Protein Alignment FASTKD5 and CG2124

DIOPT Version :10

• Sequence 1: NP_068598.1
• Gene: FASTKD5 / 60493
• HGNCID: 25790
• Length: 764
• Species: Homo sapiens
• Sequence 2: NP_572638.1
• Gene: CG2124 / 31989
• FlyBaseID: FBgn0030217
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 684
• Identity: 140/684 - (20%)
• Similarity: 265/684 - (38%)
• Gaps: 143/684 - (20%)

Human   113 ENMRVFLQLRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNLQAQVIVDYL-----CKLSS 172
            ::::.:..|||.        ....|.|..|||.:     |...:...|.:..|:|     |....
  Fly    44 DSLKPYAILRPR--------DSAWQDLPASEGFM-----RPQPDASAADLYADFLGLVRHCNRME 95

Human   173 LPAEQHPVLLGSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGIPHS---HSMLDVYET---K 231
            |.       :..:.:....:...:::.....:.|:..|.|...|.:|.|   .:.::::.|   :
  Fly    96 LK-------ISDSRYEAFTRCFCEQLHRLTDEQLLGSLSALAELPVPESPKAKNYMEIWNTLDIE 153

Human   232 CCHQVWEMNMDQLLLVADLWRYLGR-KVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIGENRQVS 295
            ||.::...:.:|||||:|.|..||. ::..::.:....|....:.|...||||.:::....|:..
  Fly   154 CCRRIERWSSEQLLLVSDAWYRLGLVRIGEYVWLALKKLGRKLRKLPPEQLVHSMFLCNLLRRPV 218

Human   296 QDLMQKLESLILKYIDLINLEEVGTICLGFFKSST-----NLSEFVMRKIGDLACANIQHLSSRS 355
            .::.. .|..:.:.:|.:.|.|:|.:.:||||:.|     .|...:.:::|    :.:..:....
  Fly   219 FEMFD-FELNLARCVDQMTLSELGVMAMGFFKTQTPIRNPELLTQLYQRLG----SELDTVEDIV 278

Human   356 LVNIVKMFRF-THVDHINFMKQIGEIAPQRIPSLGVQGVMHLTLYCSALRFLNEGVMNAVAASLP 419
            ||.::|:.|: :.:..:..:|::......::..:.:...:|:.|....|:..|:.::..:.....
  Fly   279 LVALLKVLRYSSKLPQVEPLKKMLSALESQVDRVSLLTCLHMALLGCELQTCNDALVERILLRFE 343

Human   420 PRVAHCRSKDVAKILWSFGTLNYKPPNAEE--FYSSLISEIHRKMPEFNQYPEHLPTCLLGLAFL 482
            ..:...|.||:.:|.......|....:..|  ....|...:.:::.|..::|.....||..|...
  Fly   344 RELETARLKDMERICLVMALFNITTKSGVERRLAERLPDLLRQRIEEILRHPRCFSNCLQFLTMR 408

Human   483 EYFPVELIDFALSPGFVRLAQERTKFDLLKELYTLDGTVGIECPDYRGNRLS-THLQQEGSELLW 546
            ..:.:||:..||.|.|::.|.......  :|.:.|||...:..|:|:|..:: ...||.|.....
  Fly   409 GVYDLELLGVALEPRFLKHAYPSGLPG--REYFHLDGFARLLGPEYQGALVTEKQRQQMGRNYTQ 471

Human   547 YLAEKD----MNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRSSDLEVQLD-VNLKPLPFNRE 606
            |:.::|    :|:....|..:....||:..|...||  |||.....|:.:..| ...|.|..|.|
  Fly   472 YIPDRDGRFKLNNTDRILVEIRDAITMIHRPVTFKH--ILPQYDRCDVVLCYDRRQRKALSINGE 534

Human   607 ATPAENVAKLRLEHVGVSLTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENKAA--------V 663
            |..         ::.|..||            |.|..|             |.|||        :
  Fly   535 ACQ---------DYSGEILT------------RKHLLG-------------ERKAADDQLVTVVI 565

Human   664 PLGGFLCNVADKSGAMEMAGLCPAACMQTPRMKLAVQFTNRNQYCYGSRDLLGLHNMKRRQLARL 728
            .:.|:...:.||.                       :||             |..:||.|||.:|
  Fly   566 VIAGWNNVIRDKD-----------------------RFT-------------GQMDMKLRQLRQL 594

Human   729 GYRVVELSYWEWLPL---------LKRTRLEKLA 753
            |::.:.:.:.||..|         ||| ||.::|
  Fly   595 GHQPLVIYWHEWRELENSADRQDFLKR-RLSQIA 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FASTKD5	NP_068598.1	RESC6-like	166..442	CDD:480594	53/293 (18%)
		FAST_1	430..503	CDD:461999	15/74 (20%)
		FAST_2	511..602	CDD:462448	25/96 (26%)
		RAP	699..758	CDD:214932	19/64 (30%)
CG2124	NP_572638.1	RESC6-like	95..>251	CDD:480594	35/163 (21%)
		RAP	565..622	CDD:214932	19/93 (20%)