DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and tnks2

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:NP_001017008.2 Gene:tnks2 / 549762 XenbaseID:XB-GENE-968819 Length:1167 Species:Xenopus tropicalis


Alignment Length:705 Identity:162/705 - (22%)
Similarity:239/705 - (33%) Gaps:246/705 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    12 GPTSSSGRRAAV-EDNHLLIKAVQNEDV----------------------------------DLV 41
            |..:|.|..||. |....|.:|.:|.||                                  |:|
 Frog    11 GSAASHGDMAAAGEPARELFEACRNGDVERVRKLVNADNVNSRDTAGRKSTPLHFAAGFGRKDVV 75

Human    42 QQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVK 106
            :.||:.||||: ..::||..|||||......::|.|||||||||..|.....||...|||.|.:.
 Frog    76 EHLLQSGANVH-ARDDGGLIPLHNACSFGHAEVVSLLLRHGADPNARDNWNYTPLHEAAIKGKID 139

Human   107 LLKLFLSKGAD----------------------------------------------------VN 119
            :..:.|..|||                                                    ||
 Frog   140 VCIVLLQHGADPTIRNTDSRTALDLSDPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVN 204

Human   120 EC---DFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHV 181
             |   |....|....||.|.:||.::.|.:.||:|:.:          .||....|.:|...||.
 Frog   205 -CHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK----------DKGDLVPLHNACSYGHY 258

Human   182 EVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246
            ||.::|: :.||.|||.| :.:...:|...|.:..:|   ..|||.:|||..:.....|:.:.||
 Frog   259 EVTELLV-KRGASVNAMD-LWQFTPLHEAASKNRVEV---CSLLLSYGADPTMLNCHNKSAIDLA 318

Human   247 VE----------------------------KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283
            ..                            ||||.|  .::..:|.:.:|      |||..|...
 Frog   319 PTPQLKEMLSYEFKGHSLLQAAREADLTRVKKHLSL--EIVNFKHPQTHD------TALHCAASS 375

Human   284 ---KLKKIAELLCKRGAST-----DCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQS 340
               |.|::.|||.::||:.     |....:..|.....:.:|:||:.|.||.:    |.|...|:
 Frog   376 PYPKRKQVCELLFRKGANVSEKTKDFLTPLHVASDKAHNDIVEVLIKHEAKVN----ALDNLGQT 436

Human   341 SHWGAALKDLHRIYR----------------PMIGKLKFF-------------IDEKYKIADTSE 376
            |        |||...                |.|..|:.|             :.|....::|..
 Frog   437 S--------LHRAAHCGHLQTCRLLLNSGCDPSIVSLQGFTALQMGNESVQQILQEGLPFSNTDA 493

Human   377 GGIYLGFYEKQEV-AVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 440
            ....|...:..:| .||..|.......|::...||:  ..|....|..          |.:.|..
 Frog   494 DRQLLEAAKAGDVETVKKLCTSQSVNCRDIEGRQST--PLHFAAGYNR----------VAVVEYL 546

Human   441 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFD 505
            |:...|||..:.                 ..:..||.:|.|.|.::  ..:|:......::||..
 Frog   547 LQHGADVHAKDK-----------------GGLVPLHNACSYGHYEV--TELLVKHGAVINVADLW 592

Human   506 K------------------SIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDL 542
            |                  .::...|..:..||    |...|.:||.|....:||
 Frog   593 KFTPLHEAAAKGKYEICKLLLQHGADSTKKNRD----GNTPLDLVKDGDTDIQDL 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 3/8 (38%)
ANK repeat 24..56 CDD:293786 14/65 (22%)
ANK 1 24..53 14/62 (23%)
Ank_2 29..122 CDD:289560 44/181 (24%)
ANK 2 58..87 17/28 (61%)
ANK 59..188 CDD:238125 49/183 (27%)
ANK repeat 59..89 CDD:293786 16/29 (55%)
ANK repeat 91..122 CDD:293786 13/85 (15%)
ANK 3 91..120 11/80 (14%)
Ank_2 96..199 CDD:289560 36/157 (23%)
ANK repeat 124..154 CDD:293786 10/29 (34%)
ANK 4 124..153 10/28 (36%)
ANK repeat 167..199 CDD:293786 13/31 (42%)
ANK 5 167..197 11/29 (38%)
Ank_2 172..270 CDD:289560 32/125 (26%)
ANK 196..321 CDD:238125 37/160 (23%)
ANK repeat 201..236 CDD:293786 9/34 (26%)
ANK 6 201..234 9/32 (28%)
2-5A binding (P-loop) 1 229..242 4/12 (33%)
ANK 7 238..268 9/57 (16%)
Ank_2 243..326 CDD:289560 26/118 (22%)
2-5A binding (P-loop) 2 253..275 3/21 (14%)
ANK repeat 272..326 CDD:293786 17/61 (28%)
ANK 8 272..301 11/36 (31%)
ANK 9 303..329 7/25 (28%)
PKc_like 375..587 CDD:304357 35/187 (19%)
Pkinase 387..586 CDD:278497 34/175 (19%)
RNase_RNase-L 590..708 CDD:199218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
tnks2NP_001017008.2 PTZ00322 28..>114 CDD:140343 24/86 (28%)
ANK repeat 61..89 CDD:293786 8/28 (29%)
PHA02876 <74..>438 CDD:165207 106/400 (27%)
ANK repeat 91..122 CDD:293786 17/30 (57%)
ANK repeat 124..155 CDD:293786 10/30 (33%)
ANK repeat 214..242 CDD:293786 10/37 (27%)
ANK repeat 244..275 CDD:293786 13/31 (42%)
ANK repeat 277..308 CDD:293786 9/33 (27%)
ANKYR 310..>472 CDD:223738 40/181 (22%)
ANK repeat 366..398 CDD:293786 12/37 (32%)
ANK repeat 400..431 CDD:293786 9/34 (26%)
ANK repeat 434..522 CDD:293786 16/95 (17%)
PHA03095 495..>804 CDD:222980 35/184 (19%)
ANK repeat 529..557 CDD:293786 8/39 (21%)
ANK repeat 559..590 CDD:293786 6/32 (19%)
ANK repeat 592..623 CDD:293786 2/30 (7%)
ANK repeat 645..675 CDD:293786
ANK repeat 682..710 CDD:293786
ANK repeat 712..743 CDD:293786
ANK repeat 745..776 CDD:293786
SAM_tankyrase1,2 872..937 CDD:188923
tankyrase_like 940..1161 CDD:238718
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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