Protein Alignment RNF2 and rnf2

DIOPT Version :10

• Sequence 1: NP_009143.1
• Gene: RNF2 / 6045
• HGNCID: 10061
• Length: 336
• Species: Homo sapiens
• Sequence 2: NP_571288.2
• Gene: rnf2 / 327035
• ZFINID: ZDB-GENE-030131-5243
• Length: 338
• Species: Danio rerio
• Alignment Length: 336
• Identity: 300/336 - (89%)
• Similarity: 314/336 - (93%)
• Gaps: 0/336 - (0%)

Human     1 MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTK 65
            |:|.|||||.||||||||||||||||||||||||||||.||||||||||||||||||||||||||
Zfish     3 MTQTVQTNGVQPLSKTWELSLYELQRTPQEAITDGLEIAVSPRSLHSELMCPICLDMLKNTMTTK 67

Human    66 ECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLAR 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    68 ECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLAR 132

Human   131 INKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNK 195
            |:|||||||||||||||||||||||||||||.|||||||||||||||||||||.|||||||||.|
Zfish   133 ISKHNNQQALSHSIEEGLKIQAMNRLQRGKKHQIENGSGAEDNGDSSHCSNASVHSNQEAGPSIK 197

Human   196 RTKTSDDSGLELDNNNAAMAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLS 260
            ||||||||||::||.......|..:||.||||||||||||||||:|:||||||||||||||||||
Zfish   198 RTKTSDDSGLDMDNATENGGGDIALDGVSEIELVFRPHPTLMEKEDAAQTRYIKTSGNATVDHLS 262

Human   261 KYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPM 325
            |||||||||||:|..||::.:|::.||||||||||.|||.|||||||||||||||||||||||||
Zfish   263 KYLAVRLALEEMRKNGEASPINVEAASEKQYTIYIPTASNQFTVLNGSFSLELVSEKYWKVNKPM 327

Human   326 ELYYAPTKEHK 336
            |||:|||||||
Zfish   328 ELYFAPTKEHK 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF2	NP_009143.1	Interaction with HIP2. /evidence=ECO:0000269|PubMed:11513855	2..179		170/176 (97%)
		RING-HC_RING2	37..113	CDD:438398	74/75 (99%)
		Interaction with nucleosomes via an acidic patch on histone H2A and histone H2B. /evidence=ECO:0000269|PubMed:25355358	93..98		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..208		46/50 (92%)
		RAWUL_RING2	225..330	CDD:340687	90/104 (87%)
rnf2	NP_571288.2	RING-HC_RING2	39..115	CDD:438398	74/75 (99%)
		RAWUL_RING2	227..332	CDD:340687	90/104 (87%)