Protein Alignment RNF6 and mura

DIOPT Version :10

• Sequence 1: NP_005968.1
• Gene: RNF6 / 6049
• HGNCID: 10069
• Length: 685
• Species: Homo sapiens
• Sequence 2: NP_731367.2
• Gene: mura / 41145
• FlyBaseID: FBgn0037705
• Length: 1173
• Species: Drosophila melanogaster
• Alignment Length: 882
• Identity: 163/882 - (18%)
• Similarity: 277/882 - (31%)
• Gaps: 275/882 - (31%)

Human     2 NQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQF------------INELNDEDYRL 54
            :.:.|.||.......|:..|||.|....|.:..::.:..||:            ..:.|.:...|
  Fly   302 SSNTSSSDQNQHNPPPRSQNHHPNPHHSQYQYQYQYQYRYQYHPPHQYHPLHSPQQQTNRQSLPL 366

Human    55 MRDHN--------------LLGTPGEITS------------------------EELQQRLDGVKE 81
            .|.::              ....|.::.:                        ::.|.:::....
  Fly   367 TRTNSNSINATTFNSTNPTTNSNPTDVVNVNSCTDIIPYGSSSTSSSASSMLPQQQQHQINNASA 431

Human    82 QLAS---------QPDL-----------------------------RDGTNYRDSEVPRESSHED 108
            .:.|         .|:|                             .|..|||....|.:|
  Fly   432 PINSHSQGQGPGNSPNLGHNHQRGYNNGNNNRGIGNGIVNGNTNGPPDYMNYRRGVCPAQS---- 492

Human   109 SLLEWLNTFRRTGNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIP 173
                  ..:...||...:|...|  .|.....|.||.....:..|:..|       |..:|.|..
  Fly   493 ------RDYSGNGNGNNNGHGHN--GRRYMSDNLNNPSSSMNGLINSGH-------HQRNYNDRN 542

Human   174 LSDSNRDHTANRQQRSTSPVARRTRSQTSVNF---NGSSSNIPRTRLASRGQNPAEG-----SFS 230
            |:    :|..|.:|.. .|..|.....:|.||   .|.|......|..|..|:.|.|     |.|
  Fly   543 LN----NHFGNSEQNG-GPDHRDRAEGSSYNFMRNGGGSGGGGYGRNGSHYQHMAYGNNNGASTS 602

Human   231 T-----LGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENG--ARSN 288
            |     :|.|.:|    :|:..::.|..|.....|....|..|:|...|      ..||  .:..
  Fly   603 TGGPGLMGELPSG----SGLSGSSLSLNNGPGGLNSDSPSRKRRRISGR------PPNGPQPQHR 657

Human   289 VTVRNTNQRLEPI---RLRSTSNSRSRSPIQRQSGTVYHNSQRESR------------------- 331
            ..:.:..|...|:   |||..:.|..:.  |:|.|...|:.|::.:
  Fly   658 CPMAHMQQGSPPLRRPRLRDVATSTQQQ--QQQYGHQVHHPQQQQQQPPSNYHPMHHHQPQPHYV 720

Human   332 PVQQTTRRSVRRR--------GRTRVFLEQDRERERRGTAYTPFSNSRLVSRITVEEGEESSRSS 388
            |.||.....|:|.        |.:             |.|.:..|...::.::.......|.:.:
  Fly   721 PQQQVPPPHVQRSPWDLGSSGGSS-------------GGATSSSSVGPILQQVQAPPQPPSHQQA 772

Human   389 TAVRRHP----TITLDLQVRRI------RPGENRDRDSIANRTRSRVGLAENTVTIESNSGGFRR 443
            ....:.|    ::.:||.:.::      ||.|............::..||...:     .|.:.:
  Fly   773 VGYPQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQARLAPCHL-----HGVYTQ 832

Human   444 TISRLERSGIRTYVSTITVPLRR-----ISENELVEPSSVALRSILRQIMT-------------G 490
            ........|:      ...||::     |...:::..:::..:...|.::.             .
  Fly   833 PFPAAPPPGL------AAPPLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANLGPIEAPGA 891

Human   491 FGELSSLMEADSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDRQAQGDSTE---MHGE 552
            .|...:...|...:.....|.|:..:....:...|.:..|.....::....||..:.:   ...:
  Fly   892 HGHPHAHPHAHPHAHQLPPGIHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQQILFSSD 956

Human   553 NETTQPHTRN----SDSRGGRQLRNPNNL---------------VETGTLPILRLAHFFL----- 593
            ..|..||.|.    :.:.|.|.:..|.:|               :..|.| :..||.|.|
  Fly   957 RRTFPPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQATSGIINPGFL-LNFLAMFPLSPYNQ 1020

Human   594 -------LNESDDDDRI------------RGLTKEQIDNLSTRHYE---HNSIDSELGKICSVCI 636
                   .||:::.:.:            ||||:.:||.|.:..:.   ||...|.    |.||:
  Fly  1021 HDLSSGDTNETENYEALLSLAERLGEAKPRGLTRNEIDQLPSYKFNPEVHNGDQSS----CVVCM 1081

Human   637 SDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICR 673
            .|:.....||.|||.||||..|:|:||..|.||||||
  Fly  1082 CDFELRQLLRVLPCSHEFHAKCVDKWLRSNRTCPICR 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF6	NP_005968.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..107		9/63 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..142		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..273		31/117 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..345		16/88 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	499..576		14/83 (17%)
		RING-H2_RNF6	630..681	CDD:438335	24/44 (55%)
mura	NP_731367.2	RING-H2_RNF38-like	1073..1118	CDD:438135	23/48 (48%)