Protein Alignment TGIF2 and caup

DIOPT Version :10

• Sequence 1: NP_068581.1
• Gene: TGIF2 / 60436
• HGNCID: 15764
• Length: 237
• Species: Homo sapiens
• Sequence 2: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Alignment Length: 315
• Identity: 72/315 - (22%)
• Similarity: 104/315 - (33%)
• Gaps: 115/315 - (36%)

Human    15 LAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPD 79
            ||.:||   |..:||...|:.||..|:.|.||::.||:.|:..|.:::.|:..||.||||||..:
  Fly   226 LAARRK---NATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKE 287

Human    80 -----------------MLRKDGK---------------DPNQFTISRRGGKA------------ 100
                             |:..|.|               ||....|....|||
  Fly   288 NKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKL 352

Human   101 ---------------SDVALPRGSSPSVLAVSV----------PAPTNV---------------L 125
                           :..|.|.|:.|...|.|.          |.|..:               |
  Fly   353 DLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQL 417

Human   126 SLSVCSMPLH--SGQGEKPAAPF--PRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPT 186
            .......|.:  .|.|::.:..|  .:..|.....:..|.|...:.:.|:..:     ..|||||
  Fly   418 QHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKPKIWSVADTAA-----CKTPPPT 477

Human   187 ---------PPEQDKEDFSSFQLLVEVALQRAAEMEL----QKQQDPSLPLLHTP 228
                     ||.      |:.|.|....||:..:.:|    |:||....|..|.|
  Fly   478 AAYLGQNFYPPS------SADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGIF2	NP_068581.1	Homeobox_KN	37..75	CDD:428673	15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..106		7/45 (16%)
		Repressive function	103..237		36/168 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..193		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..237		7/20 (35%)
caup	NP_524046.2	Homeobox_KN	245..283	CDD:428673	15/37 (41%)
		IRO	455..472	CDD:214716	3/21 (14%)