DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CELF6 and HSH49

DIOPT Version :9

Sequence 1:	NP_443072.3	Gene:	CELF6 / 60677	HGNCID:	14059	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_014964.1	Gene:	HSH49 / 854497	SGDID:	S000005846	Length:	213	Species:	Saccharomyces cerevisiae

Alignment Length:	202	Identity:	43/202 - (21%)
Similarity:	76/202 - (37%)	Gaps:	45/202 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    48 LFVGQIPRGLDEQDLKPLFEEFGRIYELTVLKDRLTGLHKGCAFLTYCAR--------------- 97
            ::||.|...:.::.|..||.:...:..:...||::...::|.||:.:..:
Yeast    11 VYVGNIDPRITKEQLYELFIQINPVLRIKYPKDKVLQAYQGYAFIEFYNQGDAQYAIKIMNNTVR 75

Human    98 --DSALKAQSALHEQKT--LPGMNRPIQVKPAASEGRGEDRKLFVGMLGKQQGEEDVRRLFQPFG 158
              |..:|.:...:...|  ||.......:.|.|        |||:..|......:.:.::|..||
Yeast    76 LYDRLIKVRQVTNSTGTTNLPSNISKDMILPIA--------KLFIKNLADSIDSDQLVKIFNKFG 132

Human   159 H-IEECTVLRSPDGTSKGCAFVKFGSQGEAQAAIRGLHGSRTMAGASSSLVVKLA---------- 212
            . |.|..:....:|..| ||:|.|....:|..||:.|:....   |::.:.|..|
Yeast   133 KLIREPEIFYLSNGKLK-CAYVYFEDFEKADLAIKSLNNQLV---ANNRITVDYAFKENGKGNAK 193

Human   213 ---DTDR 216
               |.||
Yeast   194 YGDDVDR 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CELF6	NP_443072.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		RRM1_CELF3_4_5_6	41..127	CDD:241076	17/97 (18%)
		ELAV_HUD_SF	48..477	CDD:273741	43/202 (21%)
		RRM2_CELF3_4_5_6	133..213	CDD:241079	22/93 (24%)
		RRM3_CELF3_4_5_6	392..470	CDD:241083
HSH49	NP_014964.1	PABP-1234	10..>208	CDD:130689	43/202 (21%)
HSH49	NP_014964.1	RRM1_SF3B4	11..85	CDD:409771	13/73 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010