Protein Alignment CELF6 and NAM8

DIOPT Version :10

• Sequence 1: NP_443072.3
• Gene: CELF6 / 60677
• HGNCID: 14059
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_011954.1
• Gene: NAM8 / 856486
• SGDID: S000001128
• Length: 523
• Species: Saccharomyces cerevisiae
• Alignment Length: 463
• Identity: 98/463 - (21%)
• Similarity: 159/463 - (34%)
• Gaps: 134/463 - (28%)

Human     2 AAAPGGSAQPAGPGPRLGFSTADSGVGMS--GLNPGPAVPMKDHDAIKLFVGQIPRGLDEQDLKP 64
            |....|...|..|..:|..:.|.|....|  .||     .:|..:...:|||.:...:.|..
Yeast   122 ALLKNGMLIPNFPNKKLKLNWATSSYSNSNNSLN-----NVKSGNNCSIFVGDLAPNVTESQ--- 178

Human    65 LFEEFGRIYELT----VLKDRLTGLHKGCAFLTYCARD--------------------------- 98
            |||.|...|..|    ::.|::||:.||..|:.:...|
Yeast   179 LFELFINRYASTSHAKIVHDQVTGMSKGYGFVKFTNSDEQQLALSEMQGVFLNGRAIKVGPTSGQ 243

Human    99 --------------SAL-----------KAQSALHEQKTLPGMNR--------PIQVKPAASEGR 130
                          |:|           |.||.|.......|..|        |:|.:|:.:...
Yeast   244 QQHVSGNNDYNRSSSSLNNENVDSRFLSKGQSFLSNGNNNMGFKRNHMSQFIYPVQQQPSLNHFT 308

Human   131 G-EDRKLFVGMLGKQQGEEDVRRLFQPFGHIEECTVLRSPDGTSKGCAFVKFGSQGEAQAAIRGL 194
            . .:..:|:|.|.....|:::|..|||||.|   ..::.|.|  |.|.||::..:..|:|||.|:
Yeast   309 DPNNTTVFIGGLSSLVTEDELRAYFQPFGTI---VYVKIPVG--KCCGFVQYVDRLSAEAAIAGM 368

Human   195 HGSRTMAGASSSLVVKLADTDRERALRRMQQMAGHLGAFHPAPLPLGACGAYTTAILQHQAALLA 259
            .|   ...|:|.:.:....:.::.||.:...::..|                  .:.|.|..|
Yeast   369 QG---FPIANSRVRLSWGRSAKQTALLQQAMLSNSL------------------QVQQQQPGL-- 410

Human   260 AAQGPGLGPVAAVAAQMQHVAAFSLVAAPLLPAAAANSPPGSGPGTLPGLPAPIGVNGFGPLTPQ 324
              |.|..|.:.:           |...||:||....:|.      .|||...   :|...|.. .
Yeast   411 --QQPNYGYIPS-----------STCEAPVLPDNNVSST------MLPGCQI---LNYSNPYA-N 452

Human   325 TNGQPGSD--TLYNNGLSPYPAQSPGVADPLQQAYAGMHHYAAAYPSAYAPVSTAFPQQPSALPQ 387
            .||. ||:  :.|:|..:.....:..:||......:|..........:.|.|::.     :|:..
Yeast   453 ANGL-GSNNFSFYSNNNATNTQATSLLADTSSMDLSGTGGQQVIMQGSEAVVNST-----NAMLN 511

Human   388 QQREGPEG 395
            :..:|..|
Yeast   512 RLEQGSNG 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF6	NP_443072.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		9/33 (27%)
		RRM1_CELF3_4_5_6	41..127	CDD:410041	29/149 (19%)
		PABP-1234	<48..390	CDD:130689	85/408 (21%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	25/79 (32%)
		RRM3_CELF3_4_5_6	392..470	CDD:241083	2/4 (50%)
NAM8	NP_011954.1	RRM1_NGR1_NAM8_like	55..144	CDD:410023	5/21 (24%)
		RRM2_SECp43_like	162..241	CDD:409781	17/81 (21%)
		RRM3_NGR1_NAM8_like	312..383	CDD:409782	25/78 (32%)