DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALX4 and alx4a

DIOPT Version :9

Sequence 1:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens
Sequence 2:	XP_001340966.1	Gene:	alx4a / 100006399	ZFINID:	ZDB-GENE-070712-3	Length:	368	Species:	Danio rerio

Alignment Length:	415	Identity:	258/415 - (62%)
Similarity:	303/415 - (73%)	Gaps:	51/415 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNAETCVSYCESPAAAMDAYYSP-VSQSRE-GSSPFRAFPGGD-KFGTTFLSAAAKAQGFGDAKS 62
            |||||||||||  ..:||:|||| ..|.|: .::|||.|...| |:...||:  .|.||:|:
Zfish     1 MNAETCVSYCE--MTSMDSYYSPSAPQGRDHQANPFRTFQASDTKYSPAFLT--NKGQGYGE--- 58

Human    63 RARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRG 127
              :.|:..|.....|::.|| .|:|||:                              ||::||.
Zfish    59 --KSGSPFQQECQSLDATAG-EGTFNKY------------------------------HLFMQRS 90

Human   128 ACKTPPDGSLKLQEGSSGHSAALQVPCYAKESS-LGEPELPPDSDTVGMDSSYLSVKEAGVKGPQ 191
            :||||||.| |||:.:|||:..| :.||.|:|: |.:.|||.:||..|||.||||||::|||.||
Zfish    91 SCKTPPDSS-KLQQENSGHNGGL-IACYGKDSTGLTDSELPQNSDPAGMDGSYLSVKDSGVKSPQ 153

Human   192 DRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEA 256
             :|:|:|.|||:|.:.|||||||||||||||||||||||||||||||||||||||||:|||||||
Zfish   154 -QATSELASPLDKTEGESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEA 217

Human   257 RVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPAC 321
            ||||||||||||||||||||||||||||||||||||||||.|||||||||||:|.:.||||||.|
Zfish   218 RVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRPENYAQIQNPSWIGGSSAASPVPGC 282

Human   322 VVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGSLFGAASLSPGLNGYELNGEP 386
            |||||.|.:||.||.|    .||.|:|||.|...|||:||||||||||:..:..|:|||:||.:|
Zfish   283 VVPCDSVTSCMPPHPH----AASGVSDFLGVPSPGSHMGQTHMGSLFGSPGMGTGINGYDLNMDP 343

Human   387 DRKTSSIAALRMKAKEHSAAISWAT 411
            |||:|||||||||||||||||||||
Zfish   344 DRKSSSIAALRMKAKEHSAAISWAT 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145		21/69 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		22/34 (65%)
		Homeobox	218..270	CDD:278475	50/51 (98%)
		OAR	387..404	CDD:281777	15/16 (94%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404		12/12 (100%)
alx4a	XP_001340966.1	Homeobox	179..231	CDD:278475	50/51 (98%)
alx4a	XP_001340966.1	OAR	344..361	CDD:281777	15/16 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332241
Domainoid	1	1.000	176	1.000	Domainoid score	I14833
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7229
Inparanoid	1	1.050	477	1.000	Inparanoid score	I6807
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39878
OrthoDB	1	1.010	-	-		D243480at7742
OrthoFinder	1	1.000	-	-		FOG0009177
OrthoInspector	1	1.000	-	-		otm26733
orthoMCL	1	0.900	-	-		OOG6_112174
Panther	1	1.100	-	-	LDO	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8021
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440