Protein Alignment ELAC2 and Elac2

DIOPT Version :10

• Sequence 1: NP_060597.4
• Gene: ELAC2 / 60528
• HGNCID: 14198
• Length: 826
• Species: Homo sapiens
• Sequence 2: XP_006534128.1
• Gene: Elac2 / 68626
• MGIID: 1890496
• Length: 836
• Species: Mus musculus
• Alignment Length: 834
• Identity: 679/834 - (81%)
• Similarity: 741/834 - (88%)
• Gaps: 21/834 - (2%)

Human     1 MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAA 65
            ||||.||||....||||||      .|||.||.|||||||||||||||.  .|||||||||||||
Mouse     1 MWALRSLLRPLGLRTMSQG------SARRPRPSKDPLRHLRTREKRGPG--PGGPNTVYLQVVAA 57

Human    66 GSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKE 130
            |.||:|||||||||:|||||||||||||||||||||||||||||||||||||||||.||||||||
Mouse    58 GGRDAGAALYVFSEYNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLCGMILTLKE 122

Human   131 TGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQ 195
            |||||||||||||||||||||||||||||||||||||||||||:||||||||:|||||:|.||.|
Mouse   123 TGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYKDETMTVYQVPIHSERRCGKQQ 187

Human   196 PWQSPERPLSRLSPERSSDSESNENEPHLPH----GVSQRRGVRDSSLVVAFICKLHLKRGNFLV 256
            |.|||....:||||::||||.|.||....|.    |.:::...||.||||||:|||||::|||||
Mouse   188 PSQSPRTSPNRLSPKQSSDSGSAENGQCPPEDSSAGANRKAWGRDPSLVVAFVCKLHLRKGNFLV 252

Human   257 LKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPIC 321
            |||||:|||||||||||||||||||||||:|||||.|||||||||||..|:|||||||.||.|||
Mouse   253 LKAKELGLPVGTAAIAPIIAAVKDGKSITYEGREIAAEELCTPPDPGLVFIVVECPDEGFILPIC 317

Human   322 ENATFQRYQGKADAPVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQ 386
            ||.||:|||.:||||||||||:||.|||:||||||||||||||||||:|||||.|||||||||||
Mouse   318 ENDTFKRYQAEADAPVALVVHIAPESVLIDSRYQQWMERFGPDTQHLILNENCPSVHNLRSHKIQ 382

Human   387 TQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEAL 451
            |||:||||||||.||||..|:||.|||||.|:|||||||||||:||||||..:.||.:|||.|||
Mouse   383 TQLSLIHPDIFPQLTSFYSKEEGSTLSVPTVRGECLLKYQLRPKREWQRDTTLDCNTDEFIAEAL 447

Human   452 QLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISPDTSLLLDC 516
            :||:||:||:|||::.|:.|||||||||||||:||||||||||||||||:||||:|||.|:||||
Mouse   448 ELPSFQESVEEYRKNVQENPAPAEKRSQYPEIVFLGTGSAIPMKIRNVSSTLVNLSPDKSVLLDC 512

Human   517 GEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERAL-----ASLGKPLHPL 576
            |||||||||||||.|:||||.:|.|||||||||||||||.:||||||.||     ||||||..||
Mouse   513 GEGTFGQLCRHYGQQIDRVLCSLTAVFVSHLHADHHTGLLNILLQREHALRSFFQASLGKPFQPL 577

Human   577 LVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLRTCDLEEFQTCL 641
            |||||.||:||||||||.|||:|||:|||||||||:|||:|:..:|||||.||.|||||||||||
Mouse   578 LVVAPTQLRAWLQQYHNHCQEILHHVSMIPAKCLQKGAEVSNTTLERLISLLLETCDLEEFQTCL 642

Human   642 VRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAVEKTHSTTS 706
            ||||||||||||||:||||||||||||||||||:|||||||||||||||||||||||||||||||
Mouse   643 VRHCKHAFGCALVHSSGWKVVYSGDTMPCEALVQMGKDATLLIHEATLEDGLEEEAVEKTHSTTS 707

Human   707 QAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFSEKVGVAFDHMKVCFGDFPTMPKLIPPLKALF 771
            |||:|||||||||||||||||||||:|||||:|:||||:||||||||||||||:|||||||||||
Mouse   708 QAINVGMRMNAEFIMLNHFSQRYAKIPLFSPDFNEKVGIAFDHMKVCFGDFPTVPKLIPPLKALF 772

Human   772 AGDIEEMEERREKRELRQVRAALLSRELAGGLEDGEPQQKRAHTEE---PQAKK 822
            |||||||.|||||||||.||||||::: |...||.|||||||||:|   ||:||
Mouse   773 AGDIEEMVERREKRELRLVRAALLTQQ-ADSPEDREPQQKRAHTDEPHSPQSKK 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ELAC2	NP_060597.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..51		24/34 (71%)
		RNaseZ_ELAC2-N-term-like_MBL-fold	60..311	CDD:293854	209/254 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..231		22/46 (48%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	483..688	CDD:293804	174/209 (83%)
		metallo-hydrolase-like_MBL-fold	<656..730	CDD:451500	70/73 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	798..826		17/28 (61%)
Elac2	XP_006534128.1	RNaseZ_ELAC2-N-term-like_MBL-fold	52..307	CDD:293854	209/254 (82%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	479..689	CDD:293804	174/209 (83%)