DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and cdk15

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_031748614.1 Gene:cdk15 / 780381 XenbaseID:XB-GENE-961241 Length:435 Species:Xenopus tropicalis


Alignment Length:424 Identity:89/424 - (20%)
Similarity:138/424 - (32%) Gaps:136/424 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   288 IAELLCKRG--ASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHP-----------PAEDWKPQ 339
            :.|:||...  ....||..:....::.:        .|...|::.|           |.....||
 Frog     1 MGEVLCTNAVFGCLCCGSKMRPQEQHQE--------MHTEHEEYFPQELTDFSDVPCPVRSLPPQ 57

Human   340 SSHWGAALKDLHRIYR--------PMIGK------------LKFFIDEKY----KIADTSEGGIY 380
            ..|    ...:.||..        |:.||            |.|.....|    |:.:.|...:|
 Frog    58 WYH----TVQVRRIRSLRARSNSDPLQGKNLGQALQWQRRGLPFGNASSYLNLEKLGEGSYATVY 118

Human   381 LGF--YEKQEVAVKTFC----EGSP-RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 438
            .|.  ...|.||:|...    ||.| .|.||.|.|:..: ::::|..:.....|..|........
 Frog   119 KGISRINGQLVALKVISMKAEEGVPFTAIREGSLLKGLK-HANIVLLHDIIQTRETLTFVFEYVH 182

Human   439 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL------HLSCGYTHQDLQPQNILIDSKK 497
            ..|...:..|.|       .....||...:|:.::.|      |:    .|:||:|||:||....
 Frog   183 TDLAQYMSQHPG-------GLLPYNVRLFMFQLLRGLAYIHHQHI----LHRDLKPQNLLISYIG 236

Human   498 AAHLADFD----KSIK-----------WAGDPQ------EVKRDLEDLGRLVLYV-VKKG----- 535
            ...||||.    |||.           |...|.      :...||:..|...::: :.:|     
 Frog   237 ELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDVLLGATDYSTDLDIWGAGCIFIEMLQGYPAFS 301

Human   536 --SISFEDLK---------AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCL------------ 577
              |..||.|:         |:.:...|.:.|:.:|:.|..:.:.|..:|.|.|            
 Frog   302 GVSDIFEQLEKIWSVIGTPAEDSWPGVSMLPNYKTEWLTLQEYQPFGNVWDGLGRSMGAEDLAEK 366

Human   578 ------------SDLLGHPFFWTWESRYRTLRNV 599
                        .|.|.|.||.|...:...|.:|
 Frog   367 MLKGCPRERISAEDALLHKFFSTLPCQLHQLPDV 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786
ANK 1 24..53
Ank_2 29..122 CDD:289560
ANK 2 58..87
ANK 59..188 CDD:238125
ANK repeat 59..89 CDD:293786
ANK repeat 91..122 CDD:293786
ANK 3 91..120
Ank_2 96..199 CDD:289560
ANK repeat 124..154 CDD:293786
ANK 4 124..153
ANK repeat 167..199 CDD:293786
ANK 5 167..197
Ank_2 172..270 CDD:289560
ANK 196..321 CDD:238125 5/34 (15%)
ANK repeat 201..236 CDD:293786
ANK 6 201..234
2-5A binding (P-loop) 1 229..242
ANK 7 238..268
Ank_2 243..326 CDD:289560 6/39 (15%)
2-5A binding (P-loop) 2 253..275
ANK repeat 272..326 CDD:293786 6/39 (15%)
ANK 8 272..301 3/14 (21%)
ANK 9 303..329 2/25 (8%)
PKc_like 375..587 CDD:304357 64/286 (22%)
Pkinase 387..586 CDD:278497 60/271 (22%)
RNase_RNase-L 590..708 CDD:199218 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
cdk15XP_031748614.1 PKc_like 102..387 CDD:419665 65/296 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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