DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ROBO1 and robo1

DIOPT Version :10

Sequence 1:XP_011532278.1 Gene:ROBO1 / 6091 HGNCID:10249 Length:1654 Species:Homo sapiens
Sequence 2:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster


Alignment Length:1645 Identity:462/1645 - (28%)
Similarity:671/1645 - (40%) Gaps:434/1645 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
            |||:|||:||:|.|.||||||||.||:|.|||||:|.||.|.|  ::.:|||:....|:|||.|.
  Fly    56 PRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIEWFKDGEPVST--NEKKSHRVQFKDGALFFYRT 118

Human   133 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGH 197
            :.|:|.: |.|.|.|||:|.:|:|||.:|||::|:||||||..|.|..||.||.|::||.||:|.
  Fly   119 MQGKKEQ-DGGEYWCVAKNRVGQAVSRHASLQIAVLRDDFRVEPKDTRVAKGETALLECGPPKGI 182

Human   198 PEPTISWKKDGSPLDD-------KDERITI-RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 254
            ||||:.|.|||.||||       ...|:.| .||.|:|:.....|.|.|.|:..|:||.|||..|
  Fly   183 PEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYA 247

Human   255 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEI-RDDHTLKIR 318
            :|.|..:|.|:|.|.:..:....:|.|.|...|||.|.|.|:|::|.:|.||..| .|:.:|:|.
  Fly   248 KLIVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEIS 312

Human   319 KVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQP 383
            .:|..|.|:|.|.|.|.||:..|.|:|.|..   ||:|..:|.::.|.|...|...|.|:|||.|
  Fly   313 NITPTDEGTYVCEAHNNVGQISARASLIVHA---PPNFTKRPSNKKVGLNGVVQLPCMASGNPPP 374

Human   384 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 448
            ::||.:||...|:|   |..|..|..|:..|.|.||:|::.|.|||:|...:|..|...:.:|:|
  Fly   375 SVFWTKEGVSTLMF---PNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQV 436

Human   449 TDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 513
            :. :.:||||:|:.||.|||:.......|.|.|||:|.|.|.|..||..|.. .:|...::...|
  Fly   437 SS-LDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQA-GNRYSIIQGSSL 499

Human   514 QIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRN 578
            ::...:|.|:|.|||.||...||.:|:|.:.|::.| .....|..||:..|:.|..|:|.:|||.
  Fly   500 RVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPG-STSLHRAADPSTYPAPPGTPKVLNVSRT 563

Human   579 TVTLSWQPNLNS-GATP--TSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 640
            :::|.|..:... ||..  ..|.:|.||....:.|...|:.|......|.||.|...|:|||||.
  Fly   564 SISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVRAE 628

Human   641 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQREL--GNAVLHLHNPTVLSSSSIEVHWT--VD 701
            |..|||.||.:|:.:||.:....:...:.....|.|  |.:| .|.:.:.:::|::.:.|.  |.
  Fly   629 NTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGKSV-ELIDASAINASAVRLEWMLHVS 692

Human   702 QQSQYIQGYKILYR----PSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 762
            ...:|::|.:|.|:    ||...|.      ..|...:..|.|:.:|:|...||....|||...:
  Fly   693 ADEKYVEGLRIHYKDASVPSAQYHS------ITVMDASAESFVVGNLKKYTKYEFFLTPFFETIE 751

Human   763 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WCLGNETR 826
            |..|..|.|.|.|:.|||||..:.:...  |.||..|.|.|||....||.:..||: ...||..:
  Fly   752 GQPSNSKTALTYEDVPSAPPDNIQIGMY--NQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMK 814

Human   827 YHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLD---------AH----- 877
            ...|.|::.:|.||::..|..|..|||.:.:.|.||.|..|:|..:.:|         ||     
  Fly   815 VLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTH 879

Human   878 --------------GNPVSPED-QVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWL------ 921
                          || :.|.| ..:..::.:|.:..|          |::::|..:.|      
  Fly   880 DGRHEGQDLTYHNNGN-IPPGDINPTTHKKTTDYLSGP----------WLMVLVCIVLLVLVISA 933

Human   922 -----YRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLAD 981
                 |..||.:                     :|.:.|..:|.|......|||:...:. |:  
  Fly   934 AISMVYFKRKHQ---------------------MTKELGHLSVVSDNEITALNINSKESL-WI-- 974

Human   982 TWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDL 1046
                  ::|.....:.....:|.|:|.|.::...:.  :||||.          ...|.|.:||.
  Fly   975 ------DHHRGWRTADTDKDSGLSESKLLSHVNSSQ--SNYNNS----------DGGTDYAEVDT 1021

Human  1047 SNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQE 1111
            .|.........||:           .|||||||.:|.::.|......:..|.:|           
  Fly  1022 RNLTTFYNCRKSPD-----------NPTPYATTMIIGTSSSETCTKTTSISADK----------- 1064

Human  1112 VAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPK 1176
                                              |..|...|:.:..|             :.|.
  Fly  1065 ----------------------------------DSGTHSPYSDAFAG-------------QVPA 1082

Human  1177 VPKQGG---------MNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDE 1232
            ||....         :||::.|||||.||||.|.         ..|.|..|              
  Fly  1083 VPVVKSNYLQYPVEPINWSEFLPPPPEHPPPSST---------YGYAQGSP-------------- 1124

Human  1233 LEEEEDERGPTPPVRGAASSPAAVSYS-HQST----ATLTPSPQEELQPMLQDCPEETGHMQHQP 1292
               |...:.......|.:::.:.::.| |.|:    :....|||..:.     ||.|  ::...|
  Fly  1125 ---ESSRKSSKSAGSGISTNQSILNASIHSSSSGGFSAWGVSPQYAVA-----CPPE--NVYSNP 1179

Human  1293 --------DRRRQ--PVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTR 1347
                    ..|.|  |.:..||..|     .|...:||                           
  Fly  1180 LSAVAGGTQNRYQITPTNQHPPQLP-----AYFATTGP--------------------------- 1212

Human  1348 RLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAA 1412
                                          |.|...:::                  .||....|
  Fly  1213 ------------------------------GGAVPPNHL------------------PFATQRHA 1229

Human  1413 AAEY-AGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRR 1476
            |:|| |||..||                |.:..:..|.|:..:.:.||                 
  Fly  1230 ASEYQAGLNAAR----------------CAQSRACNSCDALATPSPMQ----------------- 1261

Human  1477 ETYTDDLPPPPVP-PPAIKSPTAQSKTQLEVRPVVVPKLPSMDAR-----TDRSSDRKGSSYKGR 1535
                   |||||| |.....|         |.|...|..|:....     :...||...||...:
  Fly  1262 -------PPPPVPVPEGWYQP---------VHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQSHK 1310

Human  1536 EVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN- 1599
            ..|                :.:|..:..|.||....:|              .|..:|...:.| 
  Fly  1311 RQL----------------QLEEHGSSAKQRGGHHRRR--------------APVVQPCMESENE 1345

Human  1600 ------NPRDPSSSSSMSSR 1613
                  ..|..:|....|||
  Fly  1346 NMLAEYEQRQYTSDCCNSSR 1365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ROBO1XP_011532278.1 IgC_1_Robo 68..166 CDD:409490 55/97 (57%)
Ig strand A 68..72 CDD:409490 3/3 (100%)
Ig strand A' 75..80 CDD:409490 2/4 (50%)
Ig strand B 84..92 CDD:409490 7/7 (100%)
Ig strand C 98..103 CDD:409490 4/4 (100%)
Ig strand C' 106..108 CDD:409490 1/1 (100%)
Ig strand D 119..122 CDD:409490 1/2 (50%)
Ig strand E 125..131 CDD:409490 4/5 (80%)
Ig strand F 143..151 CDD:409490 5/7 (71%)
Ig strand G 154..166 CDD:409490 7/11 (64%)
IgI_2_Robo 173..258 CDD:409389 43/92 (47%)
Ig strand A 173..176 CDD:409389 1/2 (50%)
Ig strand A' 178..182 CDD:409389 1/3 (33%)
Ig strand B 186..193 CDD:409389 3/6 (50%)
Ig strand C 201..206 CDD:409389 2/4 (50%)
Ig strand C' 208..211 CDD:409389 1/2 (50%)
Ig strand D 217..221 CDD:409389 2/4 (50%)
Ig strand E 223..229 CDD:409389 3/5 (60%)
Ig strand F 236..244 CDD:409389 3/7 (43%)
Ig strand G 247..258 CDD:409389 6/10 (60%)
IgI_3_Robo 265..347 CDD:409390 32/82 (39%)
Ig strand A 265..268 CDD:409390 1/2 (50%)
Ig strand A' 270..274 CDD:409390 0/3 (0%)
Ig strand B 277..286 CDD:409390 3/8 (38%)
Ig strand C 292..297 CDD:409390 2/4 (50%)
Ig strand C' 300..303 CDD:409390 1/2 (50%)
Ig strand D 306..311 CDD:409390 2/5 (40%)
Ig strand E 312..319 CDD:409390 2/6 (33%)
Ig strand F 326..334 CDD:409390 4/7 (57%)
Ig strand G 337..347 CDD:409390 4/9 (44%)
IgI_4_Robo 355..452 CDD:409391 35/96 (36%)
Ig strand A 355..359 CDD:409391 1/3 (33%)
Ig strand A' 361..365 CDD:409391 0/3 (0%)
Ig strand B 371..379 CDD:409391 3/7 (43%)
Ig strand C 382..389 CDD:409391 3/6 (50%)
Ig strand C' 391..394 CDD:409391 1/2 (50%)
Ig strand D 407..412 CDD:409391 2/4 (50%)
Ig strand E 414..421 CDD:409391 4/6 (67%)
Ig strand F 427..436 CDD:409391 4/8 (50%)
FN3 428..882 CDD:442628 156/493 (32%)
Ig strand G 438..449 CDD:409391 2/10 (20%)
IgI_5_Robo 459..545 CDD:409544 32/85 (38%)
Ig strand A 459..462 CDD:409544 1/2 (50%)
Ig strand A' 466..469 CDD:409544 2/2 (100%)
Ig strand B 475..482 CDD:409544 2/6 (33%)
Ig strand C 488..493 CDD:409544 2/4 (50%)
Ig strand C' 495..497 CDD:409544 1/1 (100%)
Ig strand D 504..508 CDD:409544 1/3 (33%)
Ig strand E 511..516 CDD:409544 1/4 (25%)
Ig strand F 524..532 CDD:409544 5/7 (71%)
Ig strand G 535..545 CDD:409544 4/9 (44%)
FN3 564..650 CDD:238020 33/88 (38%)
robo1NP_476899.1 Ig 56..151 CDD:472250 55/97 (57%)
Ig strand B 73..77 CDD:409353 3/3 (100%)
Ig strand C 86..90 CDD:409353 3/3 (100%)
Ig strand E 111..115 CDD:409353 2/3 (67%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
IgI_2_Robo 158..251 CDD:409389 43/92 (47%)
Ig strand A 158..161 CDD:409389 1/2 (50%)
Ig strand A' 163..167 CDD:409389 1/3 (33%)
Ig strand B 171..178 CDD:409389 3/6 (50%)
Ig strand C 186..191 CDD:409389 2/4 (50%)
Ig strand C' 193..196 CDD:409389 1/2 (50%)
Ig strand D 209..213 CDD:409389 1/3 (33%)
Ig strand E 216..222 CDD:409389 3/5 (60%)
Ig strand F 229..237 CDD:409389 3/7 (43%)
Ig strand G 240..251 CDD:409389 6/10 (60%)
IgI_3_Robo 258..341 CDD:409390 32/82 (39%)
Ig strand A 258..261 CDD:409390 1/2 (50%)
Ig strand A' 263..267 CDD:409390 0/3 (0%)
Ig strand B 270..279 CDD:409390 3/8 (38%)
Ig strand C 285..290 CDD:409390 2/4 (50%)
Ig strand C' 293..296 CDD:409390 1/2 (50%)
Ig strand D 299..304 CDD:409390 2/4 (50%)
Ig strand E 305..313 CDD:409390 3/7 (43%)
Ig strand F 320..328 CDD:409390 4/7 (57%)
Ig strand G 331..341 CDD:409390 4/9 (44%)
Ig 346..437 CDD:472250 34/93 (37%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 1/3 (33%)
Ig strand E 402..406 CDD:409353 2/3 (67%)
Ig strand F 416..421 CDD:409353 3/4 (75%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 32/85 (38%)
Ig strand B 462..466 CDD:409544 1/3 (33%)
Ig strand C 475..479 CDD:409544 1/3 (33%)
Ig strand E 497..501 CDD:409544 1/3 (33%)
FN3 507..>916 CDD:442628 127/419 (30%)
Ig strand F 511..516 CDD:409544 3/4 (75%)
Ig strand G 524..527 CDD:409544 1/2 (50%)
FN3 549..637 CDD:238020 32/87 (37%)
fn3 770..855 CDD:394996 30/86 (35%)

Return to query results.
Submit another query.