Protein Alignment RNF2 and Sce

DIOPT Version :10

• Sequence 1: NP_009143.1
• Gene: RNF2 / 6045
• HGNCID: 10061
• Length: 336
• Species: Homo sapiens
• Sequence 2: NP_477509.1
• Gene: Sce / 43327
• FlyBaseID: FBgn0003330
• Length: 435
• Species: Drosophila melanogaster
• Alignment Length: 430
• Identity: 194/430 - (45%)
• Similarity: 245/430 - (56%)
• Gaps: 120/430 - (27%)

Human    14 SKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIIT 78
            :||||||||||||.|||.|||..||.||||||||||||||||||||.||||||||||||:|||:|
  Fly     9 NKTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVT 73

Human    79 ALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHS 143
            |||||||||||||||||||||||.|||||.|||||||||:||||.||:|:|:.|:..:||||.:|
  Fly    74 ALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNS 138

Human   144 IEEGLKIQAMNRLQRGKKQQIENGSGAEDNGD------------------------------SSH 178
            |.||:|:|:.||.||.:.:....|.|...||:                              :|:
  Fly   139 INEGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASN 203

Human   179 CSNASTHS----NQEAG------------PSNKRTKTSDDSG-------LELD------------ 208
            .||::|:|    |::.|            .||....:|.:||       :::|
  Fly   204 DSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSANSGASTSATRMQVDDASNPPSVRSTP 268

Human   209 -----NNNA-----AMAI-----------DPVMD----GAS----------------EIELVFRP 232
                 |:::     ||::           |..||    |.|                ||||||:|
  Fly   269 SPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTEGDSNIDTEGEGNGELGINDEIELVFKP 333

Human   233 HPTLMEKDDSA-------QTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQ 290
            |||.|..|:..       ..|||||:.||||||||||||:||.|:......|:.::       ..
  Fly   334 HPTEMSADNQLIRALKENCVRYIKTTANATVDHLSKYLAMRLTLDLGADLPEACRV-------LN 391

Human   291 YTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYA 330
            :.||:|....|..:|||:.:|..|::|:||||||||:||:
  Fly   392 FCIYVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF2	NP_009143.1	Interaction with HIP2. /evidence=ECO:0000269|PubMed:11513855	2..179		121/194 (62%)
		RING-HC_RING2	37..113	CDD:438398	69/75 (92%)
		Interaction with nucleosomes via an acidic patch on histone H2A and histone H2B. /evidence=ECO:0000269|PubMed:25355358	93..98		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..208		18/103 (17%)
		RAWUL_RING2	225..330	CDD:340687	52/111 (47%)
Sce	NP_477509.1	COG5222	<10..154	CDD:227547	115/143 (80%)
		RING_Ubox	41..110	CDD:473075	63/68 (93%)
		RAWUL_RING1_like	326..431	CDD:340606	52/111 (47%)