Protein Alignment ALX4 and alx4a

DIOPT Version :10

• Sequence 1: NP_068745.2
• Gene: ALX4 / 60529
• HGNCID: 450
• Length: 411
• Species: Homo sapiens
• Sequence 2: XP_001340966.1
• Gene: alx4a / 100006399
• ZFINID: ZDB-GENE-070712-3
• Length: 368
• Species: Danio rerio
• Alignment Length: 415
• Identity: 258/415 - (62%)
• Similarity: 303/415 - (73%)
• Gaps: 51/415 - (12%)

Human     1 MNAETCVSYCESPAAAMDAYYSP-VSQSRE-GSSPFRAFPGGD-KFGTTFLSAAAKAQGFGDAKS 62
            |||||||||||  ..:||:|||| ..|.|: .::|||.|...| |:...||:  .|.||:|:
Zfish     1 MNAETCVSYCE--MTSMDSYYSPSAPQGRDHQANPFRTFQASDTKYSPAFLT--NKGQGYGE--- 58

Human    63 RARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRG 127
              :.|:..|.....|::.|| .|:|||:                              ||::||.
Zfish    59 --KSGSPFQQECQSLDATAG-EGTFNKY------------------------------HLFMQRS 90

Human   128 ACKTPPDGSLKLQEGSSGHSAALQVPCYAKESS-LGEPELPPDSDTVGMDSSYLSVKEAGVKGPQ 191
            :||||||.| |||:.:|||:..| :.||.|:|: |.:.|||.:||..|||.||||||::|||.||
Zfish    91 SCKTPPDSS-KLQQENSGHNGGL-IACYGKDSTGLTDSELPQNSDPAGMDGSYLSVKDSGVKSPQ 153

Human   192 DRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEA 256
             :|:|:|.|||:|.:.|||||||||||||||||||||||||||||||||||||||||:|||||||
Zfish   154 -QATSELASPLDKTEGESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEA 217

Human   257 RVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPAC 321
            ||||||||||||||||||||||||||||||||||||||||.|||||||||||:|.:.||||||.|
Zfish   218 RVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRPENYAQIQNPSWIGGSSAASPVPGC 282

Human   322 VVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGSLFGAASLSPGLNGYELNGEP 386
            |||||.|.:||.||.|    .||.|:|||.|...|||:||||||||||:..:..|:|||:||.:|
Zfish   283 VVPCDSVTSCMPPHPH----AASGVSDFLGVPSPGSHMGQTHMGSLFGSPGMGTGINGYDLNMDP 343

Human   387 DRKTSSIAALRMKAKEHSAAISWAT 411
            |||:|||||||||||||||||||||
Zfish   344 DRKSSSIAALRMKAKEHSAAISWAT 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..145		21/69 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..219		22/34 (65%)
		Homeodomain	215..271	CDD:459649	54/55 (98%)
		OAR	387..405	CDD:461067	16/17 (94%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	391..404		12/12 (100%)
alx4a	XP_001340966.1	Homeodomain	176..232	CDD:459649	54/55 (98%)
		OAR	344..362	CDD:461067	16/17 (94%)