Protein Alignment SAV1 and sav

DIOPT Version :10

• Sequence 1: NP_068590.1
• Gene: SAV1 / 60485
• HGNCID: 17795
• Length: 383
• Species: Homo sapiens
• Sequence 2: NP_788721.1
• Gene: sav / 252554
• FlyBaseID: FBgn0053193
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 154/590 - (26%)
• Similarity: 217/590 - (36%)
• Gaps: 220/590 - (37%)

Human     1 MLSRKKTKNEVSKPAEVQGKYVKKETSPLL---------RNLMPSFIRHGPTIP----------- 45
            ||||:..:....|.. |.|||:||:|.|.:         |....|..|...|.|
  Fly    15 MLSRRNKEKSQHKEG-VVGKYMKKDTPPDISVINVWSDQRAKKKSLQRCASTSPSCEFHPRSSST 78

Human    46 -RRTDIC-----------------------------LPDSS-----------PNAFSTSGDVVSR 69
             |.|..|                             ||..|           |:.|..|.:.:|:
  Fly    79 SRNTYSCTDSQPDYYHARRAQSQMPLQQHSHSHPHSLPHPSHPHVRSHPPLPPHQFRASSNQLSQ 143

Human    70 NQS------------------FLRTP---------IQRTPHEIMRRESNRLSAPSY------LAR 101
            |.|                  .|:|.         .||:.....|:....|...||      |:.
  Fly   144 NSSNYVNFEQIERMRRQQSSPLLQTTSSPAPGAGGFQRSYSTTQRQHHPHLGGDSYDADQGLLSA 208

Human   102 SLADV---------PREYG---------------SSQSFVTEVSF---AVENGDSGSRYYYSDNF 139
            |.|::         |..|.               :|..|.:.:.|   |:...:...||..:.:.
  Fly   209 SYANMLQLPQRPHSPAHYAVPPQQQQHPQIHQQHASTPFGSTLRFDRAAMSIRERQPRYQPTSSP 273

Human   140 FDGQRKRPL----------------GDRAHEDYRYYE---------------------------- 160
            ...|:::..                |..:.:.|..||
  Fly   274 MQQQQQQQQQQQQQLQHTQLAAHLGGSYSSDSYPIYENPSRVISMRATQSQRSESPIYSNTTASS 338

Human   161 --------YNHDLFQRMPQNQG---------RHASGIGRVAATSLGNL----------------T 192
                    ::|.....:|...|         ..:||..|.|:||:.:|                :
  Fly   339 ATLAVVPQHHHQGHLAVPSGSGGGSLSGSGRGGSSGSVRGASTSVQSLYVPPRTPPSAVAGAGGS 403

Human   193 NHGS-------------EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVE 244
            .:||             |:|||||||:..:|:.|||||||||.:||||:|||||||||.||.||.
  Fly   404 ANGSLQKVPSQQSLTEPEELPLPPGWATQYTLHGRKYYIDHNAHTTHWNHPLEREGLPVGWRRVV 468

Human   245 SSEFGTYYVDHTNKKAQYRHPCAPSVPRY--DQPPPVTYQPQQT-----ERNQSLLVPANPYHTA 302
            |...||||.:....::|.:|||..|...|  ...||...:|:.:     ....:.|||||||...
  Fly   469 SKMHGTYYENQYTGQSQRQHPCLTSYYVYTTSAEPPKAIRPEASLYAPPTHTHNALVPANPYLLE 533

Human   303 EIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELEN 367
            |||.||.||:.|....||:|::.:|.|.:|:.:..||..||.:||..||..||.||:||:.| :|
  Fly   534 EIPKWLAVYSEADSSKDHLLQFNMFSLPELEGFDSMLVRLFKQELGTIVGFYERYRRALILE-KN 597

Human   368 RKQRQ 372
            |:..|
  Fly   598 RRAGQ 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAV1	NP_068590.1	WW	202..232	CDD:238122	20/29 (69%)
		WW	237..266	CDD:238122	12/28 (43%)
		SARAH_Sav	302..368	CDD:439176	29/65 (45%)
sav	NP_788721.1	PAT1	<95..>225	CDD:401645	21/129 (16%)
		WW	425..454	CDD:459800	19/28 (68%)
		SARAH_Sav	533..599	CDD:439176	30/66 (45%)