Protein Alignment TGIF2 and hth

DIOPT Version :10

• Sequence 1: NP_068581.1
• Gene: TGIF2 / 60436
• HGNCID: 15764
• Length: 237
• Species: Homo sapiens
• Sequence 2: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Alignment Length: 151
• Identity: 45/151 - (29%)
• Similarity: 72/151 - (47%)
• Gaps: 17/151 - (11%)

Human     2 SDSDLGEDEGL----LSLAGKR--KRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNL 60
            |::.:|..||.    ...:||:  |:||..||.:..|||.||:.|..:.||||.:|..|:..|.|
  Fly   343 SNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGL 407

Human    61 SVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVL 125
            ::||:.|||||||||::..|:.:.    |:...:...|       |.|.....:...:.:..:::
  Fly   408 TILQVNNWFINARRRIVQPMIDQS----NRAVYTPHPG-------PSGYGHDAMGYMMDSQAHMM 461

Human   126 SLSVCSMPLHSGQGEKPAAPF 146
            .........|.|....|.|.:
  Fly   462 HRPPGDPGFHQGYPHYPPAEY 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGIF2	NP_068581.1	Homeobox_KN	37..75	CDD:428673	19/37 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..106		2/18 (11%)
		Repressive function	103..237		6/44 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..193
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..237
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140
		Homeobox_KN	384..422	CDD:428673	19/37 (51%)