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Protein Alignment RNASEL and IRE1

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_011946.1	Gene:	IRE1 / 856478	SGDID:	S000001121	Length:	1115	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	114/535 - (21%)
Similarity:	192/535 - (35%)	Gaps:	161/535 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   267 NDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHP 331
            :|.|.|.:.:|.|..|.|.:|......|:|..:...::     .|::.||..:::|.
Yeast   626 DDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANI-----PNFEQSLKNLVVSE-------- 677

Human   332 PAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGG--IYLGFYEKQEVAVK-- 392
                                                  ||......|  ::.|.::.:.||||
Yeast   678 --------------------------------------KILGYGSSGTVVFQGSFQGRPVAVKRM 704

Human   393 --TFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 455
              .||:   .|..|:..|..|.::.:::.:|.||:....|::.:.||...|:   |:...::|.:
Yeast   705 LIDFCD---IALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQ---DLVESKNVSD 763

Human   456 EEDEFAR-----NVLSSIFKAVQELHLSCGYTHQDLQPQNILI--------DSKKAAH-----LA 502
            |..:..:     ::|..|...|..|| |....|:||:|||||:        |.:..|.     ::
Yeast   764 ENLKLQKEYNPISLLRQIASGVAHLH-SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILIS 827

Human   503 DFDKSIK--------------------WAG--------------------------------DPQ 515
            ||....|                    |..                                ||.
Yeast   828 DFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPF 892

Human   516 EVKR-----DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ--LSPDE-----------ETKDL 562
            ..:|     |:..:|.:..|::.||...|.| |......:::  .|.||           |..||
Yeast   893 TKRRLTRSIDIFSMGCVFYYILSKGKHPFGD-KYSRESNIIRGIFSLDEMKCLHDRSLIAEATDL 956

Human   563 IHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSK 627
            |.::.......|.....:|.||.||....:...|..|.:..:|:.|...|.:|.....|......
Yeast   957 ISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIP 1021

Human   628 SFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDE--EKHKKMKLKIGDPSL 690
            |.| ||.|.::..|..:.: |.|   ::.:.:.|||:.:||...|..:  |...::...:.|...
Yeast  1022 SGD-WTVKFDKTFMDNLER-YRK---YHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFY 1081

Human   691 -YFQKTFPDLVIYVY 704
             ||.|.||:|:|.||
Yeast  1082 DYFTKRFPNLLIGVY 1096

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.