DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and camk1

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001016269.1	Gene:	camk1 / 549023	XenbaseID:	XB-GENE-1017139	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	373	Identity:	82/373 - (21%)
Similarity:	142/373 - (38%)	Gaps:	112/373 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   331 PPAED---WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVK 392
            |..||   ||.::..    ::|::. :|.::|...|           ||  :.|...:|.:..|.
Frog     2 PLDEDGPSWKKRAED----IRDIYE-FREVLGTGAF-----------SE--VVLAEEKKTQKLVA 48

Human   393 TFC------EGSPRA-QREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRG 450
            ..|      ||...: :.|::.|:..: ::::|:.......|.||::.:.|          |..|
Frog    49 IKCIPKKALEGKETSIENEIAVLRKIK-HANIVSLEDIYESRSHLYLIMQL----------VSGG 102

Human   451 EDVE--------NEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL---IDSKKAAHLADF 504
            |..:        .|:|  |..::..|..||:.|| ..|..|:||:|:|:|   ||......::||
Frog   103 ELFDRIVEKGFYTEKD--ASQLIKQILDAVKYLH-DMGIVHRDLKPENLLYYSIDEDSKIMISDF 164

Human   505 DKS-IKWAGD--------------------PQEVKRDLEDLGRLVLYVVKKGSISFEDLK-AQSN 547
            ..| |:.:|.                    |.....|...:| ::.|::..|...|.|.. |:..
Frog   165 GLSKIEGSGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIG-VIAYILLCGYPPFYDENDAKLF 228

Human   548 EEVVQL-----SP-----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602
            |::::.     ||     .:..||.|..|.....:.|:.....|.||:.            .|:.
Frog   229 EQILKAEYEFDSPYWDDISDSAKDFIQHLMEKDPNKRNTCDQALQHPWI------------AGDT 281

Human   603 S-DIKTRKSESEILRLLQPGPSEHSKSFDK--WTTKIN-ECVMKKMNK 646
            : |....:|.||.:|          |:|.|  |....| ..|::.|.|
Frog   282 ALDKNIHESVSEQIR----------KNFAKSRWKQAFNATAVVRHMRK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560
		ANK 2	58..87
		ANK	59..188	CDD:238125
		ANK repeat	59..89	CDD:293786
		ANK repeat	91..122	CDD:293786
		ANK 3	91..120
		Ank_2	96..199	CDD:289560
		ANK repeat	124..154	CDD:293786
		ANK 4	124..153
		ANK repeat	167..199	CDD:293786
		ANK 5	167..197
		Ank_2	172..270	CDD:289560
		ANK	196..321	CDD:238125
		ANK repeat	201..236	CDD:293786
		ANK 6	201..234
		2-5A binding (P-loop) 1	229..242
		ANK 7	238..268
		Ank_2	243..326	CDD:289560
		2-5A binding (P-loop) 2	253..275
		ANK repeat	272..326	CDD:293786
		ANK 8	272..301
		ANK 9	303..329
		PKc_like	375..587	CDD:304357	59/261 (23%)
		Pkinase	387..586	CDD:278497	55/248 (22%)
		RNase_RNase-L	590..708	CDD:199218	14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
camk1	NP_001016269.1	STKc_CaMKI_alpha	17..279	CDD:271069	63/302 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910