DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and Ank

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	174/823 - (21%)
Similarity:	282/823 - (34%)	Gaps:	271/823 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV----------------- 75
            |.:.|.:|.| :..:.||..|||.:...|: |:|||..|:|...:.||
  Fly   143 LYMAAQENHD-NCCRTLLANGANPSLSTED-GFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPAL 205

Human    76 ------------ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTA 128
                        :|||:|..:..:..|:|.||..:||..|:|.:..|.|:..||||....:..|.
  Fly   206 HIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITP 270

Human   129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGA 193
            ...|..:||:.....|..|||.:          :...:.|.|.|..|:..|||||:|.||.:...
  Fly   271 LHVACKWGKLSLCTLLLCRGAKI----------DAATRDGLTPLHCASRSGHVEVIKHLLQQNAP 325

Human   194 DVNACDNMGRNAL-----------IHALLSS----DDSDVEAIT--------------HLLLDHG 229
            .:....| |.:||           .|.||.:    |:..|:.:|              .||||:.
  Fly   326 ILTKTKN-GLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYK 389

Human   230 ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294
            |:.|.|...|.|||.:|.:|..:.:|: ||.:....|..|...|.|.|.:|..:....|...|.:
  Fly   390 ANPNARALNGFTPLHIACKKNRIKMVE-LLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQ 453

Human   295 RGASTDC----GD--LVMTARRNY-------------------------------DHSLVKVLLS 322
            ..||.|.    |:  |.:.||.|.                               :.:::.:||.
  Fly   454 HEASADLPTIRGETPLHLAARANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQ 518

Human   323 HGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMI--GKLKFFIDEKYKIADTSEGGIYLGF-- 383
            |||  :.:..:.| |..:.|. ||.:....|.:.::  |.....:.:|             ||
  Fly   519 HGA--EINAQSND-KYSALHI-AAKEGQENIVQVLLENGAENNAVTKK-------------GFTP 566

Human   384 ------YEKQEVAVKTFCEGSP---RAQREVSCLQSSRENSHLVTFYGSES-------------- 425
                  |.||.|.......|:.   :.:.:|:.|       |:.|.|.:.|
  Fly   567 LHLACKYGKQNVVQILLQNGASIDFQGKNDVTPL-------HVATHYNNPSIVELLLKNGSSPNL 624

Human   426 --HRGHLFVCVTLCEQTLEACLD-VHRGEDVE-----------------NEE-----------DE 459
              ..|...:.:...:..||..:. :..|.||.                 |.:           ..
  Fly   625 CARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISA 689

Human   460 FARNVLSSIFKAVQE--------------------------LHLSCGYTHQDL------------ 486
            .|:|.|:.:..|.||                          ||::..|.|.||
  Fly   690 AAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIE 754

Human   487 QPQNI----LIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKK-GSIS-FEDLKAQ 545
            ...||    |..:.:..|:...:..::...:|..:.:|    |...|::... |.:: .|.||..
  Fly   755 MSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKD----GNTALHIASNLGYVTVMESLKIV 815

Human   546 SNEEVV--QLSPDEE-----TKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNES 603
            ::..|:  .:...||     |.:|:............| .|||.|       :.|:.:..    .
  Fly   816 TSTSVINSNIGAIEEKLKVMTPELMQETLLSDSDDESC-DDLLDH-------NHYKYMAT----D 868

Human   604 DIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNK 646
            |:|....:.:             |:||...|..:...:..:||
  Fly   869 DLKANYGQDQ-------------KNFDTTNTDHDLTDVSVLNK 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	9/27 (33%)
		ANK 1	24..53		9/24 (38%)
		Ank_2	29..122	CDD:289560	35/121 (29%)
		ANK 2	58..87		12/57 (21%)
		ANK	59..188	CDD:238125	44/157 (28%)
		ANK repeat	59..89	CDD:293786	12/58 (21%)
		ANK repeat	91..122	CDD:293786	13/30 (43%)
		ANK 3	91..120		12/28 (43%)
		Ank_2	96..199	CDD:289560	30/102 (29%)
		ANK repeat	124..154	CDD:293786	8/29 (28%)
		ANK 4	124..153		8/28 (29%)
		ANK repeat	167..199	CDD:293786	12/31 (39%)
		ANK 5	167..197		12/29 (41%)
		Ank_2	172..270	CDD:289560	37/126 (29%)
		ANK	196..321	CDD:238125	42/190 (22%)
		ANK repeat	201..236	CDD:293786	15/63 (24%)
		ANK 6	201..234		14/61 (23%)
		2-5A binding (P-loop) 1	229..242		4/12 (33%)
		ANK 7	238..268		10/29 (34%)
		Ank_2	243..326	CDD:289560	26/119 (22%)
		2-5A binding (P-loop) 2	253..275		6/21 (29%)
		ANK repeat	272..326	CDD:293786	18/90 (20%)
		ANK 8	272..301		8/28 (29%)
		ANK 9	303..329		9/58 (16%)
		PKc_like	375..587	CDD:304357	54/318 (17%)
		Pkinase	387..586	CDD:278497	50/297 (17%)
		RNase_RNase-L	590..708	CDD:199218	9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
Ank	NP_001162819.1	ANK	67..192	CDD:238125	18/50 (36%)
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560	9/24 (38%)
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786	9/26 (35%)
		ANK	204..320	CDD:238125	36/125 (29%)
		ANK repeat	204..231	CDD:293786	4/26 (15%)
		Ank_2	205..295	CDD:289560	26/99 (26%)
		ANK repeat	233..264	CDD:293786	13/30 (43%)
		ANK repeat	266..295	CDD:293786	8/38 (21%)
		ANK	294..419	CDD:238125	37/126 (29%)
		ANK repeat	299..330	CDD:293786	12/30 (40%)
		Ank_4	300..353	CDD:290365	17/53 (32%)
		ANK repeat	332..363	CDD:293786	8/31 (26%)
		Ank_2	337..428	CDD:289560	24/91 (26%)
		ANK	360..485	CDD:238125	35/125 (28%)
		ANK repeat	365..395	CDD:293786	7/29 (24%)
		ANK repeat	398..427	CDD:293786	10/29 (34%)
		ANK repeat	431..462	CDD:293786	9/30 (30%)
		Ank_2	436..526	CDD:289560	17/91 (19%)
		ANK repeat	464..494	CDD:293786	5/29 (17%)
		ANK	491..616	CDD:238125	26/148 (18%)
		ANK repeat	496..527	CDD:293786	5/32 (16%)
		Ank_2	501..592	CDD:289560	20/107 (19%)
		ANK repeat	529..560	CDD:293786	7/32 (22%)
		ANK	557..682	CDD:238125	21/144 (15%)
		ANK repeat	562..590	CDD:293786	8/40 (20%)
		Ank_5	582..636	CDD:290568	8/60 (13%)
		ANK repeat	595..625	CDD:293786	6/36 (17%)
		ANK repeat	628..657	CDD:293786	6/28 (21%)
		Ank_2	633..723	CDD:289560	12/89 (13%)
		ANK repeat	661..691	CDD:293786	1/29 (3%)
		ANK	692..812	CDD:238125	21/123 (17%)
		ANK repeat	693..724	CDD:293786	5/30 (17%)
		Ank_2	698..788	CDD:289560	14/89 (16%)
		ANK repeat	726..755	CDD:293786	6/28 (21%)
		ANK repeat	759..788	CDD:293786	4/28 (14%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900