Protein Alignment CELF5 and bru1

DIOPT Version :10

• Sequence 1: NP_068757.2
• Gene: CELF5 / 60680
• HGNCID: 14058
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_723737.1
• Gene: bru1 / 34648
• FlyBaseID: FBgn0000114
• Length: 810
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 211/485 - (43%)
• Similarity: 280/485 - (57%)
• Gaps: 46/485 - (9%)

Human    25 GSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCA 89
            |...|:|           |.||:||||:|:.:||..|:.:||::|.::.:.||:|..||:.|||.
  Fly   348 GEKEPDP-----------DNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCC 401

Human    90 FLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLF 154
            |:|:..|.:|:|||.|||..|||.||..|||:||||||:|  .:||||||||||:.:|.||.:||
  Fly   402 FVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENR--NERKLFVGMLNKKLNENDVRKLF 464

Human   155 QPFGVIDECTVLRGPDGSSKGCAFVKFSSHTEAQAAIH-ALHGSQTMPGASSSLVVKFADTDKER 218
            :..|.|:||||||..:|.|||||||.|::...|.:||. .|..::.|.|.:|.||||||||.||:
  Fly   465 EVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEK 529

Human   219 TLRRMQQMVGQLGILTPSLTLPFSPYSAYAQALMQQQTTVLSTSGSYLSPGV---AFSPCHIQQI 280
            ..:::||:...|..|..::.:|.      .|......|.:|.......||.:   |.:|..||.:
  Fly   530 EQKKIQQIQANLWNLASNINIPL------GQTATSVTTPILPNPPQQPSPVLGADAITPASIQLL 588

Human   281 GAVSLNGLPATPIAPASGL---HSPPLLGTTAV--PGLVAPIT-NGFAGVVPFPGGHPALETVYA 339
            ..:...||....:...:||   .|.....|:||  .||:.|:| ...|.:....  .|:|....|
  Fly   589 QQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMT--QPSLSNAAA 651

Human   340 NGLV---PYPAQSPTVAETL----HPAFSGVQQYTAMYP------TAAITPIAH-SVPQPPPLLQ 390
            ....   |..||....|..|    :|..|......|..|      ..:.:|:|. ::........
  Fly   652 AAAAATSPGSAQLTNTAALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAAAA 716

Human   391 QQQREGPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDNPASAQ 455
            .:|.|||||||||||||||||.||:|...||||||:||:|||:|:.|:.||||||||||||.|||
  Fly   717 GKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQ 781

Human   456 AAIQAMNGFQIGMKRLKVQLKRPKDPGHPY 485
            .||:||||||:|.||||||||:||| ..||
  Fly   782 VAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF5	NP_068757.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		3/14 (21%)
		RRM1_CELF3_4_5_6	40..126	CDD:410041	43/85 (51%)
		half-pint	46..>372	CDD:130706	133/348 (38%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	44/80 (55%)
		RRM3_CELF3_4_5_6	396..474	CDD:241083	60/77 (78%)
bru1	NP_723737.1	RRM1_CELF1_2_Bruno	356..437	CDD:410040	41/80 (51%)
		SF-CC1	<435..789	CDD:273721	149/363 (41%)
		RRM_SF	443..524	CDD:473069	44/80 (55%)
		RRM3_Bruno_like	722..800	CDD:241084	60/77 (78%)