Protein Alignment ELAC2 and elac2

DIOPT Version :10

• Sequence 1: NP_060597.4
• Gene: ELAC2 / 60528
• HGNCID: 14198
• Length: 826
• Species: Homo sapiens
• Sequence 2: XP_031750010.1
• Gene: elac2 / 733896
• XenbaseID: XB-GENE-923106
• Length: 835
• Species: Xenopus tropicalis
• Alignment Length: 808
• Identity: 504/808 - (62%)
• Similarity: 632/808 - (78%)
• Gaps: 24/808 - (2%)

Human     1 MW---ALCSLLRSAAGRTMSQGRTISQA-PARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQ 61
            ||   |||......:...||:...:.:| .:|:::|.||.|||::.||||...|.|.||.|||:|
 Frog     1 MWLRLALCERPHGLSRFAMSEPSNLVRAFSSRKDKPPKDTLRHIKRREKRQGVGQSNGPATVYVQ 65

Human    62 VVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMIL 126
            |..||||||||::||||||||||||||||.||||||||||:|||||||||||:|:|||||||:||
 Frog    66 VAGAGSRDSGASVYVFSEFNRYLFNCGEGTQRLMQEHKLKIARLDNIFLTRMNWANVGGLSGLIL 130

Human   127 TLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQR- 190
            ||::||||||||||||||:||||||::|||||:||||||||::...|.|:||||||:|:.|...
 Frog   131 TLRDTGLPKCVLSGPPQLQKYLEAIRVFSGPLQGIELAVRPYTDAMYSDDTMTVYQVPLFSSAAP 195

Human   191 RGKHQPWQSPERPLSRLSPERSSDSESNEN-EPHLP--HGVSQ-------RRGVRDSSLVVAFIC 245
            :.......||.|     ||||.|.::|.:: |.|..  .|:|.       |...|||||||:|||
 Frog   196 KTTTVGCYSPPR-----SPERVSTTQSQKDVEGHFRQIEGISSLKREDIGRLSKRDSSLVVSFIC 255

Human   246 KLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREILAEELCTPPDPGAAFVVVE 310
            |||.|:|||:||||||:|||||||||.|||:.:|.|||:|::||||..|::|||.|||..|:|||
 Frog   256 KLHDKKGNFIVLKAKELGLPVGTAAIGPIISELKSGKSVTYQGREIFPEDVCTPADPGPIFIVVE 320

Human   311 CPDESFIQPICENATFQRYQ-GKADAPVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENC 374
            ||.|.|:.|:.||.||:||| .|:.:|||||:||.|.|:|..|||..||::|||.|:||:||||.
 Frog   321 CPTEEFVMPVVENETFKRYQEKKSGSPVALVIHMTPESILHSSRYWHWMKQFGPQTEHLILNENT 385

Human   375 ASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAII 439
            :::|||||:||||||||:||:|||.|.:.:.|:|.|...  .|:|||||||||||:.||||||:.
 Frog   386 STLHNLRSYKIQTQLNLVHPEIFPQLANVQKKEERPEFF--GVRGECLLKYQLRPKLEWQRDAVT 448

Human   440 TCNPEEFIVEALQLPNFQQSVQEYRRSAQ-DGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATL 503
            :.|.|||:.||::||.|.::::..:.:.: ||....|.:.||||:||||||||:|||.||||:||
 Frog   449 SNNTEEFVKEAMELPGFVEALENCKLTLKLDGAFTGESKGQYPEVIFLGTGSAVPMKTRNVSSTL 513

Human   504 VNISPDTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERALAS 568
            ||:||..||||||||||||||.||||:.||.||..|:|:||||:||||||||.:||.:|||.|.:
 Frog   514 VNVSPSHSLLLDCGEGTFGQLHRHYGENVDEVLSKLSAIFVSHIHADHHTGLLNILFERERGLVT 578

Human   569 LGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLRTCD 633
            .|||..|:.|:.|..|..||.||||.||::|||:::||||.|.:|.|..|...:.|::|.|....
 Frog   579 CGKPHTPVSVIGPPLLMTWLNQYHNHCQDILHHMNLIPAKYLTDGTEALSLKNKNLLASFLEAYQ 643

Human   634 LEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAV 698
            ||:|||||||||::|:.|::||.||||:|||||||||:|||:|||||:||||||||||||||||:
 Frog   644 LEQFQTCLVRHCRNAYACSVVHRSGWKLVYSGDTMPCDALVQMGKDASLLIHEATLEDGLEEEAI 708

Human   699 EKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFSEKVGVAFDHMKVCFGDFPTMPKL 763
            |||||||||||.|||:|||.|||||||||||||:||||.:||||||::||||::..|:..|:|||
 Frog   709 EKTHSTTSQAIGVGMKMNANFIMLNHFSQRYAKLPLFSSDFSEKVGISFDHMRINLGNVRTVPKL 773

Human   764 IPPLKALFAGDIEEMEERREKRELRQVR 791
            :.|||.|||.|:||:|||||||||:|:|
 Frog   774 VNPLKVLFAEDLEELEERREKRELKQMR 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ELAC2	NP_060597.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..51		14/35 (40%)
		RNaseZ_ELAC2-N-term-like_MBL-fold	60..311	CDD:293854	170/261 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..231		13/53 (25%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	483..688	CDD:293804	133/204 (65%)
		metallo-hydrolase-like_MBL-fold	<656..730	CDD:451500	64/73 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	798..826
elac2	XP_031750010.1	metallo-hydrolase-like_MBL-fold	64..321	CDD:451500	170/261 (65%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	493..698	CDD:293804	133/204 (65%)