DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRD2 and fs(1)h

DIOPT Version :9

Sequence 1:NP_001186384.1 Gene:BRD2 / 6046 HGNCID:1103 Length:836 Species:Homo sapiens
Sequence 2:NP_001259321.1 Gene:fs(1)h / 31722 FlyBaseID:FBgn0004656 Length:2046 Species:Drosophila melanogaster


Alignment Length:1168 Identity:436/1168 - (37%)
Similarity:531/1168 - (45%) Gaps:446/1168 - (38%)


- Green bases have known domain annotations that are detailed below.


Human    49 ASVPALQLTPANPP------PPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK 107
            :|.|..:..|...|      ||.:...::|||.|||||||.|.|||.:|||.|:|||:|||||.|
  Fly     3 SSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKK 67

Human   108 LGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI 172
            |.||||||||||||||||||:||||||||:|.|.:|||||||.|||:||||.:|:|:|||||||:
  Fly    68 LNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKV 132

Human   173 FLQKVASMPQEEQELVVTIPKNSHKK--------------GAK---------------------- 201
            ||||:.|||:||.||.....|...||              ||.                      
  Fly   133 FLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVS 197

Human   202 -----------------------------------------LAALQGSVTS----AHQVPAVSSV 221
                                                     ::|:.|:|:|    |..:|.:|::
  Fly   198 VAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTM 262

Human   222 SHTALYTPPPEIP------TTVL--NIPHPSVI-----SSPLLKSLHSAGP-------------- 259
                   ||..:|      ||.:  .:..|...     ::.|:.||.:||.              
  Fly   263 -------PPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVN 320

Human   260 ---------------------------------------PLLAVTAA------------------ 267
                                                   |.:||.||                  
  Fly   321 SSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAV 385

Human   268 -PPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDL 331
             ||.||...||||||||||||||..|.      .||...::.|:|:: ..||||.|.:       
  Fly   386 IPPQQPAKIKKGVKRKADTTTPTANAF------ESPYTQMDSKSAKI-ATRRESNRQV------- 436

Human   332 PDSQQQHQSSKKG----------------------------------KLSEQLKHCNGILKELLS 362
                    ..|||                                  |||:.||.||.|||||.|
  Fly   437 --------IGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFS 493

Human   363 KKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYK 427
            |||:.|||||||||||..|||||||||||.||||.||||||:||:|:.|.||||||||:|:||||
  Fly   494 KKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYK 558

Human   428 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKS---------------- 476
            |||||||||||.||||||||.|||.:||||:      .:.|...|....                
  Fly   559 YNPPDHDVVAMGRKLQDVFEMRYANIPDEPV------ANAAHHHGHGHGHGHGHGHGHGHGHGHG 617

Human   477 -----SSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAA 536
                 ...||.:..:|:|||     ||..|.|.|    |:|:|||:.||..|:.:|..:.|::..
  Fly   618 HGHGYGGSSSLKHDASDSSS-----EDSSDTENE----SNSDEERSARLKMLESKLLGLQEEIRK 673

Human   537 LSQGPISKPKRKREKKEKKK-------KRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSG 594
            ||:...:|.|.|::.|||||       ...|..|....|...:..|...|            |||
  Fly   674 LSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGP------------GSG 726

Human   595 --------GGSAALGPSGFGPS------GGS-----GTKLQAGV--------QWRDL-------- 624
                    ||..:|||.|.|.:      |||     |..:..||        |..|:        
  Fly   727 GHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMA 791

Human   625 -------------------------GLLQPPLL--------------------------GFKRFS 638
                                     |.|...|.                          |.|...
  Fly   792 GGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSG 856

Human   639 CLSLPSSQDYRLPKKATKTAPPALPTG-------------------------------------- 665
            ...:.:|.:......|...|..|...|                                      
  Fly   857 AGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANAS 921

Human   666 -------------------YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSL 711
                               :|||||:.::|||||||||||||||||||:||||||||||.|||||
  Fly   922 AGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSL 986

Human   712 RDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQ 776
            |||||:||||||||||||||||||.||.||||||     |.|||.||:|:|...|||:|||||||
  Fly   987 RDSNPDEIEIDFETLKPSTLRELESYVASCLRKK-----THKKPSGKSKDEQMAEKKQELEKRLQ 1046

Human   777 DVSGQLNSTKKPPKKANEKTESSSAQQVAV---SRLSASSSSSDSSSSSSS-SSSSDTSDSDS 835
            ||:|||.::||..|    |.||:|::..||   :.:|:||||||||||||| |||||:|||::
  Fly  1047 DVTGQLGASKKTAK----KDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEA 1105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRD2NP_001186384.1 Bromo_Brdt_I_like 74..180 CDD:99929 81/105 (77%)
Bromo_Brdt_II_like 349..450 CDD:99930 81/100 (81%)
GVQW 616..>651 CDD:290611 10/101 (10%)
BET 676..740 CDD:293640 59/63 (94%)
fs(1)hNP_001259321.1 Bromo_Brdt_I_like 34..140 CDD:99929 81/105 (77%)
COG5076 387..>593 CDD:227408 122/233 (52%)
Bromo_Brdt_II_like 481..581 CDD:99930 81/99 (82%)
BET 951..1015 CDD:293640 59/63 (94%)
BRD4_CDT <2026..2046 CDD:293710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 159 1.000 Domainoid score I4085
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000322
OrthoInspector 1 1.000 - - otm41060
orthoMCL 1 0.900 - - OOG6_100249
Panther 1 1.100 - - LDO PTHR22880
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3378
SonicParanoid 1 1.000 - - X197
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.940

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