Protein Alignment TGIF2 and mirr

DIOPT Version :10

• Sequence 1: NP_068581.1
• Gene: TGIF2 / 60436
• HGNCID: 15764
• Length: 237
• Species: Homo sapiens
• Sequence 2: NP_001261778.1
• Gene: mirr / 39441
• FlyBaseID: FBgn0014343
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 269
• Identity: 62/269 - (23%)
• Similarity: 86/269 - (31%)
• Gaps: 95/269 - (35%)

Human    21 RRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLP------- 78
            ||.|..:|:...|:.||..|:.|.||::.||:.|:..|.:::.|:..||.||||||..
  Fly   227 RRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWE 291

Human    79 -----------------------DMLRKDGKDPNQFTI--SRRGGKASDVAL--PRGSSPSVLAV 116
                                   |:|  |.||....:.  ..|.|:..|:..  |..|:.|..:.
  Fly   292 PRNRVDDDDANIDDDDDKNTEDNDLL--DAKDSGVGSTDDKDRSGRLGDMMTDRPGESNNSEWSE 354

Human   117 SVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFN 181
            |.|...|      .|..|:...|..|....|   |..|..|                   ...|.
  Fly   355 SRPGSPN------GSPDLYDRPGSMPPGAHP---LFHPAAL-------------------HHHFR 391

Human   182 TPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQ-----------------------------KQ 217
            .|..:||:.........|||.:  .|:|.:..||                             |.
  Fly   392 PPAGSPPDIAAYHHHQQQLLQQ--HQQAQQNSLQTAVGGTAKPRIWSLADMASKDSKDSSSGAKD 454

Human   218 QDPSLPLLH 226
            ..|.||..|
  Fly   455 NHPELPPAH 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGIF2	NP_068581.1	Homeobox_KN	37..75	CDD:428673	15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..106		4/22 (18%)
		Repressive function	103..237		30/155 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..193		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..237		7/43 (16%)
mirr	NP_001261778.1	Homeobox_KN	243..281	CDD:428673	15/37 (41%)