DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ROBO2 and robo3

DIOPT Version :9

Sequence 1:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens
Sequence 2:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster


Alignment Length:1495 Identity:451/1495 - (30%)
Similarity:668/1495 - (44%) Gaps:270/1495 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    13 LELLFVLMLFLSGPTLSKLTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKA 77
            ::|.||.::|     |.|.|..              |...||||||||.|..|.:.||.||||||
  Fly     1 MDLRFVFIVF-----LLKWTHA--------------QGSHPPRIVEHPIDTTVPRHEPATLNCKA 46

Human    78 EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEA 142
            ||.|||||:|||||..:   |..|.|||:.||:|.||||::|:.|| :.|.|.|.|.|:|.||.|
  Fly    47 EGSPTPTIQWYKDGVPL---KILPGSHRITLPAGGLFFLKVVNSRR-ETDAGIYWCEAKNELGVA 107

Human   143 VSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID---DKEERI 204
            .||||:|:||:|||:||..|.:..:|.|:.|:|||..|||.||||:.|||...::|   .|..||
  Fly   108 RSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRI 172

Human   205 SIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRC 269
             :.||.|.|.:.|::|.|.|.|:..|.||.|:|..|.|.|..:|..:|.|.:|.|||..:|.|.|
  Fly   173 -VDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVHVKPYIIRGPHDQTVLEGASVTFPC 236

Human   270 QVQGDPQPTVRWKK--DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 332
            :|.|||.|.|.|.:  ...::|..|..:.:|.:||:::....|||.|.|.|:|.||.:.|..|||
  Fly   237 RVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLT 301

Human   333 VRARPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSV 397
            |    .|||:|:.||..:.|..|...:|.|...|||:|.:||..:.:..|:||..|  |..|...
  Fly   302 V----YAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIKNNSTLIFPGAP--PLDRFHS 360

Human   398 SPTGD----LTITNIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA 457
            ..|.:    ||:|..||:|....| |.|:....||.::.||.: |...|||||||:.||.||||.
  Fly   361 LNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSL-DSQEDRPPPIIISGPVNQTLP 424

Human   458 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNL-RISDTGTYTCVATSSS 521
            :...|.|:|||.|.|.|.|||.::|.... ...:..|...|.|.|.:| |..|.|.|||||:|.:
  Fly   425 IKSLATLQCKAIGLPSPTISWYRDGIPVQ-PSSKLNITTSGDLIISDLDRQQDQGLYTCVASSRA 488

Human   522 GETSWSAVLDV---TESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA-- 581
            |:::||..|.:   |.......:..:.:..|..|.:|::.:.|.:::|:.|.  |.....||:  
  Fly   489 GKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASALTIVWP--TSDKAGASSFL 551

Human   582 -YIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 645
             |.:|.:..:.|.:|..:|:.:...::||..|.....|:|:|||.|..|.|.|||:|:|:....:
  Fly   552 GYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKL 616

Human   646 SPPAQGVDHRQV-QKELGDV--LVRLHNPVVL------TPTTVQVTWTVDRQPQFIQGYRVMYRQ 701
            .....|.:.... |..|.||  |::.::.|.|      ..||.:::|.:| ..|:|:|:.:..|:
  Fly   617 VGVRDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTARLSWDID-SGQYIEGFYLYARE 680

Human   702 TSG-----LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEE 761
            ...     :...:..|.|.       |..:..|.|..|||..:.|::....|..|.|:.:||.|:
  Fly   681 LHSSEYKMVTLLNKGQGLS-------SCTVPGLAKASTYEFFLVPFYKSIVGKPSNSRRMRTLED 738

Human   762 APSAPPQSVTVLTVGSYNSTSISVSWDPPPPDH-QNGIIQEYKIWCLG----NETRFHINKTVDA 821
            .|.|||..:..:   .:|.||:.:.|.||.|:. :|||:..|.:...|    |.||...|.|:||
  Fly   739 VPEAPPYGMEAI---QFNRTSVFLKWLPPQPNRTRNGILTSYNVVVKGLDVHNTTRIFKNMTIDA 800

Human   822 AIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVIT-ENNNSITEQIT-DVVK 884
            |..::::..|..|:.|.:.|||:|..|||..|:|..:.|..|.:.:.| .....|:..|. |.:.
  Fly   801 AAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKPAVLRIDARTQSLDTGYTRYPISRDIADDFLT 865

Human   885 QPAFIAGIGG--ACWVILMGFSIWLYWRRKKRKGLS------NYAVTFQRGDGGLMSNGSRPGLL 941
            |..||..:|.  |..|.|:| ::.|:.|.:..|..|      |:|:...|....|..||.  |.:
  Fly   866 QTWFIVLLGSIIAIIVFLLG-ALVLFKRYQFIKQTSLGSLHGNHAIGTVRKFPTLPLNGG--GAV 927

Human   942 NAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDF 1006
            .||.                 :||.:.   .|..|.|..:.|..|...:.|...:.|.:.|.   
  Fly   928 GAGG-----------------SNSTAA---AGQSGHGLWIDPTSGVWRQAAGGGNPGGVGSC--- 969

Human  1007 TTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGN 1071
            |||.                              .||                 ||:.....:|.
  Fly   970 TTKE------------------------------QLP-----------------GYAQATAQQGQ 987

Human  1072 NALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSGS--LSGGKGG--------------- 1119
            ...| :|||   |.||   |.|.........|...|...|:  :.||.||               
  Fly   988 QPTL-LPDY---ERLS---PLNMPDYAEVACSTFKSPTHGAPPMGGGGGGQSASLYDSCGAYATT 1045

Human  1120 ------KKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLP 1178
                  |..:|:.::||.:::||...|                 |...:.|..|..|   .||  
  Fly  1046 NVVANVKLYQNRYATKPNQSSGSNNNN-----------------HQGNDYQSTGMYS---APP-- 1088

Human  1179 VQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQ-PMLQAHLDEL- 1241
               ..|.|..:..::...:.|.......|          |||.||.||.:..: .:.:..:|:| 
  Fly  1089 ---SAHYGCLEPKQQQQQQQPNLMTTSTA----------STAILTNSPAKVKKINITENKMDQLE 1140

Human  1242 ---TRAYQFDIAKQTWHIQSNNQPPQPPVPPLG-YVSGALISDLETDVADDDADDEEEALEIPRP 1302
               .|...|:..:|.  :.::|...|    .|| |.:..|.:.:.:.........:.:...:.:.
  Fly  1141 GKSERTNPFNQQQQL--LLASNALKQ----GLGAYANTTLAAQMASGGGAGTLRRQRQPKTLYKS 1199

Human  1303 LRALDQTPGSSMDNLDSSVTGSMVNG-----WGSASDEDRNF-------SSHRSSVGSSSDGSIF 1355
            ...:....|...:.:::|| |:..||     .|....|..:|       |:::.....:|..||.
  Fly  1200 ENNILGKSGLRQNTMNASV-GAPSNGQMDFLTGGPPSEGGDFSGLGLCNSTNQLLNDWASSASIA 1263

Human  1356 ASGSF--------AQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPRPTSPFSTDS--NTSAALS 1410
            |.|.:        .|.|...|.      |||....:..|:.|.:..:...||...|  ||.:..|
  Fly  1264 APGDYHFGSKQPSKQHLYVKAK------DGTWSAVSSDAYQSFKHQQQHHPFLAGSGDNTKSLAS 1322

Human  1411  1410
              Fly  1323  1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ROBO2XP_011532283.1 Ig1_Robo 53..152 CDD:143317 59/98 (60%)
Ig 160..244 CDD:325142 37/86 (43%)
Ig 265..333 CDD:325142 27/69 (39%)
Ig4_Robo 355..444 CDD:143203 32/93 (34%)
IG 451..532 CDD:214652 35/81 (43%)
FN3 549..642 CDD:238020 30/95 (32%)
FN3 673..758 CDD:238020 21/95 (22%)
FN3 766..859 CDD:238020 34/97 (35%)
PTN13_u3 <1374..>1431 CDD:318742 11/39 (28%)
robo3NP_608592.2 Ig 22..117 CDD:299845 59/98 (60%)
I-set 23..116 CDD:254352 58/96 (60%)
I-set 122..211 CDD:254352 39/89 (44%)
Ig 125..211 CDD:299845 37/86 (43%)
I-set 215..302 CDD:254352 34/86 (40%)
Ig 232..302 CDD:299845 27/69 (39%)
I-set 306..401 CDD:254352 32/96 (33%)
Ig 320..411 CDD:299845 32/93 (34%)
I-set 412..492 CDD:254352 36/80 (45%)
IGc2 429..489 CDD:197706 26/60 (43%)
FN3 519..612 CDD:238020 30/94 (32%)
FN3 644..735 CDD:238020 22/98 (22%)
fn3 743..832 CDD:278470 32/91 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6690
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.917438 Normalized mean entropy S5483
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm8568
orthoMCL 1 0.900 - - OOG6_101537
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.620

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