DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ROBO1 and robo1

DIOPT Version :9

Sequence 1:	XP_011532278.1	Gene:	ROBO1 / 6091	HGNCID:	10249	Length:	1654	Species:	Homo sapiens
Sequence 2:	XP_012811710.3	Gene:	robo1 / 100124716	XenbaseID:	XB-GENE-948809	Length:	1680	Species:	Xenopus tropicalis

Alignment Length:	1665	Identity:	1400/1665 - (84%)
Similarity:	1509/1665 - (90%)	Gaps:	23/1665 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     3 WKHVPFLVMISLLSLSPNHLFLAQLI---PDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQE 64
            |..:.|    ||.:::|:    |.||   .|.:|::||.|.||.:||||:|||||.|||||||||
Frog    26 WNKIAF----SLATVTPS----AALIYFSTDSDDLDRGLDSGTALPTSDHDDNSLVYTGSRLRQE 82

Human    65 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 129
            |||||||||||||||||||||||||||||||||||||||||::||||||||||||||||||||||
Frog    83 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGDKVETDKDDPRSHRMLLPSGSLFF 147

Human   130 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 194
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   148 LRIVHGRKIRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 212

Human   195 RGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 258
            ||||||||||||||:|: |||||||||||||||||||||||||||||||||||||||||||||||
Frog   213 RGHPEPTISWKKDGTPIDDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 277

Human   259 LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAG 323
            |||||||:||||:|||||||.|||||||||||||||||||||:||||||||||||||||||||||
Frog   278 LERPSFVRRPSNMAVTVDDSVEFKCEARGDPVPTVRWRKDDGDLPKSRYEIRDDHTLKIRKVTAG 342

Human   324 DMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 388
            ||||||||||||||||||||.|||||.||||:||||||||||||||||||||||||||||||||:
Frog   343 DMGSYTCVAENMVGKAEASAVLTVQVVSEPPNFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWQ 407

Human   389 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 453
            :||||||||||||||||||||||||||||||.||:|||||||||||||||||.|||:||||||:|
Frog   408 KEGSQNLLFSYQPPQSSSRFSVSQTGDLTITTVQKSDVGYYICQTLNVAGSITTKAFLEVTDVVA 472

Human   454 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYA 518
            |||||||||||||||||||||.:::|:|:|.|||||.|||||:|:.||||||||.::|.||||||
Frog   473 DRPPPVIRQGPVNQTVAVDGTLIMNCIASGIPVPTIHWRKDGILIPTQDSRIKQQDSGALQIRYA 537

Human   519 KLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 583
            ||.|||||||.|||.||||.||||||||||||||||||.|||||||||||||||||||:||||||
Frog   538 KLSDTGRYTCTASTTSGEANWSAYIEVQEFGVPVQPPRATDPNLIPSAPSKPEVTDVSKNTVTLS 602

Human   584 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 648
            ||||||||||||||:|||||||||||||||||||||::.|:|.|||||||||||||.||||:|||
Frog   603 WQPNLNSGATPTSYLIEAFSHASGSSWQTVAENVKTDSFAVKALKPNAIYLFLVRAVNAYGLSDP 667

Human   649 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKIL 713
            |||||||||||:.||||||||||||||||:.||||||||:|||||||||||||||||||||||||
Frog   668 SQISDPVKTQDIPPTSQGVDHKQVQRELGDVVLHLHNPTILSSSSIEVHWTVDQQSQYIQGYKIL 732

Human   714 YRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 778
            ||||..|.|||.|.:||||||||||.|||:||||||||||||||||||||||||::||||:||||
Frog   733 YRPSAENRGESAWSIFEVRTPAKNSAVIPELRKGVNYEIKARPFFNEFQGADSEVRFAKTMEEAP 797

Human   779 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 843
            |||||.|||:|||||||||:|:||||||||||||||||||||||||:||||||||||||.|||||
Frog   798 SAPPQSVTVTKNDGNGTAIVVAWQPPPEDTQNGMVQEYKVWCLGNESRYHINKTVDGSTLSVVIP 862

Human   844 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGA 908
            .|||||:|||||||||||||||||||.:||||:.||||.|.||||||||||||||||||||||||
Frog   863 SLVPGIKYSVEVAASTGAGSGVKSEPNYIQLDSFGNPVPPGDQVSLAQQISDVVKQPAFIAGIGA 927

Human   909 ACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEP 973
            |||||||||||||||||||||||||:||||||||||||||||.||||||||||.||||||||||.
Frog   928 ACWIILMVFSIWLYRHRKKRNGLTSSYAGIRKVPSFTFTPTVAYQRGGEAVSSAGRPGLLNISET 992

Human   974 AAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPES 1038
            |.||||||||||||||||:|.|:|||:|||||||||.|||||||||||||||||:||||||:|:|
Frog   993 ANQPWLADTWPNTGNNHNECPINCCTSGNGNSDSNLATYSRPADCIANYNNQLDSKQTNLMVPDS 1057

Human  1039 TVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK 1103
            .||||||||||||||||||||||||||||||:|||||||||||||||:|||:|..:||..|||||
Frog  1058 AVYGDVDLSNKINEMKTFNSPNLKDGRFVNPAGQPTPYATTQLIQSNISNNINTSAGDVDEKHWK 1122

Human  1104 PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGH 1168
            |..|||.:|.|:||||:||||:||||||:||:|.|||||||:|||.|||||||||||||||||||
Frog  1123 PPCQQKPDVTPMQYNIMEQNKINKDYRASDTIPSTIPYNQSHDQNAGGSYNSSDRGSSTSGSQGH 1187

Human  1169 KKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDEL 1233
            ||..|||||.||.||||||||||||||||||..:|:|.:|.|||||:|:|||:||.|||||||||
Frog  1188 KKSTRTPKVSKQAGMNWADLLPPPPAHPPPHGATEDYTLSADESYDRELPCPIPPTRMYLQQDEL 1252

Human  1234 EEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQP 1298
             |||||||||||:|||||||||||||||||||||||||:||||||||||||.||.|||.:|||..
Frog  1253 -EEEDERGPTPPIRGAASSPAAVSYSHQSTATLTPSPQDELQPMLQDCPEEIGHTQHQLERRRHQ 1316

Human  1299 VSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVG 1363
            :|||||||||||||||||||||:|||||||.||||.|:.::||.|||:|||||||||||||||||
Frog  1317 ISPPPPPRPISPPHTYGYISGPIVSDMDTDVPEEEGDDGEIEVTKMQSRRLLLRGLEQTPASSVG 1381

Human  1364 DLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD 1428
            ||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||.|||:
Frog  1382 DLESSVTGSMINGWGSASEEDNVSSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARHQMQE 1446

Human  1429 AA--------GRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPP 1485
            ||        |||.||||.|||||||||||||||.||:||:|||||.|||.||||::.|||||||
Frog  1447 AAGVSRLCLPGRRPFHASHCPRPTSPVSTDSNMSTAVIQKSRPAKKQKHQQGHLRKDVYTDDLPP 1511

Human  1486 PPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQV-VDMRTN 1549
            ||:|||||||||..||.|||.||.:..|....:.|.:|..:|||.||:|||..|.||. .:.|||
Frog  1512 PPLPPPAIKSPTGPSKAQLEGRPGLSQKYLVAEQRLERPGERKGVSYRGREGPDSRQQHAEARTN 1576

Human  1550 PGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRG 1614
            .|:.||:.|||.|||.|..||:|.|..|...:.|||||||||:||||||||||||||||||||||
Frog  1577 SGERRESSEQQLDGKMRKGKASKWDGAPIVANQIQEDILPYCKPTFPTSNNPRDPSSSSSMSSRG 1641

Human  1615 SGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1654
            ||.|:|.:...||||.||||:||.||||.| .:|:|||||
Frog  1642 SGGRRRGEQTTGRRNAAEMQLLGNYERGVD-EDEIEETES 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ROBO1	XP_011532278.1	Ig1_Robo	67..166	CDD:143317	95/98 (97%)
		I-set	68..165	CDD:254352	93/96 (97%)
		I-set	172..258	CDD:254352	83/86 (97%)
		Ig2_Robo	174..258	CDD:143201	81/84 (96%)
		I-set	262..347	CDD:254352	79/84 (94%)
		Ig3_Robo	279..347	CDD:143202	64/67 (96%)
		I-set	354..448	CDD:254352	86/93 (92%)
		Ig4_Robo	368..457	CDD:143203	81/88 (92%)
		I-set	458..545	CDD:254352	67/86 (78%)
		Ig	462..536	CDD:299845	55/73 (75%)
		FN3	564..650	CDD:238020	76/85 (89%)
		FN3	687..773	CDD:238020	74/85 (87%)
		fn3	781..867	CDD:278470	77/85 (91%)
robo1	XP_012811710.3	IgC_1_Robo	86..184	CDD:409490	94/97 (97%)
		Ig strand B	103..107	CDD:409490	3/3 (100%)
		Ig strand C	116..120	CDD:409490	3/3 (100%)
		Ig strand E	143..147	CDD:409490	3/3 (100%)
		Ig strand F	162..167	CDD:409490	4/4 (100%)
		Ig strand G	176..179	CDD:409490	2/2 (100%)
		IgI_2_Robo	191..277	CDD:409389	82/85 (96%)
		Ig strand B	205..209	CDD:409389	3/3 (100%)
		Ig strand C	219..223	CDD:409389	3/3 (100%)
		Ig strand E	242..246	CDD:409389	3/3 (100%)
		Ig strand F	256..261	CDD:409389	4/4 (100%)
		Ig strand G	270..273	CDD:409389	2/2 (100%)
		IgI_3_Robo	284..366	CDD:409390	76/81 (94%)
		Ig strand B	298..302	CDD:409390	2/3 (67%)
		Ig strand C	311..315	CDD:409390	3/3 (100%)
		Ig strand E	332..336	CDD:409390	3/3 (100%)
		Ig strand F	346..351	CDD:409390	4/4 (100%)
		Ig strand G	359..362	CDD:409390	2/2 (100%)
		IgI_4_Robo	374..471	CDD:409391	89/96 (93%)
		Ig strand B	390..394	CDD:409391	3/3 (100%)
		Ig strand C	403..407	CDD:409391	3/3 (100%)
		Ig strand E	433..437	CDD:409391	3/3 (100%)
		Ig strand F	447..452	CDD:409391	4/4 (100%)
		Ig strand G	460..463	CDD:409391	1/2 (50%)
		IgI_5_Robo	478..564	CDD:409544	66/85 (78%)
		Ig strand B	494..498	CDD:409544	0/3 (0%)
		Ig strand C	507..511	CDD:409544	2/3 (67%)
		Ig strand E	530..534	CDD:409544	2/3 (67%)
		Ig strand F	544..549	CDD:409544	4/4 (100%)
		Ig strand G	557..560	CDD:409544	1/2 (50%)
		FN3	583..669	CDD:238020	76/85 (89%)
		FN3	706..792	CDD:238020	74/85 (87%)
		fn3	800..886	CDD:394996	77/85 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1304	1.000	Domainoid score	I331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2206
Inparanoid	1	1.050	2868	1.000	Inparanoid score	I274
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17856at32523
OrthoFinder	1	1.000	-	-		FOG0000772
OrthoInspector	1	1.000	-	-		oto158535
Panther	1	1.100	-	-	LDO	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X493
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.160