DRSC/TRiP Functional Genomics Resources

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Protein Alignment BCL9 and lgs

DIOPT Version :10

Sequence 1:NP_004317.2 Gene:BCL9 / 607 HGNCID:1008 Length:1426 Species:Homo sapiens
Sequence 2:NP_651922.1 Gene:lgs / 43791 FlyBaseID:FBgn0039907 Length:1469 Species:Drosophila melanogaster


Alignment Length:1438 Identity:301/1438 - (20%)
Similarity:466/1438 - (32%) Gaps:484/1438 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     2 HSSNPKVRSSPSGNTQ------SSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ 60
            ||::..| |:..|.||      .|.|:|..|......:.|        :|...|...||..:.|.
  Fly   123 HSNSSNV-SATVGLTQMVDCDEQSKKNKCSVKDEEAEISS--------NKAKGQAAGGGCETGST 178

Human    61 PS------PCD----------SKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFD 109
            .|      |.|          .:...|:|...|...||:|  |...|.|. ..|.|| ||.||..
  Fly   179 SSLTVKEEPTDVLGSLVNMKKEERENHSPTMSPVGFGSIG--NAQDNSAT-PVKIER-ISNDSTT 239

Human   110 QRDPGT---PNDDSDIKECNSADHIKSQDSQHTP-------HSMTP----------SNATAPRSS 154
            ::...:   .||:..::.||..:.....:|.:.|       ..:.|          .|.....::
  Fly   240 EKKGSSLTMNNDEMSMEGCNQLNPDFINESLNNPAISSILVSGVGPIPGIGVGAGTGNLLTANAN 304

Human   155 TPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFH--------------I 205
            ..|.|.:...:....|..    ::||||::|||.||:||.||.:||:::|              :
  Fly   305 GISSGSSNCLDYMQQQNH----IFVFSTQLANKGAESVLSGQFQTIIAYHCTQPATKSFLEDFFM 365

Human   206 QN-ISNNKTERSTA---PLNTQISALRNDPKPL----PQQPPAPA--------NQDQNSSQNTRL 254
            :| :..||.:|..:   |...........|.|:    .|||....        ||.:||.::|..
  Fly   366 KNPLKINKLQRHNSVGMPWIGMGQVGLTPPNPVAKITQQQPHTKTVGLLKPQFNQHENSKRSTVS 430

Human   255 QPTPPIPAPAPKPAAPPRPLDRESP-GVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVS 318
            .|:...             :|:..| |.|.:|:...|..::::     .:|.||..:..:::..|
  Fly   431 APSNSF-------------VDQSDPMGNETELMCWEGGSSNTS-----RSGQNSRNHVDSISTSS 477

Human   319 QGSNSSSADPKAPPPPPVSSGEPPTL-GEN----------PD-GLSQEQLEHRERSLQTLRDIQR 371
            :.......:........|:.|..|.| .||          || .|:.:|.:|||..|..::.:.:
  Fly   478 ESQAIKILEAAGVDLGQVTKGSDPGLTTENNIVSLQGVKVPDENLTPQQRQHREEQLAKIKKMNQ 542

Human   372 MLFPDEKEFTGAQ-------------------SGGPQQNP------------------------- 392
            .|||:.:...||.                   .||...||                         
  Fly   543 FLFPENENSVGANVSSQITKIPGDLMMGMSGGGGGSIINPTMRQLHMPGNAKSELLSATSSGLSE 607

Human   393 ------------GVLDGPQKKPEGPIQA------------------MMAQSQSLGKG--PGPRTD 425
                        |.:.|.....:..:|.                  |...|.....|  .|..||
  Fly   608 DVMHPGDVISDMGAVIGCNNNQKTSVQCGSGVGVVTGTTAAGVNVNMHCSSSGAPNGNMMGSSTD 672

Human   426 VGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRR--KQE 488
            :.|.||......:..:|| |....:|..|.|    |.......|:.|.|:|.:|:||:.:  |..
  Fly   673 MLASFGNTSCNVIGTAPD-MSKEVLNQDSRT----HSHQGGVAQMEWSKIQHQFFEERLKGGKPR 732

Human   489 QV---VVQQCSLQDMMVHQHGPRG-----------VVRGPPPPYQMTPSEGWAPGGTEPFSDGIN 539
            ||   ||.|         |..|.|           .::||||||.........|..|:  |...:
  Fly   733 QVTGTVVPQ---------QQTPSGSGGNSLNNQVRPLQGPPPPYHSIQRSASVPIATQ--SPNPS 786

Human   540 MPH--SLP-PRGMAPHPNMPGSQMRLPGFAGMINS--------------------------EMEG 575
            .|:  ||| ||..|....:|.:...:.|...:..|                          :...
  Fly   787 SPNNLSLPSPRTTAAVMGLPTNSPSMDGTGSLSGSVPQANTSTVQAGTTTVLSANKNCFQADTPS 851

Human   576 PNVPNPASRPGLSGVSWPD--DVPKIPDGRNFPP-----GQGIFSGPGRGERFPNPQG------- 626
            |:..|.:...|.|.|...:  ..|..|.....|.     ||. .:|.....|.|:|||       
  Fly   852 PSNQNRSRNTGSSSVLTHNLSSNPSTPLSHLSPKEFESFGQS-SAGDNMKSRRPSPQGQRSPVNS 915

Human   627 LSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQR-HME-----PGNNPIFPRIPVEGP 685
            |.|.....:.|....|..|...|:. ..:..:|....||.. .||     .|.:..|.|.....|
  Fly   916 LIEANKDVRFAASSPGFNPHPHMQS-NSNSALNAYKMGSTNIQMERQASAQGGSVQFSRRSDNIP 979

Human   686 LSPSRGDFPKGIPP--------------QM------------------------GPGR---ELEF 709
            |:|:.|:.|   ||              ||                        |||.   .:|.
  Fly   980 LNPNSGNRP---PPNKMTQNFDPISSLAQMSQQLTSCVSSMGSPAGTGGMTMMGGPGPSDINIEH 1041

Human   710 GMVPSGMKGD----VNLN----VNMGSNS---QMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQK 763
            |:: ||:.|.    :|.|    :|:..||   :|:..||..|| ||.                  
  Fly  1042 GII-SGLDGSGIDTINQNNCHSMNVVMNSMGPRMLNPKMCVAG-GPN------------------ 1086

Human   764 MVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLR--------------NLREPIGPDQRTNSRL 814
                            ||..|.|.|    .|.|||              |.:..:.|..|...|:
  Fly  1087 ----------------GPPGFNPNS----PNGGLRENSIGSGCGSANSSNFQGVVPPGARMMGRM 1131

Human   815 SHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPT----MHQVQSPM 875
                |:....:.|| ::.........:...|:....|.:. ::.|.|.::.|.    :.:..:|.
  Fly  1132 ----PVNFGSNFNP-NIQVKASTPNTIQYMPVRAQNANNN-NNNGANNVRMPPSLEFLQRYANPQ 1190

Human   876 LGS---------PSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP 931
            :|:         ||.:..:|..|    |::|||.|..      :|.:::......|..:.|..|.
  Fly  1191 MGAVGNGSPICPPSASDGTPGMP----GLMAGPGAGG------MLMNSSGEQHQNKITNNPGASN 1245

Human   932 G----WTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTP 992
            |    ...:....:...|..|.|...:.:..|:|:..:.      |.|.:|   |:.|:      
  Fly  1246 GINFFQNCNQMSIVDEEGGLPGHDGSMNIGQPSMIRGMR------PHAMRP---NVMGA------ 1295

Human   993 YTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTV---------ASSDDDSP-------P 1041
             .|||            ::|..:||..|      |.|..|         ||.:...|       .
  Fly  1296 -RMPP------------VNRQIQFAQSS------DGIDCVGDPSSFFTNASCNSAGPHMFGSAQQ 1341

Human  1042 ARSP------NLPS--MNNMPGMGINTQNPRISGPNPVVPMPTLSP-----MGMTQPLSHSNQMP 1093
            |..|      |:||  ..|..|:.:.....::.|.........:.|     |.....:|.:|.:.
  Fly  1342 ANQPKTQHIKNIPSGMCQNQSGLAVAQGQIQLHGQGHAQGQSLIGPTNNNLMSTAGSVSATNGVS 1406

Human  1094 SPNAVGPN 1101
            ..|.|||:
  Fly  1407 GINFVGPS 1414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BCL9NP_004317.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..173 47/212 (22%)
Interaction with PYGO1 177..205 16/41 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..439 61/336 (18%)
BCL9 350..386 CDD:431912 11/54 (20%)
Interaction with CTNNB1. /evidence=ECO:0000269|PubMed:17052462 358..374 4/15 (27%)
PHA03247 <571..1186 CDD:223021 136/689 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..625 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..895 23/134 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..1002 18/95 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1052 9/43 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1152..1203
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1253..1275
lgsNP_651922.1 BCL9 521..557 CDD:431912 11/35 (31%)
ROM1 764..>995 CDD:227709 54/237 (23%)
Blue background indicates that the domain is not in the aligned region.

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