DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CELF5 and RIE1

DIOPT Version :9

Sequence 1:	NP_068757.2	Gene:	CELF5 / 60680	HGNCID:	14058	Length:	485	Species:	Homo sapiens
Sequence 2:	NP_011766.3	Gene:	RIE1 / 853165	SGDID:	S000003482	Length:	781	Species:	Saccharomyces cerevisiae

Alignment Length:	518	Identity:	101/518 - (19%)
Similarity:	168/518 - (32%)	Gaps:	187/518 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    47 LFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTY--------CARD---SAI 100
            :|||.|.:.|...:|..||.::|.|..:.::.|...|...|..|::|        |.::   ..:
Yeast   197 IFVGGIAKSLSIGELSFLFSKYGPILSMKLIYDKTKGEPNGYGFISYPLGSQASLCIKELNGRTV 261

Human   101 KAQTAL---HEQKTLPGMARPIQVKPADSESRGGRDRKLFVGML---NKQQSE------------ 147
            ...|..   |.::..........||..:::.   ..|.||:|.|   |.::.|
Yeast   262 NGSTLFINYHVERKERERIHWDHVKENNNDD---NFRCLFIGNLPYHNPEKVETLITPKEVIEVI 323

Human   148 -EDVLRLFQPFGVI-----------DECTVLRGPDGS-------------------SKGCAFVKF 181
             :::.:.|..|.:|           ...:|....:||                   .||..|:|.
Yeast   324 KKELSKKFPDFDIISYYFPKRSNTRSSSSVSFNEEGSVESNKSSNNTNGNAQDEDMLKGYGFIKL 388

Human   182 SSHTEAQAAIHAL-----HGSQTMPGASSSLVVKFA----------DTDKERTLRRMQQMVGQLG 231
            .:|.:|.|||...     ||::        |||..|          ..|:..::.....|.
Yeast   389 INHEQALAAIETFNGFMWHGNR--------LVVNKAVQHKVYNNHNSHDRHPSISNHNDME---- 441

Human   232 ILTPSLTLPFSPYSAYAQALMQQQTTVLSTSGSYL----SPGVAFSPCHIQQIGAVSLNGLPATP 292
             :......|...|:.|             |...|.    ..|.:....:::...:|.     :||
Yeast   442 -VLEFANNPMYDYNNY-------------TYDRYYFNNNKNGNSNDTSNVRYFDSVR-----STP 487

Human   293 IAPASGLHSPPLLGTTAVPGLVAPITNGFAGVVPFPGGHPALETVYANGLVPYPAQSPTVAETLH 357
            :|....|.                              :|..|: ::.|      :...|
Yeast   488 VAEKMDLF------------------------------YPQRES-FSEG------RGQRV----- 510

Human   358 PAFSGVQQYTAMYPTAAITPIAHSVPQPPPLLQQQQREGPEGCNLFIYHLPQEFGDTELTQMFLP 422
            |.|.|.:.....||:.       |...|.|:..||:      .||::.|:|..:.|.:|...:..
Yeast   511 PRFMGNKFDMYQYPST-------SYSLPIPMSNQQE------SNLYVKHIPLSWTDEDLYDFYKS 562

Human   423 FGNIISSKVFM-------------------DRATNQSKCFGFVSFDNPASAQAAIQAMNGFQI 466
            ||.|||.||..                   |.....|:.:|||||::|..|..||...:|:|:
Yeast   563 FGEIISVKVITVGGSKNKYRQQSNDSSSDNDLPVGSSRGYGFVSFESPLDAAKAILNTDGYQV 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CELF5	NP_068757.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		RRM1_CELF3_4_5_6	40..126	CDD:410041	20/92 (22%)
		half-pint	46..>372	CDD:130706	69/403 (17%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	28/140 (20%)
		RRM3_CELF3_4_5_6	396..474	CDD:241083	26/90 (29%)
RIE1	NP_011766.3	PABP-1234	195..757	CDD:130689	101/518 (19%)
RIE1	NP_011766.3	RRM3_CELF1-6	542..634	CDD:409797	25/84 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900