DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HAPLN2 and hapln2

DIOPT Version :9

Sequence 1:	NP_068589.1	Gene:	HAPLN2 / 60484	HGNCID:	17410	Length:	340	Species:	Homo sapiens
Sequence 2:	NP_001076285.2	Gene:	hapln2 / 558291	ZFINID:	ZDB-GENE-030131-8089	Length:	337	Species:	Danio rerio

Alignment Length:	304	Identity:	177/304 - (58%)
Similarity:	219/304 - (72%)	Gaps:	2/304 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    36 YLLPP-IHEVIHSHRGATATLPCVLGTTPPSYKVRWSKVEPGELR-ETLILITNGLHARGYGPLG 98
            |||.| :...:.:.||..|.||||:...|..|:|:|:|:||.... |.::|||||...:.||.:|
Zfish    33 YLLEPLVFAEVSARRGHAAILPCVMRFKPSHYRVKWTKLEPSSRGVENIVLITNGHADKQYGSVG 97

Human    99 GRARMRRGHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNY 163
            .||.::|.|.||.||.::.:.|||:|.||||||||||||||.:||.:||||||||..:|||:|.:
Zfish    98 PRAALQRAHDLDVSLRLSDLELEDDGSYRCELINGIEDESVIITLRIEGVVFPYQSQKGRYRFTF 162

Human   164 YEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGRGRPGIRSYGP 228
            ::||:||.|||..||||.|||:||||||||||||||.:|:|.||||..|..|||....|||||||
Zfish   163 FDAKEACAEQDATLATYKQLYRAWTEGLDWCNAGWLSDGTVSYPVLHPRPACGGDLLSGIRSYGP 227

Human   229 RDRMRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGG 293
            |.:.|:.||||||||...|.|||:.|:|..:||..||||.||.:||.|.:|::|:|..||:||||
Zfish   228 RHKTRENYDAFCFTSTSKGSVFFIEGQLNFAEAERACRRDGAGLAKTGQIYSSWRFQQLDRCDGG 292

Human   294 WLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCY 337
            ||.||||||||..||..|||:.:|||||||||......||.|||
Zfish   293 WLEDGSVRFPIINPREHCGGIAEPGVRSFGFPSKSMRLYGAYCY 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HAPLN2	NP_068589.1	Ig	49..149	CDD:386229	53/100 (53%)
		Link_domain_HAPLN_module_1	148..241	CDD:239595	61/92 (66%)
		Link_domain_HAPLN_module_2	250..337	CDD:239596	51/86 (59%)
hapln2	NP_001076285.2	IG_like	43..144	CDD:214653	51/100 (51%)
		Ig_LP_like	47..148	CDD:143285	53/100 (53%)
		Link_Domain	147..240	CDD:295393	61/92 (66%)
		Link_domain_HAPLN_module_2	247..336	CDD:239596	52/88 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327562
Domainoid	1	1.000	146	1.000	Domainoid score	I18379
eggNOG	1	0.900	-	-		E1_28IZN
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11045
Inparanoid	1	1.050	384	1.000	Inparanoid score	I8149
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41636
OrthoDB	1	1.010	-	-		D231533at7742
OrthoFinder	1	1.000	-	-		FOG0010272
OrthoInspector	1	1.000	-	-		oto45231
orthoMCL	1	0.900	-	-		OOG6_118969
Panther	1	1.100	-	-	LDO	PTHR22804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6493
SonicParanoid	1	1.000	-	-		X7681
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300