DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CELF5 and celf5a

DIOPT Version :9

Sequence 1:	NP_068757.2	Gene:	CELF5 / 60680	HGNCID:	14058	Length:	485	Species:	Homo sapiens
Sequence 2:	XP_021325030.1	Gene:	celf5a / 568052	ZFINID:	ZDB-GENE-050208-746	Length:	552	Species:	Danio rerio

Alignment Length:	556	Identity:	363/556 - (65%)
Similarity:	407/556 - (73%)	Gaps:	75/556 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     1 MARLTESEARRQQQQLLQPRPSPVGSS----------------------------GPEPPGG--- 34
            |||.|::|.||:|..  || |.|..||                            .|:|..|
Zfish     1 MARFTQTETRREQHP--QP-PHPAYSSLLFTGPGAAPTQHPLLLIPHQHQYAQIPFPKPMNGSES 62

Human    35 ---QPDG--MKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTYC 94
               .|:.  |||.||||||:|||||:|:||||||||||||:|:|||||||.||||||||||||||
Zfish    63 ISIHPENGTMKDQDAIKLFIGQIPRNLEEKDLKPLFEQFGKIHELTVLKDRYTGMHKGCAFLTYC 127

Human    95 ARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGV 159
            ||:||||||.|||||||||||.||||||||||||| |.|||||||||||||:||||.|||:|:||
Zfish   128 ARESAIKAQNALHEQKTLPGMTRPIQVKPADSESR-GEDRKLFVGMLNKQQTEEDVYRLFEPYGV 191

Human   160 IDECTVLRGPDGSSKGCAFVKFSSHTEAQAAIHALHGSQTMP---------GASSSLVVKFADTD 215
            |:||||||||||:||||||||||:|.|||:||.|||||||||         ||||||||||||||
Zfish   192 IEECTVLRGPDGNSKGCAFVKFSTHAEAQSAISALHGSQTMPTGSDSLLPQGASSSLVVKFADTD 256

Human   216 KERTLRRMQQMVGQLGILTPSLTLPFSPYSAYAQALMQQQTTVLSTS-GSYLSPGVAFSPCHIQQ 279
            ||||:|||||||||.||..|::.||||.||.||.||||||..:::.| |.||:|.|||....|.|
Zfish   257 KERTIRRMQQMVGQFGIFNPAIALPFSTYSTYAHALMQQQAALMAASHGGYLAPSVAFPTTQIHQ 321

Human   280 IGAVSLNGLPATPIAPAS--------GLHSPPL-LGTTAVPGLVAPITNGFAGVVPFPGGHPALE 335
            :||:::|.||.||:.|.|        ||.|||. :.|:|||.:|.||.|||..:...|.||||:|
Zfish   322 MGALNINSLPPTPMTPVSGEFHQTLAGLSSPPANITTSAVPSIVTPIVNGFTSIPHQPNGHPAVE 386

Human   336 TVYANGLVPYPAQSPTVAETLHPAFSGVQQYT-------------AMYPTAAITPIAHSVPQPPP 387
            .||.|||.||..||||.|:||..||:||||||             .:||...:|||..|:||||.
Zfish   387 AVYTNGLPPYSTQSPTAADTLQQAFTGVQQYTDLSDIREHPLYLYTIYPATTLTPIGQSLPQPPQ 451

Human   388 LLQQQQR---EGPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFD 449
            ::||||:   |||||||||||||||||||.||.|||||||.:|||||||||||||||||||||||
Zfish   452 VIQQQQQREGEGPEGCNLFIYHLPQEFGDNELMQMFLPFGTVISSKVFMDRATNQSKCFGFVSFD 516

Human   450 NPASAQAAIQAMNGFQIGMKRLKVQLKRPKDPGHPY 485
            |||||||||||||||||||||||||||||||...||
Zfish   517 NPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CELF5	NP_068757.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		18/74 (24%)
		RRM1_CELF3_4_5_6	40..126	CDD:410041	75/85 (88%)
		half-pint	46..>372	CDD:130706	242/357 (68%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	69/88 (78%)
		RRM3_CELF3_4_5_6	396..474	CDD:241083	73/77 (95%)
celf5a	XP_021325030.1	RRM1_CELF3_4_5_6	73..159	CDD:241076	75/85 (88%)
		RRM	<80..436	CDD:330708	241/356 (68%)
		RRM2_CELF3_4_5_6	165..254	CDD:241079	69/88 (78%)
		RRM3_CELF3_4_5_6	463..541	CDD:241083	73/77 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341031
Domainoid	1	1.000	260	1.000	Domainoid score	I9121
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75172
Inparanoid	1	1.050	698	1.000	Inparanoid score	I4288
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		oto43349
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.270