CDD:214653 25/82 (30%)
IGc2 264..327 CDD:197706 18/62 (29%)
I-set 344..430 CDD:254352 28/93 (30%)
Ig 363..428 CDD:299845 23/72 (32%)
FN3 611..703 CDD:238020 20/93 (22%)
FN3 711..799 CDD:238020 26/116 (22%)
FN3 806..897 CDD:238020 35/105 (33%)
FN3 908..989 CDD:238020 18/93 (19%)
FN3 1011..1097 CDD:238020 20/85 (24%)
FN3 1109..1205 CDD:238020 11/97 (11%)
Neogenin_C 1273..1521 CDD:284094 66/353 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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